抗体

表皮生长因子受体抗体(克隆H9B4)LS-C357865

LS-C357865

单克隆

小鼠

未共轭

H9B4

免疫印迹, 酶联免疫吸附测定, 免疫沉淀

LS-C357865

人类

小鼠

表皮生长因子受体抗体(克隆H9B4)LS-C357865

人类表皮生长因子受体

单克隆

H9B4

未共轭

1X PBS, 0.1毫克/毫升BSA, 0.05% 叠氮化钠

细胞

纯化表皮生长因子受体来自A431细胞

蛋白质G纯化

Store at 2°C to 8°C.

IgG1

表皮生长因子受体

表皮生长因子受体

蛋白激酶

EGF受体

人类

小鼠, 大鼠

酶联免疫吸附测定, 免疫沉淀, 免疫印迹(0.5-1微克/毫升)

EGFR antibody LS-C357865 is an unconjugated mouse monoclonal antibody to human EGFR. Validated for ELISA, IP and WB.

Epidermal Growth Factor Receptor is a type I receptor tyrosine kinase, referred to as . EGFR , ErbB1 and HER1. When EGFR is activated by one of its ligands, it dimerizes. It can form a homodimer, heterodimers with other ErbB family members, or even a cluster of EGFRs. Activation stimulates EGFRs intracellular kinase activity. Autophosphorylation of tyrosine residues in the C-terminal domain of EGFR leads to association with proteins with phosphotyrosine-binding domains which then signal the initiation of signal transduction cascades including the JNK, MAPK, AKT, and possibly . Nf-KB , pathways. Overexpression of EGFR is the cause of some types of cancer, including lung and colon cancer. It has also been linked to psoriasis, eczema and atherosclerosis, although poorly defined. Monoclonal antibody to EGFR can be used to block the extracellular ligand binding domain, therebye blocking tyrosine kinase activation and subsequent signal transduction. ELISA: Order BSA-free antibody format for coating.

EGFR, EGF Receptor, ERBB, ERBB1, MENA, PIG61, Proto-oncogene c-ErbB-1, V-erb-b homolog, EGF-R, HER1

Worldwide