蛋白

人类PIK3CG/PI3K丙蛋白(重组谷胱甘肽S-转移酶)- LS-G18510

LS-G18510

LS-G18510

人类PIK3CG/PI3K丙蛋白(重组谷胱甘肽S-转移酶)- LS-G18510

The class IA PI3Kd is expressed in endothelial and in white blood cells. Recently it was shown that the inactivation of PI3Kd in bone marrow mast cells (BBMCs) leads to defective stem cell factor-mediated proliferation, adhesion and migration of these cells, and to impaired allergen-IgE induced degranulation and cytokine release. In neutrophils a role for PI3Kd in TNFa-induced signaling was demonstrated by a reduction in Aktphosphorylation and PDK1 activity upon treatment with the d-specific inhibitor IC87114. The catalytic subunit carries a GST-Tag which facilitates the protein's application in typical GST pull-down assays and the heterodimer was purified by affinity chromatography. The molecular weight for p110d chain is 120.2 kDa (without Tag) and the p85a chain 83.5 kDa.

25 mM三羟甲基氨基甲烷氯化氢, pH值8.0, 50 mM氯化钠, 0.5 mM氯化镁, 50% 甘油

谷胱甘肽S-转移酶

重组

人类

Spodoptera frugiperda

Store at 4°C short term. Store at -20°C long term. Carrier protein recommended for long term storage or low concentration. Avoid multiple freeze-thaw cycles

Greater than 95% by SDS PAGE

PIK3CG/PI3K丙

PIK3CG

Non-Protein Kinase

PIK3CG, p110-gamma, p110gamma, PI3-kinase subunit gamma, PI3K, PIK3, p120-PI3K, PI3CG, PI3K-gamma, PI3Kgamma, PtdIns-3-kinase subunit gamma

Worldwide