产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IRAK1多克隆抗体
目录 :
PA5-19855
规格 :
100微克
价格 :
美国446.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
文章摘录数: 2
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产品信息
产品类型 :
抗体
产品名称 :
IRAK1多克隆抗体
目录# :
PA5-19855
规格 :
100微克
价格 :
美国446.00
克隆性 :
多克隆
纯度 :
Anitgen affinity chromatography
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunocytochemistry: 10 µg/mL, Immunoprecipitation: 2-4 µg, Western Blot: 1 µg/mL
物种 :
人类, 小鼠, 大鼠
抗体亚型 :
IgG
储存 :
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
描述 :
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK's association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus. This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state.
免疫原 :
A peptide corresponding to amino acids near the carboxy terminus of human IRAK.
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 10 µg/mL, Immunoprecipitation: 2-4 µg, Western Blot: 1 µg/mL
别名 :
AA408924; Il1rak; interleukin 1 receptor associated kinase 1; interleukin-1 receptor-associated kinase 1; interleukin-1 receptor-associated kinase-1; IRAK; Irak1; IRAK-1; IRAK1-S; mPLK; pelle; Pelle homolog; pelle-like protein kinase; Plpk; RGD1563841
更多信息或购买 :
公司信息
赛默飞世尔