产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD45R单克隆抗体(RA3-6B2), APC
目录 :
RM2605
规格 :
500微升
价格 :
美国278.00
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
APC
克隆名称 :
RA3-6B2
反应物种 :
小鼠
应用 :
免疫细胞化学, 流式细胞仪, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 20
出版应用/物种/样本/稀释参考文献
  • 免疫组化-冰冻切片; 小鼠; 图 1c
Cao A, Alluqmani N, Buhari F, Wasim L, Smith L, Quaile A, et al. Galectin-9 binds IgM-BCR to regulate B cell signaling. Nat Commun. 2018;9:3288 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1c
Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, et al. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. Cell Stem Cell. 2018;22:879-892.e6 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1a
Bröker K, Figge J, Magnusen A, Manz R, Köhl J, Karsten C. A Novel Role for C5a in B-1 Cell Homeostasis. Front Immunol. 2018;9:258 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 4b
Kanayama M, Kato Y, Tsuji T, Konoeda Y, Hashimoto A, Kanauchi O, et al. Enhancement of immunomodulative effect of lactic acid bacteria on plasmacytoid dendritic cells with sucrose palmitate. Sci Rep. 2018;8:3147 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 5
Morales D, Monte K, Sun L, Struckhoff J, Agapov E, Holtzman M, et al. Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice. J Virol. 2015;89:337-49 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 5
Guo Z, Li H, Han M, Xu T, Wu X, Zhuang Y. Modeling Sjögren's syndrome with Id3 conditional knockout mice. Immunol Lett. 2011;135:34-42 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 4
Wells J, Cowled C, Farzaneh F, Noble A. Combined triggering of dendritic cell receptors results in synergistic activation and potent cytotoxic immunity. J Immunol. 2008;181:3422-31 pubmed
  • 流式细胞仪; 小鼠; 图 6
Kaminski D, Stavnezer J. Antibody class switching differs among SJL, C57BL/6 and 129 mice. Int Immunol. 2007;19:545-56 pubmed
  • 流式细胞仪; 小鼠; 图 1
Kaminski D, Stavnezer J. Enhanced IgA class switching in marginal zone and B1 B cells relative to follicular/B2 B cells. J Immunol. 2006;177:6025-9 pubmed
  • 流式细胞仪; 小鼠
Silver K, Ferry H, Crockford T, Cornall R. TLR4, TLR9 and MyD88 are not required for the positive selection of autoreactive B cells into the primary repertoire. Eur J Immunol. 2006;36:1404-12 pubmed
  • 流式细胞仪; 小鼠; 图 2
Lian Z, Kikuchi K, Yang G, Ansari A, Ikehara S, Gershwin M. Expansion of bone marrow IFN-alpha-producing dendritic cells in New Zealand Black (NZB) mice: high level expression of TLR9 and secretion of IFN-alpha in NZB bone marrow. J Immunol. 2004;173:5283-9 pubmed
  • 流式细胞仪; 小鼠; 图 4
Lan F, Zeng D, Higuchi M, Higgins J, Strober S. Host conditioning with total lymphoid irradiation and antithymocyte globulin prevents graft-versus-host disease: the role of CD1-reactive natural killer T cells. Biol Blood Marrow Transplant. 2003;9:355-63 pubmed
  • 流式细胞仪; 小鼠; 图 2
Cabatingan M, Schmidt M, Sen R, Woodland R. Naive B lymphocytes undergo homeostatic proliferation in response to B cell deficit. J Immunol. 2002;169:6795-805 pubmed
  • 流式细胞仪; 小鼠; 图 3
Pan L, Hanrahan J, Li J, Hale L, Zhuang Y. An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus. J Immunol. 2002;168:3923-32 pubmed
  • 流式细胞仪; 小鼠; 图 1, 2
Lan F, Zeng D, Higuchi M, Huie P, Higgins J, Strober S. Predominance of NK1.1+TCR alpha beta+ or DX5+TCR alpha beta+ T cells in mice conditioned with fractionated lymphoid irradiation protects against graft-versus-host disease: "natural suppressor" cells. J Immunol. 2001;167:2087-96 pubmed
  • 流式细胞仪; 小鼠
Lan F, Zeng D, Huie P, Higgins J, Strober S. Allogeneic bone marrow cells that facilitate complete chimerism and eliminate tumor cells express both CD8 and T-cell antigen receptor-alphabeta. Blood. 2001;97:3458-65 pubmed
  • 流式细胞仪; 小鼠; 图 1
Ohmura K, Kawamoto H, Lu M, Ikawa T, Ozaki S, Nakao K, et al. Immature multipotent hemopoietic progenitors lacking long-term bone marrow-reconstituting activity in the aorta-gonad-mesonephros region of murine day 10 fetuses. J Immunol. 2001;166:3290-6 pubmed
Guikema J, Schrader C, Brodsky M, Linehan E, Richards A, El Falaky N, et al. p53 represses class switch recombination to IgG2a through its antioxidant function. J Immunol. 2010;184:6177-87 pubmed 出版商
Guikema J, Schrader C, Leus N, Ucher A, Linehan E, Werling U, et al. Reassessment of the role of Mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching. J Immunol. 2008;181:8450-9 pubmed
Guikema J, Linehan E, Tsuchimoto D, Nakabeppu Y, Strauss P, Stavnezer J, et al. APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination. J Exp Med. 2007;204:3017-26 pubmed
产品信息
产品类型 :
抗体
产品名称 :
CD45R单克隆抗体(RA3-6B2), APC
目录# :
RM2605
规格 :
500微升
价格 :
美国278.00
克隆性 :
单克隆
纯度 :
纯化
宿主 :
大鼠
反应物种 :
小鼠
应用 :
Flow Cytometry: Assay-dependent
物种 :
小鼠
克隆 :
RA3-6B2
抗体亚型 :
IgG2a, kappa
储存 :
4° C
描述 :
CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists in multiple isoforms as a result of alternative splicing, and these isoforms differ in their extracellular domains, but share identical transmembrane and cytoplasmic domains. Further, these CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. In addition to its role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. Diseases associated with CD45 dysfunction include Severe Combined Immunodeficiency (T-cell negative, B-Cell Negative) and Hepatitis C.
免疫原 :
exon A-specific epitope on CD45
格式 :
液体
应用w/稀释 :
Flow Cytometry: Assay-dependent
别名 :
B220; Cd45; CD45 antigen; CD45R; GP180; Lca; L-CA; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; loc; LY5; Ly-5; Lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; Ptprc; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国