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抗体

亲环素类B多克隆抗体

TAB1002

100微克

美国386

多克隆

domestic rabbit

未共轭

人类, 小鼠

免疫印迹, 免疫细胞化学

亲环素类B多克隆抗体

TAB1002

100微克

美国386

多克隆

纯化

兔

人类, 小鼠

Immunocytochemistry: 2 µg/mL, Western Blot: 0.1-1 µg/mL

人类, 小鼠

IgG

4° C, store in dark, DO NOT FREEZE!

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.

KLH conjugated peptide representing human cyclophilin B.

液体

Immunocytochemistry: 2 µg/mL, Western Blot: 0.1-1 µg/mL

AA408962; AA553318; AI844835; Cphn2; Cphn-2; cyclophilin B; cyclophilin-like protein; Cyp B; CyP-20b; CYPB; CYP-S1; EC 5.2.1.8; epididymis secretory protein Li 39; HEL-S-39; OI9; Peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B; peptidylprolyl isomerase B (cyclophilin B); PPIase; PPIase B; Ppib; Rotamase; Rotamase B; S-cyclophilin; S-cyclophylin; SCYLP