产品简要
公司名称 :
西格玛奥德里奇
其他品牌 :
FLUKA, Sigma-Aldrich, Roche Applied Science
产品类型 :
抗体
产品名称 :
抗毛细血管扩张性共济失调症突变蛋白抗体, 小鼠单克隆
目录 :
A1106
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
MAT3-4G10/8
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
文章摘录数: 37
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠
Atashpaz S, Samadi Shams S, Gonzalez J, Sebestyén E, Arghavanifard N, Gnocchi A, et al. ATR expands embryonic stem cell fate potential in response to replication stress. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 3c
Tan S, Chadha S, Liu Y, Gabasova E, Perera D, Ahmed K, et al. A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability. Cell. 2017;169:1105-1118.e15 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 s6
Franz A, Pirson P, Pilger D, Halder S, Achuthankutty D, Kashkar H, et al. Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun. 2016;7:10612 pubmed 出版商
  • 免疫印迹; 小鼠; 1:3000; 图 3
Rein K, Yanez D, Terré B, Palenzuela L, Aivio S, Wei K, et al. EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele. Nucleic Acids Res. 2015;43:7371-87 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4
Van Sluis M, McStay B. A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage. Genes Dev. 2015;29:1151-63 pubmed 出版商
Shimada M, Tsukada K, Kagawa N, Matsumoto Y. Reprogramming and differentiation-dependent transcriptional alteration of DNA damage response and apoptosis genes in human induced pluripotent stem cells. J Radiat Res. 2019;60:719-728 pubmed 出版商
Sarraf S, Sideris D, Giagtzoglou N, Ni L, Kankel M, Sen A, et al. PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis. Cell Rep. 2019;29:225-235.e5 pubmed 出版商
Pessina F, Giavazzi F, Yin Y, Gioia U, Vitelli V, Galbiati A, et al. Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors. Nat Cell Biol. 2019;21:1286-1299 pubmed 出版商
Velichko A, Petrova N, Luzhin A, Strelkova O, Ovsyannikova N, Kireev I, et al. Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription. Nucleic Acids Res. 2019;: pubmed 出版商
Wu Z, Qiu M, Guo Y, Zhao J, Liu Z, Wang H, et al. OTU deubiquitinase 4 is silenced and radiosensitizes non-small cell lung cancer cells via inhibiting DNA repair. Cancer Cell Int. 2019;19:99 pubmed 出版商
Kari V, Raul S, Henck J, Kitz J, Kramer F, Kosinsky R, et al. The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness. Clin Epigenetics. 2019;11:4 pubmed 出版商
Bhatia V, Valdés Sánchez L, Rodríguez Martínez D, Bhattacharya S. Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice. F1000Res. 2018;7:1233 pubmed 出版商
Baranes Bachar K, Levy Barda A, Oehler J, Reid D, Soria Bretones I, Voss T, et al. The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair. Mol Cell. 2018;69:866-878.e7 pubmed 出版商
Takahashi A, Okada R, Nagao K, Kawamata Y, Hanyu A, Yoshimoto S, et al. Exosomes maintain cellular homeostasis by excreting harmful DNA from cells. Nat Commun. 2017;8:15287 pubmed 出版商
Rossiello F, Aguado J, Sepe S, Iannelli F, Nguyen Q, Pitchiaya S, et al. DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs. Nat Commun. 2017;8:13980 pubmed 出版商
Roohi J, Crowe J, Loredan D, Anyane Yeboa K, Mansukhani M, Omesi L, et al. New diagnosis of atypical ataxia-telangiectasia in a 17-year-old boy with T-cell acute lymphoblastic leukemia and a novel ATM mutation. J Hum Genet. 2017;62:581-584 pubmed 出版商
Sastre Moreno G, Pryor J, Moreno Oñate M, Herrero Ruiz A, Cortés Ledesma F, Blanco L, et al. Regulation of human polλ by ATM-mediated phosphorylation during non-homologous end joining. DNA Repair (Amst). 2017;51:31-45 pubmed 出版商
Moiseeva T, Gamper A, Hood B, Conrads T, Bakkenist C. Human DNA polymerase ? is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19. DNA Repair (Amst). 2016;43:9-17 pubmed 出版商
Beumer J, Fu K, Anyang B, Siegfried J, Bakkenist C. Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma : ATM, ATR and FA in lung carcinoma. BMC Cancer. 2015;15:649 pubmed 出版商
Zhou X, Tolstov Y, Arslan A, Roth W, Grüllich C, Pahernik S, et al. Harnessing the p53-PUMA axis to overcome DNA damage resistance in renal cell carcinoma. Neoplasia. 2014;16:1028-35 pubmed 出版商
Cornell L, Munck J, Alsinet C, Villanueva A, Ogle L, Willoughby C, et al. DNA-PK-A candidate driver of hepatocarcinogenesis and tissue biomarker that predicts response to treatment and survival. Clin Cancer Res. 2015;21:925-33 pubmed 出版商
Valcheva P, Cardus A, Panizo S, Parisi E, Bozic M, Lopez Novoa J, et al. Lack of vitamin D receptor causes stress-induced premature senescence in vascular smooth muscle cells through enhanced local angiotensin-II signals. Atherosclerosis. 2014;235:247-55 pubmed 出版商
Zahn A, Eranki A, Patenaude A, Methot S, Fifield H, Cortizas E, et al. Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination. Proc Natl Acad Sci U S A. 2014;111:E988-97 pubmed 出版商
Sakai H, Fujigaki H, Mazur S, Appella E. Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication. Cell Cycle. 2014;13:1015-29 pubmed 出版商
Gamper A, Rofougaran R, Watkins S, Greenberger J, Beumer J, Bakkenist C. ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage. Nucleic Acids Res. 2013;41:10334-44 pubmed 出版商
Adelman C, Lolo R, Birkbak N, Murina O, Matsuzaki K, Horejsi Z, et al. HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis. Nature. 2013;502:381-4 pubmed 出版商
Wu S, Chen T, Gmeiner W, Chu E, Schmitz J. Development of modified siRNA molecules incorporating 5-fluoro-2'-deoxyuridine residues to enhance cytotoxicity. Nucleic Acids Res. 2013;41:4650-9 pubmed 出版商
Zhang J, De Toledo S, Pandey B, Guo G, Pain D, Li H, et al. Role of the translationally controlled tumor protein in DNA damage sensing and repair. Proc Natl Acad Sci U S A. 2012;109:E926-33 pubmed 出版商
Viana Pereira M, Lee A, Popov S, Bax D, Al Sarraj S, Bridges L, et al. Microsatellite instability in pediatric high grade glioma is associated with genomic profile and differential target gene inactivation. PLoS ONE. 2011;6:e20588 pubmed 出版商
Tavecchio M, Munck J, Cano C, Newell D, Curtin N. Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination. Cancer Chemother Pharmacol. 2012;69:155-64 pubmed 出版商
Munday D, Emmott E, Surtees R, Lardeau C, Wu W, Duprex W, et al. Quantitative proteomic analysis of A549 cells infected with human respiratory syncytial virus. Mol Cell Proteomics. 2010;9:2438-59 pubmed 出版商
Kibe T, Osawa G, Keegan C, de Lange T. Telomere protection by TPP1 is mediated by POT1a and POT1b. Mol Cell Biol. 2010;30:1059-66 pubmed 出版商
Goff J, Shields D, Seki M, Choi S, Epperly M, Dixon T, et al. Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation. Radiat Res. 2009;172:165-74 pubmed 出版商
Delia D, Piane M, Buscemi G, Savio C, Palmeri S, Lulli P, et al. MRE11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangiectasia-like disorder. Hum Mol Genet. 2004;13:2155-63 pubmed
Yang J, Yu Y, Hamrick H, Duerksen Hughes P. ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses. Carcinogenesis. 2003;24:1571-80 pubmed
Burma S, Chen B, Murphy M, Kurimasa A, Chen D. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem. 2001;276:42462-7 pubmed
Spring K, Cross S, Li C, Watters D, Ben Senior L, Waring P, et al. Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype. Cancer Res. 2001;61:4561-8 pubmed
产品信息
Product No. :
A1106
产品名称 :
抗毛细血管扩张性共济失调症突变蛋白抗体, 小鼠单克隆
宿主 :
小鼠
共轭标签 :
未共轭
抗体类型 :
单克隆
Clone Number (if monoclonal) :
MAT3-4G10/8
应用/描述 :
Suitable for immunoprecipitation (IP); western blot: 0.1-0.2 μg/mL using HEK-293T total cel extract; indirect ELISA
物种活性 :
小鼠, 人类
抗体亚型 :
IgG1
浓度 :
~2 mg/毫升
储存 :
存放在-20°C
更多信息或购买 :
公司信息
西格玛奥德里奇
上海市徐汇区淮海中路1010号嘉华中心41楼
techservCN@sial.com
http://www.sigmaaldrich.com/china-mainland.html
800-819-3336 400-620-3333 86-21-6141 5566
公司总部: 美国
Sigma-Aldrich是一家在生命科学领域领先的且拥有高科技产品的公司,致力于为生命科学、制药化工等领域提供高质量的服务和产品。