产品简要
公司名称 :
LifeSpan Biosciences
产品类型 :
抗体
产品名称 :
RNF126抗体(aa39-225)LS-C499668
目录 :
LS-C499668
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学
更多信息或购买 :
图像
图像 1 :
Positive WB detected in:Mouse brain tissue;All lanes:RNF126 antibody at 2.7?g/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 36,34 KDa;Observed band size: 36 KDa;
图像 2 :
Immunohistochemistry of paraffin-embedded human testis tissue using RNF126 Antibody at dilution of 1:100
图像 3 :
Immunofluorescent analysis of HepG2 cells using RNF126 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
产品信息
抗体编号 :
513182
抗体名称 :
LS-C499668
目标物种 :
人类
宿主物种 :
兔
产品名称 :
RNF126抗体(aa39-225)LS-C499668
特异性 :
E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).
克隆描述 :
多克隆
抗体修饰 :
未共轭
抗原修饰 :
aa39-225
样品状态 :
PBS, pH值7.4, 0.03% ProClin防腐剂300, 50% 甘油
免疫原类型 :
重组蛋白
免疫原描述 :
重组人类E3泛素蛋白连接酶
RNF126蛋白(39-225AA)
纯化描述 :
蛋白质G纯化
推荐的储存条件 :
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
抗体亚型 :
IgG
基因 :
RNF126
标准基因符号 :
RNF126
反应物种 :
小鼠, 人类
用途 :
酶联免疫吸附测定, IF, 免疫组化, 免疫印迹
ShortWebDescription :
RNF126 antibody LS-C499668 is an unconjugated rabbit polyclonal antibody to RNF126 (aa39-225) from human. It is reactive with human and mouse. Validated for ELISA, IF, IHC and WB.
同义词 :
RNF126, 环指蛋白126
SalesRegion :
Worldwide
更多信息或购买 :
公司信息
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
Seattle, WA 98121
antibodies@lsbio.com
https://www.lsbio.com1-206-464-1554
公司总部: 美国
LifeSpan成立于1995年，已经成为分子病理学领域的领导品牌，专注于人和其他物种的正常和疾病组织中蛋白的定位情况。我们提供超过74000种抗体，定制的免疫组化研究服务，超过500种蛋白研究用人免疫组化材料，及组化和病理学服务；提供2,000,000样本，包括冰冻及石蜡切片的正常和疾病组织，进行对外研究服务。对外服务项目范围广泛，由LifeSpan的病理学家提供包括课题设计、抗体搜寻及表征、组织搜集和验证、免疫标记、问题处理及结果处理等诸多环节。