NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

抗体

SOX1多克隆抗体

PA5-23351

100微克

美国456.00

多克隆

domestic rabbit

未共轭

热带爪蟾, 人类, 小鼠, 非洲爪蛙

SOX1多克隆抗体

PA5-23351

100微克

美国456.00

多克隆

抗原亲和色谱

兔

Equine, Human, Marsupial, Mouse, Non-human primate, Xenopus laevis

Western Blot: 1-4 µg/mL

Equine, Human, Marsupial, Mouse, Non-human primate, Xenopus laevis

IgG

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

SOX1, also known as SRY (sex determining region Y)-box 1, is a transcription factor belonging to the SRY-related HMG box family of transcription factors with a HMG box DNA-binding domain. SOX1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation. This nuclear protein acts as a modulator of LINE retroposons promoter activity and is also involved in the development of the central nervous system, mainly neural and lens development. Transcriptional activator SOX1 binds directly to the HES1 promoter and suppresses HES1 transcription, thus attenuating Notch signaling. It also binds to beta-catenin and suppresses beta-catenin-mediated TCF/LEF signaling, thus potentially attenuating the WNT signaling pathway. Expression of SOX1 is seen mostly in embryonic tissues and moderately in brain.

A portion of amino acids 100-150 of human SOX1

液体

Western Blot: 1-4 µg/mL

BB176347; LOC100912302; sex determining region Y-box 1; Sox1; Sox-1; sox1.S; SRY (sex determining region Y)-box 1; SRY box 1; SRY-box 1; SRY-box 1 S homeolog; SRY-box containing gene 1; SRY-box containing protein; SRY-box transcription factor 1; SRY-related HMG-box gene 1; transcription factor SOX-1; transcription factor SOX-1-like; XELAEV_18015596mg; XlSox1; xSox1