产品简要
公司名称 :
LifeSpan Biosciences
产品类型 :
抗体
产品名称 :
IHC-plus™ PARP1 Antibody (clone A6.4.12) LS-B3432
目录 :
LS-B3432
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
A6.4.12
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
LifeSpan Biosciences 产品网页
文章摘录数: 1
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 5c, 7e
Zheng J, Croteau D, Bohr V, Akbari M. Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells. Nucleic Acids Res. 2019;: pubmed 出版商
图像
图像 1 :
LifeSpan Biosciences LS-B3432 图像 1
Anti-PARP antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
产品信息
抗体编号 :
106104
抗体名称 :
LS-B3432
目标物种 :
人类
宿主物种 :
小鼠
产品名称 :
IHC-plus™ PARP1 Antibody (clone A6.4.12) LS-B3432
特异性 :
Recognizes poly (ADP-ribose) polymerase 1 (PARP-1), a ~116kD nuclear enzyme cleaved during apoptosis. PARP-1, a caretaker enzyme, is involved in DNA damage repair, plays roles in diabetes pathophysiology and tumor proliferation.). As well as protecting cells from genomic instability, PARP-1 is involved in the development of both inflammatory and immune responses, and cell death by apoptosis and necrosis. Targets PARP-1, an enzyme which represents a promising target for new developments in therapeutic treatment of immune mediated diseases. PARP-1 has considerable potential for delivering selective tumor cell killing while sparing normal cells.
克隆描述 :
单克隆
克隆名称 :
A6.4.12
抗体修饰 :
未共轭
样品状态 :
PBS, 0.09% 叠氮化钠
免疫原类型 :
纯化蛋白
免疫原描述 :
人类PARP
纯化描述 :
蛋白质G纯化
推荐的储存条件 :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
抗体亚型 :
IgG1
基因 :
多聚(ADP-核糖)聚合酶
标准基因符号 :
多聚(ADP-核糖)聚合酶
反应物种 :
人类
用途 :
ELISA (1:1000 - 1:5000), IF, IHC, IHC-Fr, IHC-P (10 µg/ml), IP, WB
ShortWebDescription :
PARP1 antibody LS-B3432 is an unconjugated mouse monoclonal antibody to human PARP1. Validated for ELISA, IF, IHC, IP and WB. Tested on 20 paraffin-embedded human tissues.
使用文本 :
Immunohistochemistry: LS-B3432 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B3432 was determined to be 10 ug/ml.
同义词 :
PARP1, ADPRT, ADP-ribosyltransferase NAD(+), Adp-ribosyltransferase, ADPRT1, ARTD1, ADPRT 1, Poly(ADP-ribose) synthetase, Poly(ADP-ribosyl)transferase, PARP, Poly [ADP-ribose] polymerase 1, PADPRT-1, PARP-1, Poly (ADP-ribose) polymerase 1, Poly(ADP-ribose) polymerase, Poly[ADP-ribose] synthase 1, PPOL
SalesRegion :
Worldwide
更多信息或购买 :
LifeSpan Biosciences 产品网页
公司信息
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
antibodies@lsbio.com
https://www.lsbio.com
1-206-464-1554
公司总部: 美国
LifeSpan成立于1995年，已经成为分子病理学领域的领导品牌，专注于人和其他物种的正常和疾病组织中蛋白的定位情况。我们提供超过74000种抗体，定制的免疫组化研究服务，超过500种蛋白研究用人免疫组化材料，及组化和病理学服务；提供2,000,000样本，包括冰冻及石蜡切片的正常和疾病组织，进行对外研究服务。对外服务项目范围广泛，由LifeSpan的病理学家提供包括课题设计、抗体搜寻及表征、组织搜集和验证、免疫标记、问题处理及结果处理等诸多环节。