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抗体

MMP19多克隆抗体

PA5-32502

500微升

美国351.00

多克隆

domestic rabbit

未共轭

免疫组化, 免疫组化-石蜡切片

MMP19多克隆抗体

PA5-32502

500微升

美国351.00

多克隆

抗原亲和色谱

兔

人类

免疫组化(石蜡): 1:25

人类

IgG

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

MMP-19 (RASI-1, MMP-18) is a 508 amino acid peptide, originally isolated as an autoantigen from the synovium of a patient suffering from rheumatoid arthritis (RA). Its presence on the surface of activated PBMCs, TH1 lymphocytes, and Jurkat T lymphoma cells in the synovium of acute RA patients, suggests that MMP-19 plays a role in RA-associated joint tissue destruction. MMP-19 exists in the smooth muscle cells of the tunica media of large blood vessels of the RA patient, but not in the endothelial cell layer. Acutely inflamed tissue synovial capillaries strongly express MMP-19 in the cytoplasm. Regulated induction of MMP-19 in capillary endothelial cells during acute inflammation suggest a role in angiogenesis. MMP-19 is a single 2.7kb transcript found in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis, colon, and heart.

合成肽来自N末端人的基质金属蛋白酶-19蛋白

液体

免疫组化(石蜡): 1:25

CODA; matrix metallo protease; matrix metallopeptidase 19; matrix metalloproteinase 19; matrix metalloproteinase RASI; Matrix metalloproteinase-18; matrix metalloproteinase-19; matrix metalloproteinase-beta19; MMP; MMP18; MMP-18; Mmp19; MMP-19; MMPs; Rasi; RASI-1