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抗体

周期蛋白E多克隆抗体

PA5-85177

100微升

美国436.00

多克隆

domestic rabbit

未共轭

免疫印迹, 免疫细胞化学

周期蛋白E多克隆抗体

PA5-85177

100微升

美国436.00

多克隆

抗原亲和色谱

兔

人类

Immunocytochemistry: 1:100-1:1,000, Western Blot: 1:500-1:3,000

人类

IgG

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

Cyclin E belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.

Recombinant protein encompassing a sequence within the C-terminus region of human Cyclin E1.

液体

Immunocytochemistry: 1:100-1:1,000, Western Blot: 1:500-1:3,000

AW538188; Ccne; Ccne1; CycE1; CYCLE; cyclin E; cyclin E1; cyclin Es; cyclin Et; E-S; G1/S-specific cyclin-E1; pCCNE1