产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
TCR gamma/delta Monoclonal Antibody (5A6.E9)
目录 :
TCR1061
规格 :
200微克
价格 :
美国452
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
5A6.E9
反应物种 :
domestic goat, African green monkey, 人类, 小鼠, 家羊, 猕猴
应用 :
免疫组化, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 抑制或激活实验
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 54
出版应用/物种/样本/稀释参考文献
  • 抑制或激活实验; 人类; 图 2a
Ribeiro S, Tesio M, Ribot J, Macintyre E, Barata J, Silva Santos B. Casein kinase 2 controls the survival of normal thymic and leukemic ?? T cells via promotion of AKT signaling. Leukemia. 2017;31:1603-1610 pubmed 出版商
  • 流式细胞仪; 人类; 表 1
Sumatoh H, Teng K, Cheng Y, Newell E. Optimization of mass cytometry sample cryopreservation after staining. Cytometry A. 2017;91:48-61 pubmed 出版商
  • 流式细胞仪; African green monkey; 图 2a
Neumann B, Shi T, Gan L, Klippert A, Daskalaki M, Stolte Leeb N, et al. Comprehensive panel of cross-reacting monoclonal antibodies for analysis of different immune cells and their distribution in the common marmoset (Callithrix jacchus). J Med Primatol. 2016;45:139-46 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Tanaka T, Yamamoto H, Elsayed A, Satou A, Asano N, Kohno K, et al. Clinicopathologic Spectrum of Gastrointestinal T-cell Lymphoma: Reappraisal Based on T-cell Receptor Immunophenotypes. Am J Surg Pathol. 2016;40:777-85 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 4
Kim J, Choi Y, Lee B, Song M, Ban C, Kim J, et al. Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1-high T cells. J Allergy Clin Immunol. 2016;137:1466-1476.e3 pubmed 出版商
  • 流式细胞仪; 人类; 2:25; 图 1
Leong M, Newell E. Multiplexed Peptide-MHC Tetramer Staining with Mass Cytometry. Methods Mol Biol. 2015;1346:115-31 pubmed 出版商
  • 免疫组化; 人类; 表 2
Satou A, Asano N, Kato S, Katsuya H, Ishitsuka K, Elsayed A, et al. FoxP3-positive T cell lymphoma arising in non-HTLV1 carrier: clinicopathological analysis of 11 cases of PTCL-NOS and 2 cases of mycosis fungoides. Histopathology. 2016;68:1099-108 pubmed 出版商
  • 免疫组化; 人类; 表 2
Tomita S, Kikuti Y, Carreras J, Kojima M, Ando K, Takasaki H, et al. Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan. Mod Pathol. 2015;28:1286-96 pubmed 出版商
  • 免疫组化-冰冻切片; 人类; 1:100; 图 2
Owens G, Erickson K, Malone C, Pan C, Huynh M, Chang J, et al. Evidence for the involvement of gamma delta T cells in the immune response in Rasmussen encephalitis. J Neuroinflammation. 2015;12:134 pubmed 出版商
  • 免疫组化; 人类; 表 4
Kato S, Asano N, Miyata Takata T, Takata K, Elsayed A, Satou A, et al. T-cell receptor (TCR) phenotype of nodal Epstein-Barr virus (EBV)-positive cytotoxic T-cell lymphoma (CTL): a clinicopathologic study of 39 cases. Am J Surg Pathol. 2015;39:462-71 pubmed 出版商
  • 免疫组化; 人类; 1:20
Hayashi E, Takata K, Sato Y, Tashiro Y, Tachiyama Y, Sawada Kitamura S, et al. Distinct morphologic, phenotypic, and clinical-course characteristics of indolent peripheral T-cell lymphoma. Hum Pathol. 2013;44:1927-36 pubmed 出版商
  • 流式细胞仪; 人类; 图 1
Thai P, Collins C, Fortner K, Koenig A, Hayes S, Budd R. Increased caspase activity primes human Lyme arthritis synovial ?? T cells for proliferation and death. Hum Immunol. 2011;72:1168-75 pubmed 出版商
  • 免疫组化; 人类
Garcia Herrera A, Song J, Chuang S, Villamor N, Colomo L, Pittaluga S, et al. Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation. Am J Surg Pathol. 2011;35:1214-25 pubmed 出版商
  • 免疫组化; 人类
Dimova T, Nagaeva O, Stenqvist A, Hedlund M, Kjellberg L, Strand M, et al. Maternal Foxp3 expressing CD4+ CD25+ and CD4+ CD25- regulatory T-cell populations are enriched in human early normal pregnancy decidua: a phenotypic study of paired decidual and peripheral blood samples. Am J Reprod Immunol. 2011;66 Suppl 1:44-56 pubmed 出版商
  • 流式细胞仪; 猕猴; 表 1
Neves P, Rudersdorf R, Galler R, Bonaldo M, de Santana M, Mudd P, et al. CD8+ gamma-delta TCR+ and CD4+ T cells produce IFN-? at 5-7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses. Vaccine. 2010;28:8183-8 pubmed 出版商
  • 抑制或激活实验; 人类
Gold M, Cerri S, Smyk Pearson S, Cansler M, Vogt T, Delepine J, et al. Human mucosal associated invariant T cells detect bacterially infected cells. PLoS Biol. 2010;8:e1000407 pubmed 出版商
  • 流式细胞仪; 人类
Vinh D, Patel S, Uzel G, Anderson V, Freeman A, Olivier K, et al. Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia. Blood. 2010;115:1519-29 pubmed 出版商
  • 流式细胞仪; 人类
Qin G, Mao H, Zheng J, Sia S, Liu Y, Chan P, et al. Phosphoantigen-expanded human gammadelta T cells display potent cytotoxicity against monocyte-derived macrophages infected with human and avian influenza viruses. J Infect Dis. 2009;200:858-65 pubmed 出版商
  • 流式细胞仪; 人类
Hedlund M, Stenqvist A, Nagaeva O, Kjellberg L, Wulff M, Baranov V, et al. Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function. J Immunol. 2009;183:340-51 pubmed 出版商
  • 免疫组化; 人类; 1:50
Hölttä V, Klemetti P, Sipponen T, Westerholm Ormio M, Kociubinski G, Salo H, et al. IL-23/IL-17 immunity as a hallmark of Crohn's disease. Inflamm Bowel Dis. 2008;14:1175-84 pubmed 出版商
  • 流式细胞仪; domestic goat
  • 流式细胞仪; 家羊
Conrad M, Davis W, Koop B. TCR and CD3 antibody cross-reactivity in 44 species. Cytometry A. 2007;71:925-33 pubmed
  • 流式细胞仪; 人类
Kalmbach Y, Boldt A, Fendel R, Mordmuller B, Kremsner P, Kun J. Increase in annexin V-positive B cells expressing LILRB1/ILT2/CD85j in malaria. Eur Cytokine Netw. 2006;17:175-80 pubmed
  • 流式细胞仪; 人类
Agea E, Russano A, Bistoni O, Mannucci R, Nicoletti I, Corazzi L, et al. Human CD1-restricted T cell recognition of lipids from pollens. J Exp Med. 2005;202:295-308 pubmed
  • 流式细胞仪; African green monkey
Cairo C, Propp N, Hebbeler A, Colizzi V, Pauza C. The Vgamma2/Vdelta2 T-cell repertoire in Macaca fascicularis: functional responses to phosphoantigen stimulation by the Vgamma2/Jgamma1.2 subset. Immunology. 2005;115:197-205 pubmed
  • 免疫组化; 人类
Buri C, Burri P, Bähler P, Straumann A, Müller Schenker B, Birrer S, et al. Cytotoxic T cells are preferentially activated in the duodenal epithelium from patients with florid coeliac disease. J Pathol. 2005;206:178-85 pubmed
  • 流式细胞仪; 人类
Green A, Lissina A, Hutchinson S, Hewitt R, Temple B, James D, et al. Recognition of nonpeptide antigens by human V gamma 9V delta 2 T cells requires contact with cells of human origin. Clin Exp Immunol. 2004;136:472-82 pubmed
  • 流式细胞仪; 人类; 图 1
Roessner K, Wolfe J, Shi C, Sigal L, Huber S, Budd R. High expression of Fas ligand by synovial fluid-derived gamma delta T cells in Lyme arthritis. J Immunol. 2003;170:2702-10 pubmed
  • 流式细胞仪; 人类; 图 1
Sieling P, Porcelli S, Duong B, Spada F, Bloom B, Diamond B, et al. Human double-negative T cells in systemic lupus erythematosus provide help for IgG and are restricted by CD1c. J Immunol. 2000;165:5338-44 pubmed
  • 流式细胞仪; 人类; 图 1
Sieling P, Ochoa M, Jullien D, Leslie D, Sabet S, Rosat J, et al. Evidence for human CD4+ T cells in the CD1-restricted repertoire: derivation of mycobacteria-reactive T cells from leprosy lesions. J Immunol. 2000;164:4790-6 pubmed
  • 流式细胞仪; 人类
Vincent M, Roessner K, Sellati T, Huston C, Sigal L, Behar S, et al. Lyme arthritis synovial gamma delta T cells respond to Borrelia burgdorferi lipoproteins and lipidated hexapeptides. J Immunol. 1998;161:5762-71 pubmed
Rodriguez L, Pekkarinen P, Lakshmikanth T, Tan Z, Consiglio C, Pou C, et al. Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19. Cell Rep Med. 2020;1:100078 pubmed 出版商
Daniels J, Doukas P, Escala M, Ringbloom K, Shih D, Yang J, et al. Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas. Nat Commun. 2020;11:1806 pubmed 出版商
van Beek J, Flórez Grau G, Gorris M, Mathan T, Schreibelt G, Bol K, et al. Human pDCs Are Superior to cDC2s in Attracting Cytolytic Lymphocytes in Melanoma Patients Receiving DC Vaccination. Cell Rep. 2020;30:1027-1038.e4 pubmed 出版商
Li X, Wang Z, Chang L, Chen X, Yang L, Lai X, et al. γδT cells contribute to type 2 inflammatory profiles in eosinophilic chronic rhinosinusitis with nasal polyps. Clin Sci (Lond). 2019;133:2301-2315 pubmed 出版商
Lee M, Park C, Woo J, Kim J, Kho I, Nam D, et al. Preferential Infiltration of Unique Vγ9Jγ2-Vδ2 T Cells Into Glioblastoma Multiforme. Front Immunol. 2019;10:555 pubmed 出版商
Jungbluth A, Frosina D, Fayad M, Pulitzer M, Dogan A, Busam K, et al. Immunohistochemical Detection of γ/δ T Lymphocytes in Formalin-fixed Paraffin-embedded Tissues. Appl Immunohistochem Mol Morphol. 2019;27:581-583 pubmed 出版商
Xu D, Robinson A, Ishii T, Duncan D, Alden T, Goings G, et al. Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy. J Exp Med. 2018;215:1169-1186 pubmed 出版商
Dutta I, Postovit L, Siegers G. Apoptosis Induced via Gamma Delta T Cell Antigen Receptor "Blocking" Antibodies: A Cautionary Tale. Front Immunol. 2017;8:776 pubmed 出版商
Fisher J, Yan M, Heuijerjans J, Carter L, Abolhassani A, Frosch J, et al. Neuroblastoma killing properties of Vδ2 and Vδ2-negative γδT cells following expansion by artificial antigen-presenting cells. Clin Cancer Res. 2014;20:5720-32 pubmed 出版商
Ali Z, Yan L, Plagman N, Reichenberg A, Hintz M, Jomaa H, et al. Gammadelta T cell immune manipulation during chronic phase of simian-human immunodeficiency virus infection [corrected] confers immunological benefits. J Immunol. 2009;183:5407-17 pubmed 出版商
Takeshita M, Imayama S, Oshiro Y, Kurihara K, Okamoto S, Matsuki Y, et al. Clinicopathologic analysis of 22 cases of subcutaneous panniculitis-like CD56- or CD56+ lymphoma and review of 44 other reported cases. Am J Clin Pathol. 2004;121:408-16 pubmed
Seko Y, Sugishita K, Sato O, Takagi A, Tada Y, Matsuo H, et al. Expression of costimulatory molecules (4-1BBL and Fas) and major histocompatibility class I chain-related A (MICA) in aortic tissue with Takayasu's arteritis. J Vasc Res. 2004;41:84-90 pubmed
Brandes M, Willimann K, Lang A, Nam K, Jin C, Brenner M, et al. Flexible migration program regulates gamma delta T-cell involvement in humoral immunity. Blood. 2003;102:3693-701 pubmed
Muench M, Pott Bärtsch E, Chen J, Lopoo J, Barcena A. Ontogenic changes in CD95 expression on human leukocytes: prevalence of T-cells expressing activation markers and identification of CD95-CD45RO+ T-cells in the fetus. Dev Comp Immunol. 2003;27:899-914 pubmed
DeSantis S, Pau C, Archibald L, Nwanyanwu O, Kazembe P, Dobbie H, et al. Demographic and immune correlates of human herpesvirus 8 seropositivity in Malawi, Africa. Int J Infect Dis. 2002;6:266-71 pubmed
Westerholm Ormio M, Garioch J, Ketola I, Savilahti E. Inflammatory cytokines in small intestinal mucosa of patients with potential coeliac disease. Clin Exp Immunol. 2002;128:94-101 pubmed
Hyjek E, Chadburn A, Liu Y, Cesarman E, Knowles D. BCL-6 protein is expressed in precursor T-cell lymphoblastic lymphoma and in prenatal and postnatal thymus. Blood. 2001;97:270-6 pubmed
Korhonen M, Ormio M, Burgeson R, Virtanen I, Savilahti E. Unaltered distribution of laminins, fibronectin, and tenascin in celiac intestinal mucosa. J Histochem Cytochem. 2000;48:1011-20 pubmed
Rantala I, Collin P, Holm K, Kainulainen H, Mustonen J, Maki M. Small bowel T cells, HLA class II antigen DR, and GroEL stress protein in IgA nephropathy. Kidney Int. 1999;55:2274-80 pubmed
Poccia F, Boullier S, Lecoeur H, Cochet M, Poquet Y, Colizzi V, et al. Peripheral V gamma 9/V delta 2 T cell deletion and anergy to nonpeptidic mycobacterial antigens in asymptomatic HIV-1-infected persons. J Immunol. 1996;157:449-61 pubmed
Kabelitz D, Ackermann T, Hinz T, Davodeau F, Band H, Bonneville M, et al. New monoclonal antibody (23D12) recognizing three different V gamma elements of the human gamma delta T cell receptor. 23D12+ cells comprise a major subpopulation of gamma delta T cells in postnatal thymus. J Immunol. 1994;152:3128-36 pubmed
Band H, Hochstenbach F, McLean J, Hata S, Krangel M, Brenner M. Immunochemical proof that a novel rearranging gene encodes the T cell receptor delta subunit. Science. 1987;238:682-4 pubmed
Rivas A, Koide J, Cleary M, Engleman E. Evidence for involvement of the gamma, delta T cell antigen receptor in cytotoxicity mediated by human alloantigen-specific T cell clones. J Immunol. 1989;142:1840-6 pubmed
Kabelitz D, Bender A, Schondelmaier S, da Silva Lobo M, Janssen O. Human cytotoxic lymphocytes. V. Frequency and specificity of gamma delta+ cytotoxic lymphocyte precursors activated by allogeneic or autologous stimulator cells. J Immunol. 1990;145:2827-32 pubmed
产品信息
产品类型 :
抗体
产品名称 :
TCR gamma/delta Monoclonal Antibody (5A6.E9)
目录# :
TCR1061
规格 :
200微克
价格 :
美国452
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: 1-2 µg/test, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, T-Cell Activation: Assay-dependent
物种 :
人类
克隆 :
5A6.E9
抗体亚型 :
IgG1
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory auto-destructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). However, a small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
免疫原 :
Human leukemic PEER cells
格式 :
液体
应用w/稀释 :
Flow Cytometry: 1-2 µg/test, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, T-Cell Activation: Assay-dependent
别名 :
RGD1311300; similar to T cell receptor V delta 6; T cell receptor gamma locus; T3/TCR complex; TCR delta gamma; TCR gamma/delta; TCR-CD3 complex; Tcrg; Trg; Trg@
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国