抗体

TP53 / p53 Antibody (clone Pab122, Concentrated) LS-C202480

LS-C202480

单克隆

小鼠

未共轭

Pab122

免疫印迹, 酶联免疫吸附测定, 免疫组化, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片

LS-C202480

人类

小鼠

TP53 / p53 Antibody (clone Pab122, Concentrated) LS-C202480

The p53 gene is located on human chromosome 17p13.1. Mutation and/or allelic loss of this gene is one of the causes of the occurrence of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. P53 binds to a DNA consensus sequence, the p53 response element, and it regulates normal cell growth cycle events by activating transcription of genes, involved either in progression through the cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 5-1000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). P53 localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution.

单克隆

Pab122

Concentrated Unconjugated

PBS, 0.05% 叠氮化钠

重组蛋白

Recombinant human p53 protein. Splenocytes were fused with mouse myeloma P3-X63/AG8.653 cells.

纯化

存放在2-8°C

IgG1, k

TP53/p53

TP53

P53

人类

ELISA, Flo, IHC, IHC-Fr, IHC-P, WB

P53 antibody LS-C202480 is an unconjugated mouse monoclonal antibody to human p53 (TP53). Validated for ELISA, Flow, IHC and WB.

TP53, BCC7, Cellular tumor antigen p53, p53, TRP53, p53 tumor suppressor, Phosphoprotein p53, Antigen NY-CO-13, Tumor protein p53, Tumor suppressor p53, LFS1

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