产品简要
公司名称 :
LifeSpan Biosciences
产品类型 :
抗体
产品名称 :
IHC-plus™ NCAM / CD56 Antibody (clone 123C3, Concentrated) LS-B5569
目录 :
LS-B5569
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
123C3
反应物种 :
人类
应用 :
免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 1
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 人类
Deborde S, Omelchenko T, Lyubchik A, Zhou Y, He S, McNamara W, et al. Schwann cells induce cancer cell dispersion and invasion. J Clin Invest. 2016;126:1538-54 pubmed 出版商
图像
图像 1 :
LifeSpan Biosciences LS-B5569 图像 1
Anti-CD56 antibody IHC of human brain cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
产品信息
抗体编号 :
140175
抗体名称 :
LS-B5569
目标物种 :
人类
宿主物种 :
小鼠
产品名称 :
IHC-plus™ NCAM / CD56 Antibody (clone 123C3, Concentrated) LS-B5569
特异性 :
The antibody recognizes a transmembrane glycoprotein of 140 and 180 kD which has been identified as NCAM (Neural Cell Adhesion Module). It is involved in intercellular adhesion and play a role in outgrowth of neurites and the development of the nervous system. Several other isoforms have been identified which are expressed in a developmental and tissue specific pattern. Two major epitopes have been defined, NKI-nbl-1 (MON 9012) reacts with epitope 1 and 123C3 (MON 9006) reacts with epitope 2. At the international Workshop on SCLC antibodies 123C3 has been categorized as cluster 1 antibody (Stahel et al 1994). Most importantly, 123C3 can be used on routing formalin fixed paraffin section after retrieval. All cells in small cell carcinomas and carcinoids of the lung are strongly positive for 123C3. A minority of cases of other major types of lung carcinoma are sometimes positive as well: however this positivity is generally weak and focal. Adenoid cystic carcinomas of bronchial glands are strongly positive. Neuroblastoma's and Wilms tumors are usually also staining strongly positive. In non small lung cell carcinomas, 123C3 staining has been associated with more advanced stage and a decreased survival after surgery (Kibbelaar et al. 1991). Positive staining with other tumors, include medullary thyroid carcinomas and some ovarian tumors. NCAM (CD56) is a marker for natural killer: 123C3 can be used to distinguish NK cells from other hematopoietic cell populations. Although .
克隆描述 :
单克隆
克隆名称 :
123C3
抗体修饰 :
Concentrated Unconjugated
样品状态 :
PBS, 0.02% 叠氮化钠, 0.1% BSA
免疫原类型 :
重组蛋白
纯化描述 :
纯化
推荐的储存条件 :
存放在2-8°C
抗体亚型 :
IgG1
基因 :
NCAM/CD56
标准基因符号 :
神经细胞粘附分子1
家族 :
免疫球蛋白
反应物种 :
人类
用途 :
IF, IHC, IHC-Fr, IHC-P (1:100)
ShortWebDescription :
CD56 antibody LS-B5569 is an unconjugated mouse monoclonal antibody to human CD56 (NCAM). Validated for IF and IHC. Tested on 20 paraffin-embedded human tissues. Cited in 1 publication.
使用文本 :
Study of small cell carcinoma. Detection of CD56 positive lymphomas. For immunofluorescence and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10, formalin fixed paraffin sections should be pretreated in microwave or pressure cooker.
同义词 :
神经细胞粘附分子1, CD56, CD56抗原, MSK39, NCAM-1, N-CAM-1, NCAM
SalesRegion :
Worldwide
更多信息或购买 :
公司信息
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
antibodies@lsbio.com
https://www.lsbio.com
1-206-464-1554
公司总部: 美国
LifeSpan成立于1995年,已经成为分子病理学领域的领导品牌,专注于人和其他物种的正常和疾病组织中蛋白的定位情况。我们提供超过74000种抗体,定制的免疫组化研究服务,超过500种蛋白研究用人免疫组化材料,及组化和病理学服务;提供2,000,000样本,包括冰冻及石蜡切片的正常和疾病组织,进行对外研究服务。对外服务项目范围广泛,由LifeSpan的病理学家提供包括课题设计、抗体搜寻及表征、组织搜集和验证、免疫标记、问题处理及结果处理等诸多环节。