产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD45R Monoclonal Antibody (RA3-6B2), Pacific Orange
目录 :
RM2630
规格 :
1毫升
价格 :
406美元
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
pacific orange
克隆名称 :
RA3-6B2
反应物种 :
小鼠
应用 :
流式细胞仪
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 8
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠; 图 2
Pylayeva Gupta Y, Das S, Handler J, Hajdu C, Coffre M, Koralov S, et al. IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia. Cancer Discov. 2016;6:247-55 pubmed 出版商
  • 流式细胞仪; 小鼠
Smolarchuk C, Zhu L, Chan W, Anderson C. T cells generated in the absence of a thoracic thymus fail to establish homeostasis. Eur J Immunol. 2014;44:2263-73 pubmed 出版商
Marcandalli J, Fiala B, Ols S, Perotti M, De van der Schueren W, Snijder J, et al. Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus. Cell. 2019;176:1420-1431.e17 pubmed 出版商
Svedova J, Tsurutani N, Liu W, Khanna K, Vella A. TNF and CD28 Signaling Play Unique but Complementary Roles in the Systemic Recruitment of Innate Immune Cells after Staphylococcus aureus Enterotoxin A Inhalation. J Immunol. 2016;196:4510-21 pubmed 出版商
Pugh J, Foster S, Sukhina A, Petravic J, Uhrlaub J, Padilla Torres J, et al. Acute systemic DNA damage in youth does not impair immune defense with aging. Aging Cell. 2016;15:686-93 pubmed 出版商
Bökers S, Urbat A, Daniel C, Amann K, Smith K, Espéli M, et al. Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice. J Immunol. 2014;192:2994-3002 pubmed 出版商
Kipari T, Hadoke P, Iqbal J, Man T, Miller E, Coutinho A, et al. 11?-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis. FASEB J. 2013;27:1519-31 pubmed 出版商
Gatto D, Wood K, Brink R. EBI2 operates independently of but in cooperation with CXCR5 and CCR7 to direct B cell migration and organization in follicles and the germinal center. J Immunol. 2011;187:4621-8 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
CD45R Monoclonal Antibody (RA3-6B2), Pacific Orange
目录# :
RM2630
规格 :
1毫升
价格 :
406美元
克隆性 :
单克隆
纯度 :
纯化
宿主 :
大鼠
反应物种 :
小鼠
应用 :
Flow Cytometry: Assay Dependent
物种 :
小鼠
克隆 :
RA3-6B2
抗体亚型 :
IgG2a, kappa
储存 :
4° C
描述 :
CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists in multiple isoforms as a result of alternative splicing, and these isoforms differ in their extracellular domains, but share identical transmembrane and cytoplasmic domains. Further, these CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. In addition to its role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. Diseases associated with CD45 dysfunction include Severe Combined Immunodeficiency (T-cell negative, B-Cell Negative) and Hepatitis C.
免疫原 :
exon A-specific epitope on CD45
格式 :
液体
应用w/稀释 :
Flow Cytometry: Assay Dependent
别名 :
B220; Cd45; CD45 antigen; CD45R; GP180; Lca; L-CA; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; loc; LY5; Ly-5; Lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; PTPRC; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国