产品简要
公司名称 :
MedChem Express LLC
产品类型 :
蛋白
产品名称 :
IL-12 beta, Mouse (HEK293, His)
目录 :
HY-P72597
规格 :
50微克;10微克
价格 :
504;168美元
更多信息或购买 :
产品信息
目录代码 :
HY-P72597
产品名称 :
IL-12 beta, Mouse (HEK293, His)
产品类型 :
蛋白
宿主物种 :
HEK293
规格 :
50微克;10微克
标价 :
504;168美元
背景 :
IL-12 beta Protein, as known as IL12 p4 subunit or IL-12B, heterodimerizes with the IL-12 p35 subunit (IL-12A) to form IL-12 and with the IL23 p19 subunit to form IL-23, exerting different regulating functions [1] .
IL-12 and IL23 belong to IL-12 family, are involved in proinflammatory responses and expressed by activated macrophages that serve as an essential inducer of Th1 cells development [2] .
IL-12 signals via IL-12Rβ1 and IL-12Rβ2 mediated by p-STAT4, whereas IL-23 signals via IL-12Rβ1 and IL-23R mediated by p-STAT1 and p-STAT3 [3] .
The sequence of amino acids in IL-12 beta proteins of mouse is very different from human (69.4%), but shows high similarity with rat (92.24%).
Interleukin 12 (IL-12) family have been known to be inflammatory factors, induce autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis [4] .
纯度 :
>98%
缓冲液 :
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
储存 :
Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
更多信息或购买 :
公司信息
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com609-228-6898
公司总部: 美国