产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
PAX2多克隆抗体
目录 :
PA5-81235
规格 :
100微升
价格 :
美国299
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 1
参考文献
Gupta S, Yamauchi K, Novitch B, Butler S. Derivation of dorsal spinal sensory interneurons from human pluripotent stem cells. STAR Protoc. 2021;2:100319 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
PAX2多克隆抗体
目录# :
PA5-81235
规格 :
100微升
价格 :
美国299
克隆性 :
多克隆
纯度 :
抗原亲和色谱, 蛋白质A
宿主 :
反应物种 :
人类
应用 :
Immunocytochemistry: 1:300-1:10000, Immunofluorescence: 1:300-1:10000, Immunohistochemistry (Paraffin): 1:2500-1:10000, Western Blot: 1:500-1:2000
物种 :
人类
抗体亚型 :
IgG
储存 :
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
描述 :
The pax genes are a family of transcription factors that are active in specific tissues during early embryonic development. Pax family members possess a DNA-binding domain encoded by the paired box. Because paired domain containing genes encode transcription factors, they are capable of executing a genetic program. Several pax genes have also been associated with developmental mutations including: pax-3, which is associated with Waardenburg syndrome, pax-6, which is associated with Aniridia, and pax-2, which is associated with Wilms tumor. During embryogenesis, Pax-2 is expressed in the developing kidney. In particular, the pax-2 gene is expressed in condensing metanephric mesenchyme and in early epithelial structures derived from mesenchyme; however, pax-2 mRNA and protein levels are rapidly down regulated as the tubular epithelium matures. Although Pax-2 is down regulated during renal epithelium maturation, Pax-2 expression persists in the undifferentiated epithelium of Wilms' tumors. Persistent expression of Pax-2 in Wilms' tumors occurs frequently and correlates with the proliferation of poorly differentiated epithelial cells in these tumors. Interestingly, expression of the Wilms' tumor suppresser protein, WT1, coincides with down-regulation of the pax-2 gene; thus, suggesting that WT1 can directly repress pax-2 transcription.
免疫原 :
A合成多肽对应于C末端人的PAX2
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:300-1:10000, Immunofluorescence: 1:300-1:10000, Immunohistochemistry (Paraffin): 1:2500-1:10000, Western Blot: 1:500-1:2000
别名 :
FSGS7; Opdc; optic disc coloboma; paired box 2; paired box gene 2; paired box homeotic gene 2; paired box protein Pax-2; PAPRS; Pax2; Pax-2
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国