产品简要
公司名称 :
西格玛奥德里奇
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, FLUKA, Sigma-Aldrich, Novabiochem, Guava, Roche Applied Science
产品类型 :
抗体
产品名称 :
Anti-Actin, α-Smooth Muscle antibody, Mouse monoclonal
目录 :
A5228
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
1A4
反应物种 :
人类, 小鼠, 大鼠, , , , pigs , domestic rabbit
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, reverse phase protein lysate microarray, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 763
出版应用/物种/样本/稀释参考文献
  • 免疫印迹基因敲除验证; 小鼠; 1:1000; 图 s10f
Valussi M, Besser J, Wystub Lis K, Zukunft S, Richter M, Kubin T, et al. Repression of Osmr and Fgfr1 by miR-1/133a prevents cardiomyocyte dedifferentiation and cell cycle entry in the adult heart. Sci Adv. 2021;7:eabi6648 pubmed 出版商
  • 免疫印迹; 大鼠; 图 2b
  • 免疫印迹; 小鼠; 图 5e
Huang H, Liu Q, Zhang T, Zhang J, Zhou J, Jing X, et al. Farnesylthiosalicylic Acid-Loaded Albumin Nanoparticle Alleviates Renal Fibrosis by Inhibiting Ras/Raf1/p38 Signaling Pathway. Int J Nanomedicine. 2021;16:6441-6453 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:100; 图 6c
Srivastava S, Zhou H, Setia O, Dardik A, Fernandez Hernando C, GOODWIN J. Podocyte Glucocorticoid Receptors Are Essential for Glomerular Endothelial Cell Homeostasis in Diabetes Mellitus. J Am Heart Assoc. 2021;10:e019437 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:1000; 图 1a
  • 免疫细胞化学; 人类; 1:1000; 图 7b
Zehender A, Li Y, Lin N, Stefanica A, Nüchel J, Chen C, et al. TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy. Nat Commun. 2021;12:4404 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 s1g
Yoo J, Lee D, Park S, Shin H, Lee K, Kim D, et al. Trophoblast glycoprotein is a marker for efficient sorting of ventral mesencephalic dopaminergic precursors derived from human pluripotent stem cells. NPJ Parkinsons Dis. 2021;7:61 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 2
Zhang Y, Hu M, Yang F, Zhang Y, Ma S, Zhang D, et al. Increased uterine androgen receptor protein abundance results in implantation and mitochondrial defects in pregnant rats with hyperandrogenism and insulin resistance. J Mol Med (Berl). 2021;99:1427-1446 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 s1b
Nam J, Kim A, Choi S, Kim J, Choi K, Cho S, et al. An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage. Nat Commun. 2021;12:3279 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 7b
Palau V, Nugraha B, Benito D, Pascual J, Emmert M, Hoerstrup S, et al. Both Specific Endothelial and Proximal Tubular Adam17 Deletion Protect against Diabetic Nephropathy. Int J Mol Sci. 2021;22: pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 1d
Seol B, Kim Y, Cho Y. Modeling Sialidosis with Neural Precursor Cells Derived from Patient-Derived Induced Pluripotent Stem Cells. Int J Mol Sci. 2021;22: pubmed 出版商
  • 免疫组化; 小鼠; 图 4c
Srivastava S, Zhou H, Setia O, Liu B, Kanasaki K, Koya D, et al. Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy. Nat Commun. 2021;12:2368 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500; 图 5e
Hemanthakumar K, Fang S, Anisimov A, Mäyränpää M, Mervaala E, Kivela R. Cardiovascular disease risk factors induce mesenchymal features and senescence in mouse cardiac endothelial cells. elife. 2021;10: pubmed 出版商
  • 免疫印迹; 大鼠
Yamamoto A, Morioki H, Nakae T, Miyake Y, Harada T, Noda S, et al. Transcription factor old astrocyte specifically induced substance is a novel regulator of kidney fibrosis. FASEB J. 2021;35:e21158 pubmed 出版商
  • 免疫印迹; 人类; 1:5000; 图 3h
Liu Y, Li L, Liu X, Wang Y, Liu L, Peng L, et al. Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling. elife. 2020;9: pubmed 出版商
  • 免疫组化; 人类; 1:200; 图 1b
Bennett R, Hu M, Fernandes A, Pérez Rando M, Robbins A, Kamath T, et al. Tau reduction in aged mice does not impact Microangiopathy. Acta Neuropathol Commun. 2020;8:137 pubmed 出版商
  • 免疫细胞化学; 人类; 1:50; 图 2c
Pseftogas A, Xanthopoulos K, Poutahidis T, Ainali C, Dafou D, Panteris E, et al. The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGF Signaling. Cancers (Basel). 2020;12: pubmed 出版商
  • 免疫细胞化学; 人类; 图 s1d
Hu H, Ji Q, Song M, Ren J, Liu Z, Wang Z, et al. ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin. Nucleic Acids Res. 2020;48:6001-6018 pubmed 出版商
  • 免疫印迹; 人类; 1:24,000; 图 1b
Bozic M, Caus M, Rodrigues Díez R, Pedraza N, Ruiz Ortega M, Garí E, et al. Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis. Nat Commun. 2020;11:1943 pubmed 出版商
  • 免疫细胞化学; 大鼠; 图 s10
  • 免疫印迹; 大鼠; 图 7a
Guo X, Kolpakov M, Hooshdaran B, Schappell W, Wang T, Eguchi S, et al. Cardiac Expression of Factor X Mediates Cardiac Hypertrophy and Fibrosis in Pressure Overload. JACC Basic Transl Sci. 2020;5:69-83 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠; 1:200; 图 5b
  • 免疫细胞化学; 人类; 1:200; 图 2a
Li L, Du Z, Rong B, Zhao D, Wang A, Xu Y, et al. Foam cells promote atherosclerosis progression by releasing CXCL12. Biosci Rep. 2020;40: pubmed 出版商
  • 免疫细胞化学; 人类; 图 1b, 1c
  • 免疫印迹; 人类; 图 s3a
Vijayaraj P, Minasyan A, Durra A, Karumbayaram S, Mehrabi M, Aros C, et al. Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule. Cell Rep. 2019;29:3488-3505.e9 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5b
Welk V, Meul T, Lukas C, Kammerl I, Mulay S, Schamberger A, et al. Proteasome activator PA200 regulates myofibroblast differentiation. Sci Rep. 2019;9:15224 pubmed 出版商
  • 免疫组化-冰冻切片; 鸡; 1:500; 图 2a
Tang W, Martik M, Li Y, Bronner M. Cardiac neural crest contributes to cardiomyocytes in amniotes and heart regeneration in zebrafish. elife. 2019;8: pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 s8c
  • 免疫印迹; 小鼠; 1:1000; 图 7d
  • 免疫组化-石蜡切片; 人类; 1:500; 图 8a
  • 免疫印迹; 人类; 1:500; 图 4d
Rubio K, Singh I, Dobersch S, Sarvari P, Günther S, Cordero J, et al. Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis. Nat Commun. 2019;10:2229 pubmed 出版商
  • 免疫印迹; 人类; 图 6h
Li Y, Hu Q, Li C, Liang K, Xiang Y, Hsiao H, et al. PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease. J Clin Invest. 2019;129:1129-1151 pubmed 出版商
  • 免疫印迹; 人类; 图 s1b
Niu F, Liao K, Hu G, Sil S, Callen S, Guo M, et al. Cocaine-induced release of CXCL10 from pericytes regulates monocyte transmigration into the CNS. J Cell Biol. 2019;218:700-721 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 7e
  • 免疫印迹; 小鼠; 图 1c
  • 免疫印迹; 人类; 图 1a
Liu Z, Li C, Kang N, Malhi H, Shah V, Maiers J. Transforming growth factor β (TGFβ) cross-talk with the unfolded protein response is critical for hepatic stellate cell activation. J Biol Chem. 2019;294:3137-3151 pubmed 出版商
  • 免疫印迹; 人类; 图 1c
Zhang J, Wang D, Wang L, Wang S, Roden A, Zhao H, et al. Profibrotic effect of IL-17A and elevated IL-17RA in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated lung disease support a direct role for IL-17A/IL-17RA in human fibrotic interstitial lung disease. Am J Physiol Lung Cell Mol Physiol. 2019;316:L487-L497 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1b
  • 免疫组化-冰冻切片; 小鼠; 1:200; 图 4a
He S, Nian F, Chen W, Yin L, Auchoybur M, Tao Z, et al. I-κB kinase-ε knockout protects against angiotensin II induced aortic valve thickening in apolipoprotein E deficient mice. Biomed Pharmacother. 2019;109:1287-1295 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:200; 图 3c
Kim A, Lee E, Lee E, Kim J, Suk K, Lee E, et al. SIRT2 is required for efficient reprogramming of mouse embryonic fibroblasts toward pluripotency. Cell Death Dis. 2018;9:893 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500; 图 1b
Karow M, Camp J, Falk S, Gerber T, Pataskar A, Gac Santel M, et al. Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program. Nat Neurosci. 2018;21:932-940 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1i
Zhu F, Zhu Q, Ye D, Zhang Q, Yang Y, Guo X, et al. Sin3a-Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency. Nucleic Acids Res. 2018;46:6026-6040 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 1e
Wen G, An W, Chen J, Maguire E, Chen Q, Yang F, et al. Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Inhibits Experimental Atherosclerosis. J Am Heart Assoc. 2018;7: pubmed 出版商
  • 免疫印迹; 人类; 图 s4b
Niell N, Larriba M, Ferrer Mayorga G, Sanchez Perez I, Cantero R, Real F, et al. The human PKP2/plakophilin-2 gene is induced by Wnt/?-catenin in normal and colon cancer-associated fibroblasts. Int J Cancer. 2018;142:792-804 pubmed 出版商
  • 免疫细胞化学; 人类; 1:400; 图 1j
Alonso Barroso E, Brasil S, Briso Montiano Á, Navarrete R, Perez Cerda C, Ugarte M, et al. Generation and characterization of a human iPSC line from a patient with propionic acidemia due to defects in the PCCA gene. Stem Cell Res. 2017;23:173-177 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:250; 图 1i
Bohnenpoll T, Wittern A, Mamo T, Weiss A, Rudat C, Kleppa M, et al. A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development. PLoS Genet. 2017;13:e1006951 pubmed 出版商
  • 免疫组化; 小鼠; 1:250; 图 5
Mamo T, Wittern A, Kleppa M, Bohnenpoll T, Weiss A, Kispert A. BMP4 uses several different effector pathways to regulate proliferation and differentiation in the epithelial and mesenchymal tissue compartments of the developing mouse ureter. Hum Mol Genet. 2017;26:3553-3563 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:500; 图 3b
  • 免疫印迹; 小鼠; 1:500; 图 3a
Cho H, Kim J, Jang H, Lee T, Jung M, Kim T, et al. Alpha-lipoic acid ameliorates the epithelial mesenchymal transition induced by unilateral ureteral obstruction in mice. Sci Rep. 2017;7:46065 pubmed 出版商
  • 免疫细胞化学; 人类; 图 3b
  • 免疫印迹; 人类; 图 3c
Al Maqtari T, Hong K, Vajravelu B, Moktar A, Cao P, Moore J, et al. Transcription factor-induced activation of cardiac gene expression in human c-kit+ cardiac progenitor cells. PLoS ONE. 2017;12:e0174242 pubmed 出版商
  • 免疫组化; 小鼠; 图 4b
Li N, Xue W, Yuan H, Dong B, Ding Y, Liu Y, et al. AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. J Clin Invest. 2017;127:1284-1302 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 5q
Dahan J, Levillayer F, Xia T, Nouet Y, Werts C, Fanton d Andon M, et al. LIM-Only Protein FHL2 Is a Negative Regulator of Transforming Growth Factor ?1 Expression. Mol Cell Biol. 2017;37: pubmed 出版商
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Xu W, Li B, Guan X, Chung S, Wang Y, Yip Y, et al. Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression. Nat Commun. 2017;8:14399 pubmed 出版商
  • 免疫组化; 小鼠; 1:200; 图 s1
Lim E, Nakanishi S, Hoghooghi V, Eaton S, Palmer A, Frederick A, et al. AlphaB-crystallin regulates remyelination after peripheral nerve injury. Proc Natl Acad Sci U S A. 2017;114:E1707-E1716 pubmed 出版商
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Wu J, Platero Luengo A, Sakurai M, Sugawara A, Gil M, Yamauchi T, et al. Interspecies Chimerism with Mammalian Pluripotent Stem Cells. Cell. 2017;168:473-486.e15 pubmed 出版商
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Tang J, Shen D, Caranasos T, Wang Z, Vandergriff A, Allen T, et al. Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome. Nat Commun. 2017;8:13724 pubmed 出版商
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Hesler R, Huang J, Starr M, Treboschi V, Bernanke A, Nixon A, et al. TGF-?-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3. Carcinogenesis. 2016;37:1041-1051 pubmed 出版商
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Masola V, Zaza G, Gambaro G, Onisto M, Bellin G, Vischini G, et al. Heparanase: A Potential New Factor Involved in the Renal Epithelial Mesenchymal Transition (EMT) Induced by Ischemia/Reperfusion (I/R) Injury. PLoS ONE. 2016;11:e0160074 pubmed 出版商
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Thomsen M, Birkelund S, Burkhart A, Stensballe A, Moos T. Synthesis and deposition of basement membrane proteins by primary brain capillary endothelial cells in a murine model of the blood-brain barrier. J Neurochem. 2017;140:741-754 pubmed 出版商
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Lopez R, Byrne S, Vukcevic M, Sekulic Jablanovic M, Xu L, Brink M, et al. An RYR1 mutation associated with malignant hyperthermia is also associated with bleeding abnormalities. Sci Signal. 2016;9:ra68 pubmed 出版商
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Zaglia T, Di Bona A, Chioato T, Basso C, Ausoni S, Mongillo M. Optimized protocol for immunostaining of experimental GFP-expressing and human hearts. Histochem Cell Biol. 2016;146:407-19 pubmed 出版商
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Zheng X, Xu M, Yao B, Wang C, Jia Y, Liu Q. IL-6/STAT3 axis initiated CAFs via up-regulating TIMP-1 which was attenuated by acetylation of STAT3 induced by PCAF in HCC microenvironment. Cell Signal. 2016;28:1314-24 pubmed 出版商
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Hyslop L, Blakeley P, Craven L, Richardson J, Fogarty N, Fragouli E, et al. Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease. Nature. 2016;534:383-6 pubmed 出版商
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Puchert M, Adams V, Linke A, Engele J. Evidence for the involvement of the CXCL12 system in the adaptation of skeletal muscles to physical exercise. Cell Signal. 2016;28:1205-15 pubmed 出版商
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Kelly J, Esseltine J, Shao Q, Jabs E, SAMPSON J, Auranen M, et al. Specific functional pathologies of Cx43 mutations associated with oculodentodigital dysplasia. Mol Biol Cell. 2016;27:2172-85 pubmed 出版商
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Son M, Lee M, Jeon H, Seol B, Kim J, Chang J, et al. Generation and characterization of integration-free induced pluripotent stem cells from patients with autoimmune disease. Exp Mol Med. 2016;48:e232 pubmed 出版商
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Kwon O, Kim K, Lee E, Kim M, Choi S, Li H, et al. Induction of MiR-21 by Stereotactic Body Radiotherapy Contributes to the Pulmonary Fibrotic Response. PLoS ONE. 2016;11:e0154942 pubmed 出版商
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Miyawaki S, Kawamura Y, Oiwa Y, Shimizu A, Hachiya T, Bono H, et al. Tumour resistance in induced pluripotent stem cells derived from naked mole-rats. Nat Commun. 2016;7:11471 pubmed 出版商
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Choudhary P, Gutteridge A, Impey E, Storer R, Owen R, Whiting P, et al. Targeting the cAMP and Transforming Growth Factor-? Pathway Increases Proliferation to Promote Re-Epithelialization of Human Stem Cell-Derived Retinal Pigment Epithelium. Stem Cells Transl Med. 2016;5:925-37 pubmed 出版商
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Krawiec J, Weinbaum J, Liao H, Ramaswamy A, Pezzone D, Josowitz A, et al. In Vivo Functional Evaluation of Tissue-Engineered Vascular Grafts Fabricated Using Human Adipose-Derived Stem Cells from High Cardiovascular Risk Populations. Tissue Eng Part A. 2016;22:765-75 pubmed 出版商
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Wezel A, De Vries M, Maassen J, Kip P, Peters E, Karper J, et al. Deficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response. Sci Rep. 2016;6:24248 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 1b
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Choi S, Kim M, Lee H, Kim E, Kim C, Lee Y. Effects of NOX1 on fibroblastic changes of endothelial cells in radiation?induced pulmonary fibrosis. Mol Med Rep. 2016;13:4135-42 pubmed 出版商
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Ren J, Li J, Liu X, Feng Y, Gui Y, Yang J, et al. Quercetin Inhibits Fibroblast Activation and Kidney Fibrosis Involving the Suppression of Mammalian Target of Rapamycin and β-catenin Signaling. Sci Rep. 2016;6:23968 pubmed 出版商
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Dey A, Mustafi S, Saha S, Kumar Dhar Dwivedi S, Mukherjee P, Bhattacharya R. Inhibition of BMI1 induces autophagy-mediated necroptosis. Autophagy. 2016;12:659-70 pubmed 出版商
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Meng G, Poon A, Liu S, Rancourt D. An Effective and Reliable Xeno-free Cryopreservation Protocol for Single Human Pluripotent Stem Cells. Methods Mol Biol. 2016;1516:47-56 pubmed 出版商
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Marneros A. Increased VEGF-A promotes multiple distinct aging diseases of the eye through shared pathomechanisms. EMBO Mol Med. 2016;8:208-31 pubmed 出版商
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Fattahi F, Steinbeck J, Kriks S, Tchieu J, Zimmer B, Kishinevsky S, et al. Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease. Nature. 2016;531:105-9 pubmed 出版商
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Jean Charles P, Zhang L, Wu J, Han S, Brian L, Freedman N, et al. Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation. J Biol Chem. 2016;291:7450-64 pubmed 出版商
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Gao Y, Zhao Y, Zhang J, Lu Y, Liu X, Geng P, et al. The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1. Sci Rep. 2016;6:19874 pubmed 出版商
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Avgustinova A, Iravani M, Robertson D, Fearns A, Gao Q, Klingbeil P, et al. Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness. Nat Commun. 2016;7:10305 pubmed 出版商
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Smith K, Zhou B, Avdulov S, Benyumov A, Peterson M, Liu Y, et al. Transforming Growth Factor-β1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E. Sci Rep. 2015;5:18233 pubmed 出版商
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Mallol A, Piqué L, Santaló J, Ibáñez E. Morphokinetics of cloned mouse embryos treated with epigenetic drugs and blastocyst prediction. Reproduction. 2016;151:203-14 pubmed 出版商
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Leclercq A, Veillat V, Loriot S, Spuul P, Madonna F, Roques X, et al. A Methodology for Concomitant Isolation of Intimal and Adventitial Endothelial Cells from the Human Thoracic Aorta. PLoS ONE. 2015;10:e0143144 pubmed 出版商
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Dimitrova N, Gocheva V, Bhutkar A, Resnick R, Jong R, Miller K, et al. Stromal Expression of miR-143/145 Promotes Neoangiogenesis in Lung Cancer Development. Cancer Discov. 2016;6:188-201 pubmed 出版商
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Jung M, Ryu Y, Kang G. Investigation of the origin of stromal and endothelial cells at the desmoplastic interface in xenograft tumor in mice. Pathol Res Pract. 2015;211:925-30 pubmed 出版商
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产品信息
Product No. :
A5228
产品名称 :
Anti-Actin, α-Smooth Muscle antibody, Mouse monoclonal
宿主 :
小鼠
共轭标签 :
未共轭
抗体类型 :
单克隆
Clone Number (if monoclonal) :
1A4
应用/描述 :
Suitable for immunocytochemistry using smooth muscle cells; western blot using smooth muscle cells; microarray; indirect immunofluorescence: 5-10 μg/mL using blood vessels in formalin-fixed, paraffin-embedded human tonsil or appendix tissue
物种活性 :
human, frog, sheep, chicken, goat, bovine, rat, guinea pig, mouse, canine, rabbit, snake
抗体亚型 :
IgG2a
储存 :
存放在-20°C
更多信息或购买 :
公司信息
西格玛奥德里奇
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http://www.sigmaaldrich.com/china-mainland.html
800-819-3336 400-620-3333 86-21-6141 5566
公司总部: 美国
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