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抗体

AKT1/AKT3多克隆抗体

PA5-39727

100微克

美国402.00

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

AKT1/AKT3多克隆抗体

PA5-39727

100微克

美国402.00

多克隆

抗原亲和色谱

兔

人类, 小鼠, 大鼠

Western Blot: 1:500-1:1,000

人类, 小鼠, 大鼠

IgG

-20°C

AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling.

A synthetic non-phosphopeptide derived from human AKT1/3 around the phosphorylation site of Tyr437/434 (T-R-YP-F-D)

液体

Western Blot: 1:500-1:1,000

AI851531; Akt; AKT serine/threonine kinase 1; AKT serine/threonine kinase 3; AKT1; AKT1 kinase; AKT1m; Akt1m protein; AKT3; AKT3 kinase; C-AKT; CWS6; D930002M15Rik; EC 2.7.11.1; MPPH; MPPH2; murine thymoma viral (v-akt) oncogene homolog 1; Nmf350; PKB; PKB alpha; PKB gamma; PKB/Akt; PKBalpha; PKB-ALPHA; PKBG; PKB-GAMMA; PRKBA; PRKBG; Protein kinase Akt-3; Protein kinase B; Protein kinase B alpha; protein kinase B gamma; protein kinase B, gamma; protein kinase B-alpha; proto-oncogene c-AKT; RAC; rac protein kinase alpha; RAC protein kinase alpha RAC-PK alpha; RAC-ALPHA; RAC-alpha serine/threonine-protein kinase; RAC-gamma; RAC-gamma serine/threonine protein kinase; RAC-gamma serine/threonine-protein kinase; RAC-PK-alpha; RAC-PK-gamma; related to A and C kinases; serine-threonine protein kinase; STK-2; Thymoma viral proto-oncogene; thymoma viral proto-oncogene 1; thymoma viral proto-oncogene 3; v-akt murine thymoma viral oncogene 3; v-akt murine thymoma viral oncogene homolog 1; v-akt murine thymoma viral oncogene homolog 3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); v-akt murine thymoma viral oncogene-like protein 1