产品简要
公司名称 :
LifeSpan Biosciences
产品类型 :
抗体
产品名称 :
ER Alpha / Estrogen Receptor Antibody (clone 6F11, Supernatant) LS-C11577
目录 :
LS-C11577
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
6F11
反应物种 :
人类
应用 :
免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
产品信息
抗体编号 :
12318
抗体名称 :
LS-C11577
目标物种 :
人类
宿主物种 :
小鼠
产品名称 :
ER Alpha / Estrogen Receptor Antibody (clone 6F11, Supernatant) LS-C11577
特异性 :
Recognizes the human estrogen receptor alpha chain (ERalpha), also known as the estradiol receptor or nuclear receptor subfamily 3 group A member 1. ERalpha is a ~65kD steroid hormone receptor containing an N-terminal. ligand independent transactivation domain, a DNA binding domain and a C-terminal ligand binding domain which overlaps with an. ERalpha binds to DNA as a homodimer and can also form heterodimers with Estrogen receptor beta The detection of estrogen (ER) and progesterone (PR) receptors using immunohistochemical staining of formalin fixed, paraffin embedded (FFPE) tissue, has gradually replaced ligand binding assays, to become the most common method for the determination of the ER/PR status of breast tumors. Approximately 75% to 80% of breast tumors have estrogen and/or progesterone receptors, and the presence of these receptors helps determine both the patients prognosis and the effectiveness of hormonal therapy. Has been used successfully for identification of ERalpha on breast cancer cell lysates using Western blotting and for the immunohistochemical detection of ERalpha in breast cancer tissues.
克隆描述 :
单克隆
克隆名称 :
6F11
抗体修饰 :
Supernatant Unconjugated
样品状态 :
0.09% 叠氮化钠
免疫原类型 :
重组蛋白
免疫原描述 :
重组人类雌激素受体(甲形式)
纯化描述 :
Tissue culture supernatant
推荐的储存条件 :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
重悬液体 :
1 ml Distilled Water.
抗体亚型 :
IgG1
基因 :
ER甲/雌激素受体
标准基因符号 :
ESR1
家族 :
NHR
亚家族 :
NR3类固醇激素受体
反应物种 :
人类
用途 :
IHC-Fr (1:40 - 1:60), IHC-P (1:40 - 1:80)
ShortWebDescription :
Estrogen Receptor antibody LS-C11577 is an unconjugated mouse monoclonal antibody to human Estrogen Receptor (ER Alpha). Validated for IHC.
使用文本 :
Immunohistology: Zamboni's fixative recommended for best results. #This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH6.0 is recommended for this purpose.
同义词 :
ESR1, Era, ERalpha, Estrogen receptor, ER-alpha, Estrogen receptor 1, NR3A1, ER, ESR, ESRA, Estrogen receptor alpha
SalesRegion :
Worldwide
更多信息或购买 :
公司信息
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
Seattle, WA 98121
antibodies@lsbio.com
https://www.lsbio.com1-206-464-1554
公司总部: 美国
LifeSpan成立于1995年，已经成为分子病理学领域的领导品牌，专注于人和其他物种的正常和疾病组织中蛋白的定位情况。我们提供超过74000种抗体，定制的免疫组化研究服务，超过500种蛋白研究用人免疫组化材料，及组化和病理学服务；提供2,000,000样本，包括冰冻及石蜡切片的正常和疾病组织，进行对外研究服务。对外服务项目范围广泛，由LifeSpan的病理学家提供包括课题设计、抗体搜寻及表征、组织搜集和验证、免疫标记、问题处理及结果处理等诸多环节。