产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
磷酸化MER/SKY(Tyr749, Tyr681)多克隆抗体
目录 :
PA5-40270
规格 :
100微升
价格 :
美国440.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化
更多信息或购买 :
文章摘录数: 1
产品信息
产品类型 :
抗体
产品名称 :
磷酸化MER/SKY(Tyr749, Tyr681)多克隆抗体
目录# :
PA5-40270
规格 :
100微升
价格 :
美国440.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
应用 :
ELISA: 1:10,000, Immunohistochemistry: 1:100-1:300, Western Blot: 1:500-1:2,000
物种 :
人类, 小鼠, 大鼠
抗体亚型 :
IgG
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
免疫原 :
Synthesized peptide derived from human MerTK/Tyro3 around the phosphorylation site of Y749/681.
格式 :
液体
应用w/稀释 :
ELISA: 1:10,000, Immunohistochemistry: 1:100-1:300, Western Blot: 1:500-1:2,000
别名 :
AI323366; Brt; Bruton agammaglobulinemia tyrosine kinase; BYK; c-Eyk; c-mer; c-mer proto-oncogene tyrosine kinase; Dtk; EC 2.7.10.2; Etk-2; etk2/tyro3; Eyk; kinase Syk; KSYK; Mer; MER proto-oncogene, tyrosine kinase; MER receptor tyrosine kinase; MERTK; nmf12; Nyk; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; rdy; Receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; Rek; retinal dystrophy; RP38; RSE; Sky; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; SYK; Tif; TK19-2; Tyro 12; Tyro12; Tyro3; TYRO3 protein tyrosine kinase; TYRO3 protein tyrosine kinase 3; tyrosine-protein kinase byk; Tyrosine-protein kinase DTK; tyrosine-protein kinase Mer; Tyrosine-protein kinase receptor TYRO3; tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; tyrosine-protein kinase TIF
更多信息或购买 :
公司信息
赛默飞世尔