NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

抗体

UPF3B多克隆抗体

PA5-51638

100微升

美国456.00

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化

UPF3B多克隆抗体

PA5-51638

100微升

美国456.00

多克隆

抗原亲和色谱

兔

人类, 小鼠, 大鼠

Immunohistochemistry: 1:200-1:500, Western Blot: 0.04-0.4 µg/mL

人类, 小鼠, 大鼠

IgG

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The protein is one of two functional homologs to yeast Upf3p. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.

Recombinant protein corresponding to Human UPF3B

液体

Immunohistochemistry: 1:200-1:500, Western Blot: 0.04-0.4 µg/mL

5730594O13Rik; AI317193; AW541158; HUPF3B; hUpf3p-X; mental retardation, X-linked 62; MRX62; MRXS14; Nonsense mRNA reducing factor 3B; regulator of nonsense transcripts 3B; RENT3B; RGD1560264; Unknown (protein for MGC:134301); UPF3 regulator of nonsense transcripts homolog B; UPF3 regulator of nonsense transcripts homolog B (yeast); UPF3 regulator of nonsense transcripts-like protein B; UPF3B; UPF3B pseudogene 1; UPF3B pseudogene 2; UPF3B pseudogene 3; UPF3B regulator of nonsense mediated mRNA decay; UPF3BP1; UPF3BP2; UPF3BP3; Upf3p-X; UPF3X; up-frameshift suppressor 3 homolog B; Up-frameshift suppressor 3 homolog on chromosome X