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抗体

Toll样受体4多克隆抗体

PA5-23124

100微克

美国450.00

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠, 猕猴

免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片

Toll样受体4多克隆抗体

PA5-23124

100微克

美国450.00

多克隆

抗原亲和色谱

兔

人类, 小鼠, 大鼠, 猕猴

Flow Cytometry: 20 µg x 10^6 cells, Immunocytochemistry: 2-5 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL, Western Blot: 2-5 µg/mL

人类, 小鼠, 大鼠, 猕猴

IgG

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

TLR4 is member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. Mutations in the TLR4 gene have been associated with differences in LPS responsiveness. Also, several transcript variants of the TLR4 gene have been found, but the protein coding potential of most of them is uncertain. TLR4 is expressed by peripheral blood monocytes and a small population of B-cells and is also expressed in human placenta. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.

This TLR4 antibody was developed against a synthetic peptide corresponding to amino acids in a range between 30-80 of mouse TLR4.

液体

Flow Cytometry: 20 µg x 10^6 cells, Immunocytochemistry: 2-5 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL, Western Blot: 2-5 µg/mL

ARMD10; CD284; EGK_07381; homolog of Drosophila toll; hToll; lipopolysaccharide response; Lps; Ly87; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; toll like receptor 4; toll/interleukin-l receptor (TIR) domain; toll4; toll-like receptor 4; toll-like receptor 4 immunity-related protein; Toll-like receptor 4-like protein; Toll-like receptor4 protein