抗体

EDN1/内皮素1抗体(C末端, 克隆IC4)LS-C11319

LS-C11319

单克隆

小鼠

未共轭

IC4

primate, 人类, 猕猴

免疫组化, 免疫组化-冰冻切片

LS-C11319

人类

小鼠

EDN1/内皮素1抗体(C末端, 克隆IC4)LS-C11319

Recognizes human endothelin 1 (ET-1). Endothelin-1 in it's precursor form is a 212 amino acid protein with a 17 aa signal peptide, an N-terminal pro-peptide region and a C-terminal pro-peptide region flanking the endothelin peptides, big endothelin-1 (38aa), the precursor of the smaller endothelin peptide which is cleaved by endothelin converting enzyme to produce the active endothelin-1 (21aa) peptide and a c-terminal fragment. Endothelin-1 is a potent vasoconstrictor with a molecular weight of approximately 25 kD. Shows less than 10% reactivity with endothelin 3. Plasma levels of both endothelin-1 and big endothelin-1 are useful as predictors for survival of patients with congestive heart failure. However, the half life of the endothlin1 peptide in human plasma is very short (c1.0mins) and measurement of big-endothelin-1 may be a more reliable measure of the endothelin secretory pathway activity.

单克隆

IC4

未共轭

C末端

PBS, 0.1% 叠氮化钠

C-Terminus fragment of human endothelin 1.

蛋白质A纯化

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

IgG1

EDN1/内皮素1

EDN1

激素

人类

IHC, IHC-Fr, IRMA

Endothelin 1 antibody LS-C11319 is an unconjugated mouse monoclonal antibody to human Endothelin 1 (EDN1) (C-Terminus). Validated for IHC and IRMA. Cited in 1 publication.

EDN1, 内皮素1, 内皮素1, ET1, 前内皮素原1, PPET1, HDLCQ7

Worldwide