产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
磷酸化LATS1/LATS2(Thr1079, Thr1041)多克隆抗体
目录 :
PA5-37834
规格 :
100微升
价格 :
美国436.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫组化, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
产品类型 :
抗体
产品名称 :
磷酸化LATS1/LATS2(Thr1079, Thr1041)多克隆抗体
目录# :
PA5-37834
规格 :
100微升
价格 :
美国436.00
克隆性 :
多克隆
纯度 :
亲和色谱
宿主 :
兔
反应物种 :
人类, 小鼠
应用 :
免疫组化(石蜡): 1:50-1:100
物种 :
人类, 小鼠
抗体亚型 :
IgG
储存 :
-20°C
描述 :
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
免疫原 :
Peptide sequence around phosphorylation site of threonine 1079/1041 (E-F-T(p)-F-R) derived from Human LATS1/2.
格式 :
液体
应用w/稀释 :
免疫组化(石蜡): 1:50-1:100
别名 :
4932411G09Rik; AV277261; AW208599; AW228608; h-warts; kinase phosphorylated during mitosis protein; KPM; large tumor suppressor; large tumor suppressor 2; large tumor suppressor homolog 1; Large tumor suppressor homolog 2; large tumor suppressor kinase 1; large tumor suppressor kinase 2; large tumor suppressor, homolog 2; large tumor supressor, homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS (large tumor suppressor, Drosophila) homolog 2; LATS, large tumor suppressor, homolog 1; LATS, large tumor suppressor, homolog 2; lats1; Lats2; RGD1564085; serine/threonine kinase KPM; serine/threonine-protein kinase kpm; Serine/threonine-protein kinase LATS1; serine/threonine-protein kinase LATS2; WARTS; WARTS protein kinase; warts-like kinase; wts
更多信息或购买 :
公司信息
赛默飞世尔