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抗体

黄蜂多克隆抗体

PA5-37303

100微升

美国496.00

多克隆

domestic rabbit

未共轭

免疫印迹, 免疫细胞化学

黄蜂多克隆抗体

PA5-37303

100微升

美国496.00

多克隆

抗原亲和色谱

兔

人类

Immunocytochemistry: 1:50-1:200, Western Blot: 1:500-1:2,000

人类

IgG

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

The Wiskott-Aldrich syndrome family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.

重组全长人类黄蜂

液体

Immunocytochemistry: 1:50-1:200, Western Blot: 1:500-1:2,000

2900021I12Rik; 3110031I02Rik; eczema-thrombocytopenia; IMD2; neural Wiskott-Aldrich syndrome protein; NWASP; N-WASP; SCNX; THC; THC1; thrombocytopenia 1 (X-linked); TRS4; U42471; Was; WASL; Wasp; WASPA; WASPB; Wiskott-Aldrich syndrome; Wiskott-Aldrich syndrome homolog; Wiskott-Aldrich syndrome homolog (human); Wiskott-Aldrich syndrome like; wiskott-Aldrich syndrome protein; Wiskott-Aldrich syndrome protein homolog; Wiskott-Aldrich syndrome-like; Wiskott-Aldrich syndrome-like (human)