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抗体

UBE2V2多克隆抗体

PA5-98227

100微克

美国446.00

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫组化-石蜡切片

UBE2V2多克隆抗体

PA5-98227

100微克

美国446.00

多克隆

蛋白质G

兔

人类, 小鼠, 大鼠

ELISA: Assay-Dependent, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1:500-1:5,000

人类, 小鼠, 大鼠

IgG

-20°C or -80°C if preferred

The differentiation and activation of monocytes (MO) and monocytic cells is modulated by 1alpha,25-dihydroxyvitamin D3 (Vitamin D3). Recently, using mRNA Differential Display technology, Fritsche J, et al have identified a gene which is induced in freshly isolated human blood MO that are cultured for 4 hours with Vitamin D3. This cDNA encodes a putative 16.5 kD protein. The product of this gene has structural homology with yeast MMS2p and human CROC-1), which defines a structurally and functionally conserved Ubc-like protein family. This protein was called Ubiquitin E2 variant (UBE2V2) or MMS2 (methyl methanesulfonate sensitive 2). The yeast UEV protein, Mms2, is required together with Ubc13 for RAD6/RAD18-dependent postreplicative DNA repair in yeast. These proteins also play a central role in the assembly of K63-linked polyubiquitin chains (4,5) UEV/Ubc complexes have been implicated in the assembly of Lys63-linked polyubiquitin chains that act as a novel signal in postreplicative DNA repair and IkBa kinase activation. Recent crystal structure analysis provides direct evidence that the Mms2/Ubc13 heterodimer is necessary for DNA repair.

Recombinant Human Ubiquitin-conjugating enzyme E2 variant 2 protein (2-145AA)

液体

ELISA: Assay-Dependent, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1:500-1:5,000

1 alpha,25-dihydroxyvitamin D3-inducible; 1110021H13Rik; 4632410D19Rik; 5730524P06Rik; 6820402M05; AI848315; C81524; DDVit 1; DDVIT1; DDVit-1; EDAF-1; EDPF1; EDPF-1; enterocyte differentiation promoting factor; enterocyte differentiation-associated factor 1; enterocyte differentiation-associated factor EDAF-1; enterocyte differentiation-promoting factor 1; meth; methyl methanesulfonate sensitive 2; methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of; Mms2; MMS2 homolog; ubc-like protein MMS2; UBE2V2; ubiquitin conjugating enzyme E2 V2; ubiquitin conjugating enzyme E2 variant 2; ubiquitin-conjugating enzyme E2 variant 2; ubiquitin-conjugating enzyme E2v2; ubiquitin-conjugating enzyme variant MMS2; UEV2; UEV-2; vitamin D3-inducible protein