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抗体

DLL4 (delta-like 4) Polyclonal Antibody

PA5-85931

100微升

美国436.00

多克隆

domestic rabbit

未共轭

人类, 小鼠

免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪

DLL4 (delta-like 4) Polyclonal Antibody

PA5-85931

100微升

美国436.00

多克隆

蛋白质A

兔

人类, 小鼠

Flow Cytometry: 1:50-1:100, Immunocytochemistry: 1:50-1:200, Immunohistochemistry: 1:50-1:200, Western Blot: 1:500-1:1,000

人类, 小鼠

IgG

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.

Recombinant protein within Human DLL4 aa 175-370

液体

Flow Cytometry: 1:50-1:100, Immunocytochemistry: 1:50-1:200, Immunohistochemistry: 1:50-1:200, Western Blot: 1:500-1:1,000

AOS6; delta 4; delta ligand 4; delta like canonical Notch ligand 4; Delta4; delta-like 4 (Drosophila); delta-like 4 homolog; delta-like 4 protein; delta-like protein 4; DLL4; Drosophila Delta homolog 4; hdelta2; MGC126344; notch ligand delta-2; notch ligand DLL4; UNQ1895/PRO4341