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抗体

磷酸化肿瘤坏死因子受体超家族成员6(Tyr291)多克隆抗体

PA5-38490

100微克

美国446

多克隆

domestic rabbit

未共轭

磷酸化肿瘤坏死因子受体超家族成员6(Tyr291)多克隆抗体

PA5-38490

100微克

美国446

多克隆

抗原亲和色谱

兔

Human, Non-human primate

Immunocytochemistry: 1:100-1:500, Immunofluorescence: 1:100-1:500, peptide-ELISA: 1:1000

Human, Non-human primate

IgG

-20°C

FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor of the TNFR (tumor necrosis factor receptor) superfamily. FAS also exists in a soluble form that weight approximately 26kDa. Stimulation of FAS results in aggregation of its intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC) and activation of caspases. The auto-proteolytic processing of the caspases in the complex trigger a downstream cascade that leads to apoptosis. FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full-length isoform. The Fas/Fas ligand system has been shown to play a role in a number of human diseases such as AIDS, hepatitis and cancer. It is also assumed that induction of apoptosis through FAS ligand pathway is predominantly involved in anti-viral immune responses.

A synthetic phosphopeptide derived from human FAS around the phosphorylation site of Tyr291 (E-A-YP-D-T)

液体

Immunocytochemistry: 1:100-1:500, Immunofluorescence: 1:100-1:500, peptide-ELISA: 1:1000

AI196731; ALPS1A; APO1; APO-1; Apo1 antigen; apo-1 antigen; APO-1 cell surface antigen; Apo-1 Fas; apoptosis antigen 1; apoptosis signaling receptor FAS; apoptosis-mediating surface antigen FAS; APT1; CD95; CD95 antigen; fas; Fas (TNF receptor superfamily member 6); Fas (TNF receptor superfamily member); Fas (TNF receptor superfamily, member 6); Fas AMA; Fas antigen; Fas antigen (ATP1); Fas cell surface death receptor; Fas receptor; FAS1; FASLG receptor; FASTM; lpr; lymphoproliferation; OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000059646; TNF receptor superfamily member 6; TNFR6; Tnfrsf6; Tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6