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抗体

KV1.2(KCNA2)多克隆抗体

PA5-23011

100微升

美国402.00

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠, 犬, 牛, pigs , 非洲爪蛙, domestic rabbit

免疫印迹, 中和反应, 免疫沉淀

KV1.2(KCNA2)多克隆抗体

PA5-23011

100微升

美国402.00

多克隆

兔

牛, 狗, 人类, 小鼠, 猪, 兔, 大鼠, 非洲爪蛙

Immunoprecipitation: 1:10-1:500, Neutralization: 50-200 molar excess, Western Blot: 1:500-1:1,000

牛, 狗, 人类, 小鼠, 猪, 兔, 大鼠, 非洲爪蛙

IgG

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

Kcna2 is a voltage-gated potassium channel (KV) that belongs to the 6-TM family of potassium channel and also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. The diverse functions of potassium channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). The Kcna2 gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. Kcna2 contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. Further, Kcna2 belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of the Kcna2 gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. Diseases associated with KCNA2 include Epileptic Encephalopathy (Early Infantile, 32) and Undetermined Early-Onset Epileptic Encephalopathy.

Synthetic peptide made to a portion of rat Kv1.2 (within residues 325-375).

液体

Immunoprecipitation: 1:10-1:500, Neutralization: 50-200 molar excess, Western Blot: 1:500-1:1,000

Akr6a4; BK2; CSMK1; delayed rectifier K+ channel; EIEE32; ENSMUSG00000074335; Gm10672; HBK5; HK4; HUKIV; k(v)1.2; KC22; Kca1-2; kcna2; kcna2.S; kcna2-a; KV1.2; Kv1.2' potassium channel; LOC100537815; MK2; Mk-2; NGK1; Potassium (K+) channel protein alpha 2, voltage dependent; potassium channel (BGK5); potassium channel subunit Kv 1.2; potassium channel, voltage gated shaker related subfamily A, member 2; potassium channel, voltage gated shaker related subfamily A, member 2 S homeolog; potassium voltage gated channel shaker related subfamily member 2; potassium voltage-gated channel subfamily A member 2; potassium voltage-gated channel, shaker-related subfamily, member 2; potassium voltage-gated channel, shaker-related subfamily, member 2 a; RAK; RBK2; RCK5; RP11-284N8.1; voltage-dependent K channel; voltage-gated channel, shaker-related subfamily, member 2; voltage-gated K(+) channel HuKIV; Voltage-gated potassium channel HBK5; voltage-gated potassium channel isoform 2; voltage-gated potassium channel isoform 3; voltage-gated potassium channel protein Kv1.2; Voltage-gated potassium channel subunit Kv1.2; XELAEV_18011981mg; XSha2