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抗体

RBL1多克隆抗体

PA5-79916

100微克

美国385.00

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫组化-石蜡切片

RBL1多克隆抗体

PA5-79916

100微克

美国385.00

多克隆

抗原亲和色谱

兔

人类, 小鼠, 大鼠

Immunohistochemistry (Paraffin): 0.5-1 µg/mL, Western Blot: 0.1-0.5 µg/mL

人类, 小鼠, 大鼠

IgG

-20°C

RB-like 1 is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and RB-like 1 can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that RB-like 1 may also be a tumor suppressor.

A synthetic peptide corresponding to a sequence at the C-terminus of human p107 (1048-1068aa QENDDVLLKRLQDVVSERANH).

冻干

Immunohistochemistry (Paraffin): 0.5-1 µg/mL, Western Blot: 0.1-0.5 µg/mL

107 kDa retinoblastoma-associated protein; AW547426; CP107; DNA-binding protein RFX5; MGC40006; p107; pRb1; RB transcriptional corepressor like 1; Rbl1; Regulatory factor X 5; regulatory factor X, 5 (influences HLA class II expression); regulatory factor X5; retinoblastoma-like 1; retinoblastoma-like 1 (p107); retinoblastoma-like protein 1; RFX5