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抗体

Septin 2 Polyclonal Antibody

PA5-53814

100微升

美国496.00

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学

Septin 2 Polyclonal Antibody

PA5-53814

100微升

美国496.00

多克隆

抗原亲和色谱

兔

人类, 小鼠, 大鼠

Immunocytochemistry: 0.25-2 µg/mL, Immunohistochemistry: 1:200-1:500, Western Blot: 0.04-0.4 µg/mL

人类, 小鼠, 大鼠

IgG

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

Septin 2 is a filament-forming cytoskeletal GTPase. Septin 2 is required for normal organization of the actin cytoskeleton and plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. It is required for the progression through mitosis, and it forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, Septin 2 may be required for chromosome segregation and spindle elongation. Septin 2 also plays a role in ciliogenesis and collective cell movements.

Recombinant protein corresponding to Human Septin 2

液体

Immunocytochemistry: 0.25-2 µg/mL, Immunohistochemistry: 1:200-1:500, Western Blot: 0.04-0.4 µg/mL

2-Sep; AW208991; DIFF6; hNedd5; KIAA0158; mKIAA0158; NEDD5; Nedd-5; Neural precursor cell expressed developmentally down-regulated protein 5; neural precursor cell expressed, developmentally down-regulated 5; neural precursor cell expressed, developmentally down-regulated gene 5; Pnutl3; Sept2; septin 2; Septin2; septin-2; Vascular endothelial cell specific protein 11; Vesp11