抗体

MMP1抗体(C末端, 克隆3B6)LS-C188387

LS-C188387

单克隆

小鼠

未共轭

3B6

免疫印迹, 免疫组化-石蜡切片

LS-C188387

人类

小鼠

MMP1抗体(C末端, 克隆3B6)LS-C188387

Recognizes human matrix metalloproteinase 1 (MMP-1). The MMPs are zinc-dependent endopeptidases responsible for degrading the extracellular matrix. They are also involved in cell proliferation, migration, differentiation and apoptosis. Most MMPs are synthesized as inactive zymogens and a propeptide region must be cleaved off before the enzyme becomes active. Their expression is increased dramatically in a variety of cancer types, where it indicates invasive disease and a poor prognosis. MMP-1 is one of the collagenases, capable of degrading collagens I, II and III, all main components of the interstitial stroma. It is overexpressed in invasive melanoma, colorectal and esophageal cancers. It has also been implicated in arthritis and might influence atherosclerotic lesion formation. It might also be involved in the repair processes of the heart after myocardial infarction.

单克隆

3B6

未共轭

C末端

PBS, 0.09% 叠氮化钠

合成肽

Ovalbumin conjugated synthetic peptide corresponding to a region within the C-Terminus of human MMP-1.

蛋白质G纯化

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

IgG1

MMP1

MMP1

蛋白酶

金属肽酶M10A

人类

免疫组化-P, 免疫印迹

MMP1 antibody LS-C188387 is an unconjugated mouse monoclonal antibody to human MMP1 (C-Terminus). Validated for IHC and WB.

MMP1, CLG, Matrix metalloprotease 1, MMP-1, Interstitial collagenase, Matrix metalloproteinase 1, Matrix metalloproteinase-1

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