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抗体

SPHK2多克隆抗体

PA5-51064

100微升

美国446.00

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化

SPHK2多克隆抗体

PA5-51064

100微升

美国446.00

多克隆

抗原亲和色谱

兔

人类, 小鼠, 大鼠

ELISA: 1:5,000, Immunohistochemistry: 1:100-1:300, Western Blot: 1:500-1:2,000

人类, 小鼠, 大鼠

IgG

-20° C, 避免反复冷冻/解冻

SPHK2, along with SPHK1, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P). S1P signals through G-protein coupled receptors and controls diverse cellular processes. Inhibitors of SPHKs are viewed as potential therapeutics for the treatment of cancer. SPHK2 is an important signaling molecule with intra- and extracellular functions and has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors). These receptors couple to multiple G proteins (e.g. S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a extremely wide raange of cellular events including cell motility, survival, apoptosis, migration and cell-cell interaction. Important roles for S1P have also been reported in regulation of cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, cells of the neuronal system and bone cells. S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).

Synthesized peptide derived from human SphK2 around the non-phosphorylation site of T614.

液体

ELISA: 1:5,000, Immunohistochemistry: 1:100-1:300, Western Blot: 1:500-1:2,000

C76851;SK 2;SK2;SK-2;鞘氨醇激酶2;鞘氨醇激酶类型2;Sphk2;SPK 2;SPK-2;Spk2, Sk2