蛋白

Human MSTN / GDF8 / Myostatin Protein (Recombinant) - LS-G23593

LS-G23593

LS-G23593

Human MSTN / GDF8 / Myostatin Protein (Recombinant) - LS-G23593

Myostatin comes as a dimer having a 109/218 amino acid chain. Myostatin (GDF-8), a conserved member of the TGF-beta superfamily, is an essential regulator of skeletal muscle mass and cardiac muscle development and function. Myostatin is a secreted protein that negatively regulates skeletal muscle growth by determining muscle fiber number and size. Myostatin binds one of the two activin type II receptors (ACTRIIA, ACTRIIB) to activate SMAD signaling. Myostatin also activates MAPK signaling through TAK1-MKK6 and Ras pathways. Inhibition of myostatin increases muscle mass in a number of human disease animal models, such as muscular dystrophy.

Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

重组

人类

大肠杆菌

Store at -20°C to -80°C for up to 1 year. Store at 4°C for up to 1 month or up to 3 months at -20°C to -80°C after reconstitution.

Reconstitute in sterile 20 mM HCl at 0.1 mg/ml

Greater than 95% by SDS-PAGE

24.8 kDa

MSTN / GDF8 / Myostatin

MSTN

TGF乙

MSTN, GDF8, MSLHP, Myostatin, GDF-8

Ambient

Worldwide