产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CYP11B2多克隆抗体
目录 :
PA5-99805
规格 :
100微升
价格 :
美国456.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
产品类型 :
抗体
产品名称 :
CYP11B2多克隆抗体
目录# :
PA5-99805
规格 :
100微升
价格 :
美国456.00
克隆性 :
多克隆
纯度 :
亲和色谱
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunohistochemistry (Paraffin): 1:200, Western Blot: 1:1,000-1:3,000
物种 :
人类, 小鼠, 大鼠
抗体亚型 :
IgG
储存 :
-20°C
描述 :
The steroid 11beta-hydroxylase gene, also designated Cyp11b-1, is a marker for the functional differentiation of cells in the zonae fasciculata reticularis. The deduced protein CYP11B1 consists of 466 amino acids containing a secretory signal, epidermal growth factor-like repeats, and a proteolytically inactive cathepsin B-related sequence. A related protein, human aldosterone synthase (CYP11B2), is involved in substrate recognition and conversion, with a functionally significant residue 112 in the N-terminal region of human CYP11B2. The inherited disorder glucocorticoid-remediable aldosteronism is caused by a chimeric gene duplication between the CYP11B1 and CYP11B2 genes. This disorder is characterized by hyperaldosteronism and high levels of 18-hydroxycortisol and 18-oxocortisol, which are under ACTH control.
免疫原 :
A synthesized peptide derived from human CYP11B2(Accession P19099), corresponding to amino acid residues M309-T359.
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 1:200, Western Blot: 1:1,000-1:3,000
别名 :
AA389061; ALDOS; Aldosterone synthase; aldosterone-synthesizing enzyme; Corticosterone 18-monooxygenase, CYP11B2; Cp11ba; Cp45as; CPN1; CPN2; CYP11B; CYP11B1; Cyp11b-1; CYP11B2; Cyp11b-2; Cyp11b3; CYP11BL; CYPXIB1; CYPXIB2; CYPXIB3; Cytochrome P450 11B1, mitochondrial; cytochrome P450 11B2, mitochondrial; cytochrome P450 11B3, mitochondrial; cytochrome P450 family 11 subfamily B member 1; cytochrome P450 family 11 subfamily B member 2; Cytochrome P450 subfamily XIB polypeptide 2 (aldosterone synthase); cytochrome p450 XIB1; cytochrome P450(11 beta)-DS; cytochrome P450, family 11, subfamily b, polypeptide 1; cytochrome P450, family 11, subfamily b, polypeptide 2; cytochrome P450, subfamily 11B, polypeptide 1; cytochrome P450, subfamily 11B, polypeptide 2; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2; Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase); Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase); cytochrome P-450Aldo; cytochrome P450-Aldo-1; cytochrome P450-Aldo-2; cytochrome P450C11; Cytochrome P-450c11; cytochrome P-450C18; FHI; mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2; P450(11 beta)-DS; P450aldo; P450-Aldo-1; P450-Aldo-2; P450C11; P450C18; P-450C18; RATCP11BA; RNCP45AS; S11BH; steroid 11-beta/18-hydroxylase; steroid 11-beta-hydroxylase; Steroid 11-beta-hydroxylase, CYP11B1; Steroid 11-beta-hydroxylase, CYP11B2; steroid 11-beta-monooxygenase; Steroid 18-hydroxylase; steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo; steroid-11-beta-hydroxylase
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公司信息
赛默飞世尔