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抗体

磷酸化KChIP3(Ser63)多克隆抗体

PA5-40289

100微升

美国446.00

多克隆

domestic rabbit

未共轭

人类, 小鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学

磷酸化KChIP3(Ser63)多克隆抗体

PA5-40289

100微升

美国446.00

多克隆

抗原亲和色谱

兔

人类, 小鼠

ELISA: 1:20,000, Immunocytochemistry: 1:200-1:1,000, Immunohistochemistry: 1:100-1:300, Western Blot: 1:500-1:2,000

人类, 小鼠

IgG

-20° C, 避免反复冷冻/解冻

Voltage-gated potassium (Kv) channels are key components of the potassium currents in the heart and central nervous system. In the heart, Kv4 channels are involved in the repolarization phase of the action potential. In the brain however, these channels prevent reverse-propagation of action potentials. Found associated with Kv4 channels are a group of calcium-binding proteins termed KChIPs (Kv channel interacting proteins). KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and help to modulate its function. There are currently three known KChIPs; KChIP1 expressed in the brain; KChIP2 expressed in the brain, heart, and lung, and has three isoforms, a, b, and c; and KChIP3, also known as calsenilin and DREAM (downstream regulatory elements (DRE)-antagonist modulator) which is expressed in the brain and testis. KChIP3 has activities beyond the modulation of Kv4 currents. It has been shown that KChIP3 binds to the regulatory DRE and represses transcription from the early-response gene c-fos. Thus, KCHiP3 is the first known calcium-binding protein to function as a DNA-binding transcriptional regulator. KChIP3 is also found associated with the presenilins and is implicated in the mediation of beta-amyloid formation.

Synthesized peptide derived from human DREAM around the phosphorylation site of S63.

液体

ELISA: 1:20,000, Immunocytochemistry: 1:200-1:1,000, Immunohistochemistry: 1:100-1:300, Western Blot: 1:500-1:2,000

4933407H12Rik; AI413860; A-type potassium channel modulating protein 3; A-type potassium channel modulatory protein 3; Calsenilin; calsenilin presenilin-binding protein EF hand transcription factor; calsenilin, presenilin binding protein, EF hand transcription factor; calsenilin, presenilin-binding protein, EF hand transcription fa; calsenilin, presenilin-binding protein, EF hand transcription factor; CSEN; downstream regulatory element-antagonist modulator; DREAM; DRE-antagonist modulator; KChIP3; KCNIP3; Kv channel interacting protein 3; Kv channel interacting protein 3, calsenilin; kv channel-interacting protein 3; potassium channel interacting protein 3; potassium voltage-gated channel interacting protein 3; R74849; rKChIP3