NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

抗体

ATG5 Polyclonal Antibody, DyLight™ 650

PA5-22855

100微升

美国449.00

多克隆

domestic rabbit

DyLight系列染料650

豚鼠, 人类, 小鼠, 大鼠, 牛, pigs , 斑马鱼, fruit fly , 非洲爪蛙

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片

ATG5 Polyclonal Antibody, DyLight™ 650

PA5-22855

100微升

美国449.00

多克隆

抗原亲和色谱

兔

Bovine, Drosophila, Fish, Guinea Pig, Human, Mouse, Non-human primate, Porcine, Rat, Reptile, Xenopus laevis, Zebrafish

ELISA: Assay-Dependent, Flow Cytometry: Assay-Dependent, Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: 1:500

Bovine, Drosophila, Fish, Guinea Pig, Human, Mouse, Non-human primate, Porcine, Rat, Reptile, Xenopus laevis, Zebrafish

IgG

4° C, store in dark

ATG5 (Autophagy Related 5) is an important element for autophagy and may play an important role in the apoptotic process. ATG5 is also involved in other cellular processes that include mitochondrial quality control after oxidative damage, negative regulation of the innate anti-viral immune response, lymphocyte development and proliferation, MHC II antigen presentation, and adipocyte differentiation. Following conjugation to ATG12, the conjugate participates in the formation of autophagosome. ATG5 contributes to autophagic cell death by interacting with Fas-associated protein with death domain (FADD). The ATG5-ATG12 conjugate forms a cup-shaped isolation membrane that then detaches from the membrane immediately before or after autophagosome formation is completed. APG5 may play a role in the apoptotic process, possibly within the modified cytoskeleton. Further, APG5 expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. The APG5-APG12 conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. Diseases associated with ATG5 dysfunction include spinocerebellar ataxia.

A synthetic peptide made to an N-terminal region (within residues 1-50) of the human ATG5 protein.

液体

ELISA: Assay-Dependent, Flow Cytometry: Assay-Dependent, Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: 1:500

2010107M05Rik; 3110067M24Rik; APG 5; APG5; APG5 autophagy 5 like (APG5L); APG5 autophagy 5-like protein; APG5 autophagy 5-like protein, isoform 1; APG5L; APG5-LIKE; apoptosis-specific protein; Apoptosis-specific protein (ASP); ASP; atg5; Atg-5; ATG5 autophagy related 5 homolog; ATG5 autophagy related 5 homolog (S. cerevisiae); atg5.L; Atg5l; Atg5-PA; autophagy 5-like protein; autophagy protein 5; autophagy related 5; autophagy related 5 L homeolog; autophagy related 5-like protein; Autophagy-related 5; autophagy-specific gene 5; AW319544; C88337; CG1643; CG1643-PA; DmAtg5; Dmel CG1643; Dmel_CG1643; hAPG5; hypothetical protein LOC532686; LD34980p; Paddy; XELAEV_18027227mg; zgc:100934