产品简要
公司名称 :
西格玛奥德里奇
其他品牌 :
FLUKA, Sigma-Aldrich, Roche Applied Science
产品类型 :
抗体
产品名称 :
抗ATRX在兔生产的抗体
目录 :
HPA001906
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫印迹基因敲除验证, 免疫组化基因敲除验证
更多信息或购买 :
文章摘录数: 61
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 人类; 1:500; 图 1e
Enomoto T, Aoki M, Hamasaki M, Abe H, Nonaka M, Inoue T, et al. Midline Glioma in Adults: Clinicopathological, Genetic, and Epigenetic Analysis. Neurol Med Chir (Tokyo). 2020;60:136-146 pubmed 出版商
  • 免疫印迹; 人类; 1:333; 图 1a
Han M, Napier C, Frölich S, Teber E, Wong T, Noble J, et al. Synthetic lethality of cytolytic HSV-1 in cancer cells with ATRX and PML deficiency. J Cell Sci. 2019;132: pubmed 出版商
  • 免疫组化基因敲除验证; 人类; 1:500; 图 2a
  • 免疫组化; 人类; 图 6a
Brosnan Cashman J, Yuan M, Graham M, Rizzo A, Myers K, Davis C, et al. ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner. PLoS ONE. 2018;13:e0204159 pubmed 出版商
  • 免疫印迹; 人类; 1:400; 图 4c
Diplas B, He X, Brosnan Cashman J, Liu H, Chen L, Wang Z, et al. The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma. Nat Commun. 2018;9:2087 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Deeg K, Chung I, Bauer C, Rippe K. Cancer Cells with Alternative Lengthening of Telomeres Do Not Display a General Hypersensitivity to ATR Inhibition. Front Oncol. 2016;6:186 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 1:1000; 图 4
  • 免疫沉淀; 人类; 图 2
Valle García D, Qadeer Z, McHugh D, Ghiraldini F, Chowdhury A, Hasson D, et al. ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment. Epigenetics. 2016;11:398-414 pubmed 出版商
  • 免疫组化; 人类; 1:500; 图 2
Mäkinen N, Aavikko M, Heikkinen T, Taipale M, Taipale J, Koivisto Korander R, et al. Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12. PLoS Genet. 2016;12:e1005850 pubmed 出版商
Neumann J, Spohn M, Obrecht D, Mynarek M, Thomas C, Hasselblatt M, et al. Molecular characterization of histopathological ependymoma variants. Acta Neuropathol. 2020;139:305-318 pubmed 出版商
Kwon M, Kang S, Cho H, Lee J, Kim S, Suh Y. Clinical relevance of molecular subgrouping of gliomatosis cerebri per 2016 WHO classification: a clinicopathological study of 89 cases. Brain Pathol. 2020;30:235-245 pubmed 出版商
Liang J, Liu H, Li G, Qian J, Gao R, Zhou Y, et al. Global changes in chromatin accessibility and transcription following ATRX inactivation in human cancer cells. FEBS Lett. 2020;594:67-78 pubmed 出版商
Wang L, Li Z, Piao Y, Cai Y, Zhang L, Ge H, et al. Clinico-neuropathological features of isocitrate dehydrogenase 2 gene mutations in lower-grade gliomas. Chin Med J (Engl). 2019;132:2920-2926 pubmed 出版商
Qadeer Z, Valle García D, Hasson D, Sun Z, Cook A, Nguyen C, et al. ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures. Cancer Cell. 2019;36:512-527.e9 pubmed 出版商
Liang J, Zhao H, Diplas B, Liu S, Liu J, Wang D, et al. Genome-wide CRISPR-Cas9 screen reveals selective vulnerability of ATRX-mutant cancers to WEE1 inhibition. Cancer Res. 2019;: pubmed 出版商
Kim G, Rincon Fernandez Pacheco D, Saxon D, Yang A, Sabet S, Dutra Clarke M, et al. Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements. Cell. 2019;179:251-267.e24 pubmed 出版商
Rodriguez F, Graham M, Brosnan Cashman J, Barber J, Davis C, Vizcaíno M, et al. Telomere alterations in neurofibromatosis type 1-associated solid tumors. Acta Neuropathol Commun. 2019;7:139 pubmed 出版商
Burford C, Laxton R, Sidhu Z, Aizpurua M, King A, Bodi I, et al. ATRX immunohistochemistry can help refine 'not elsewhere classified' categorisation for grade II/III gliomas. Br J Neurosurg. 2019;33:536-540 pubmed 出版商
Steele C, Tarabichi M, Oukrif D, Webster A, Ye H, Fittall M, et al. Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways. Cancer Cell. 2019;35:441-456.e8 pubmed 出版商
Yost K, Clatterbuck Soper S, Walker R, Pineda M, Zhu Y, Ester C, et al. Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells. Sci Rep. 2019;9:4544 pubmed 出版商
D Angelo F, Ceccarelli M, Tala -, Garofano L, Zhang J, Frattini V, et al. The molecular landscape of glioma in patients with Neurofibromatosis 1. Nat Med. 2019;25:176-187 pubmed 出版商
Morshed R, Han S, Hervey Jumper S, Pekmezci M, Troncon I, Chang S, et al. Molecular features and clinical outcomes in surgically treated low-grade diffuse gliomas in patients over the age of 60. J Neurooncol. 2019;141:383-391 pubmed 出版商
Vizcaíno M, Palsgrove D, Yuan M, Giannini C, Cabrera Aldana E, Pallavajjala A, et al. Granular cell astrocytoma: an aggressive IDH-wildtype diffuse glioma with molecular genetic features of primary glioblastoma. Brain Pathol. 2019;29:193-204 pubmed 出版商
Rodriguez F, Brosnan Cashman J, Allen S, Vizcaíno M, Giannini C, Camelo Piragua S, et al. Alternative lengthening of telomeres, ATRX loss and H3-K27M mutations in histologically defined pilocytic astrocytoma with anaplasia. Brain Pathol. 2019;29:126-140 pubmed 出版商
Bell W, Meeker A, Rizzo A, Rajpara S, Rosenthal I, Flores Bellver M, et al. A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease. Brain Pathol. 2019;29:45-52 pubmed 出版商
Kafka A, Karin Kujundžić V, Serman L, Bukovac A, Njirić N, Jakovcevic A, et al. Hypermethylation of Secreted Frizzled Related Protein 1 gene promoter in different astrocytoma grades. Croat Med J. 2018;59:213-223 pubmed
Chou A, Itchins M, de Reuver P, Arena J, Clarkson A, Sheen A, et al. ATRX loss is an independent predictor of poor survival in pancreatic neuroendocrine tumors. Hum Pathol. 2018;82:249-257 pubmed 出版商
Bieńkowski M, Wöhrer A, Moser P, Kitzwögerer M, Ricken G, Strobel T, et al. Molecular diagnostic testing of diffuse gliomas in the real-life setting: A practical approach. Clin Neuropathol. 2018;37:166-177 pubmed 出版商
Tauziède Espariat A, Saffroy R, Pages M, Pallud J, Legrand L, Besnard A, et al. Cerebellar high-grade gliomas do not present the same molecular alterations as supratentorial high-grade gliomas and may show histone H3 gene mutations. Clin Neuropathol. 2018;37:209-216 pubmed 出版商
Lu H, Eulo V, Apicelli A, Pekmezci M, Tao Y, Luo J, et al. Aberrant ATRX protein expression is associated with poor overall survival in NF1-MPNST. Oncotarget. 2018;9:23018-23028 pubmed 出版商
Li N, Zhang Y, Sidlauskas K, Ellis M, Evans I, Frankel P, et al. Inhibition of GPR158 by microRNA-449a suppresses neural lineage of glioma stem/progenitor cells and correlates with higher glioma grades. Oncogene. 2018;37:4313-4333 pubmed 出版商
Masui K, Komori T, Kato Y, Masutomi K, Ichimura K, Ogasawara S, et al. Elevated TERT Expression in TERT-Wildtype Adult Diffuse Gliomas: Histological Evaluation with a Novel TERT-Specific Antibody. Biomed Res Int. 2018;2018:7945845 pubmed 出版商
Ueda H, Akiyama Y, Shimada S, Mogushi K, Serizawa M, Matsumura S, et al. Tumor suppressor functions of DAXX through histone H3.3/H3K9me3 pathway in pancreatic NETs. Endocr Relat Cancer. 2018;25:619-631 pubmed 出版商
Ballester L, Boghani Z, Baskin D, Britz G, OLSEN R, Fuller G, et al. Creutzfeldt astrocytes may be seen in IDH-wildtype glioblastoma and retain expression of DNA repair and chromatin binding proteins. Brain Pathol. 2018;28:1012-1019 pubmed 出版商
Kim S, Lee Y, Won J, Park C, Choi S, Park S. Reclassification of Mixed Oligoastrocytic Tumors Using a Genetically Integrated Diagnostic Approach. J Pathol Transl Med. 2018;52:28-36 pubmed 出版商
Panse G, Chrisinger J, Leung C, Ingram D, Khan S, Wani K, et al. Clinicopathological analysis of ATRX, DAXX and NOTCH receptor expression in angiosarcomas. Histopathology. 2018;72:239-247 pubmed 出版商
Fereidouni F, Harmany Z, Tian M, Todd A, Kintner J, McPherson J, et al. Microscopy with ultraviolet surface excitation for rapid slide-free histology. Nat Biomed Eng. 2017;1:957-966 pubmed
Li X, Wei J, Liu Y, Li P, Fan L, Wang Y, et al. Primary Astrocytic Tumours and Paired Recurrences have Similar Biological Features in IDH1, TP53 and TERTp Mutation and MGMT, ATRX Loss. Sci Rep. 2017;7:13038 pubmed 出版商
Bielle F, Di Stefano A, Meyronet D, Picca A, Villa C, Bernier M, et al. Diffuse gliomas with FGFR3-TACC3 fusion have characteristic histopathological and molecular features. Brain Pathol. 2017;: pubmed 出版商
Lee Y, Koh J, Kim S, Won J, Park C, Choi S, et al. The frequency and prognostic effect of TERT promoter mutation in diffuse gliomas. Acta Neuropathol Commun. 2017;5:62 pubmed 出版商
Pratt D, Pittaluga S, Palisoc M, Fetsch P, Xi L, Raffeld M, et al. Expression of CD70 (CD27L) Is Associated With Epithelioid and Sarcomatous Features in IDH-Wild-Type Glioblastoma. J Neuropathol Exp Neurol. 2017;76:697-708 pubmed 出版商
Uekawa K, Nakamura H, Shinojima N, Takezaki T, Yano S, Kuratsu J. Adult Diffuse Astrocytoma in the Medulla Oblongata: Molecular Biological Analyses Including H3F3A Mutation of Histone H3.3. NMC Case Rep J. 2016;3:29-33 pubmed 出版商
Park J, Paik W, Lee K, Ryu J, Lee S, Kim Y. DAXX/ATRX and MEN1 genes are strong prognostic markers in pancreatic neuroendocrine tumors. Oncotarget. 2017;8:49796-49806 pubmed 出版商
Cleven A, Suijker J, Agrogiannis G, Briaire de Bruijn I, Frizzell N, Hoekstra A, et al. IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas. Clin Sarcoma Res. 2017;7:8 pubmed 出版商
Kiviniemi A, Gardberg M, Kivinen K, Posti J, Vuorinen V, Sipila J, et al. Somatostatin receptor 2A in gliomas: Association with oligodendrogliomas and favourable outcome. Oncotarget. 2017;8:49123-49132 pubmed 出版商
Mohamed A, Romano D, Saveanu A, Roche C, Albertelli M, Barbieri F, et al. Anti-proliferative and anti-secretory effects of everolimus on human pancreatic neuroendocrine tumors primary cultures: is there any benefit from combination with somatostatin analogs?. Oncotarget. 2017;8:41044-41063 pubmed 出版商
Vandenbussche C, Allison D, Graham M, Charu V, Lennon A, Wolfgang C, et al. Alternative lengthening of telomeres and ATRX/DAXX loss can be reliably detected in FNAs of pancreatic neuroendocrine tumors. Cancer Cytopathol. 2017;125:544-551 pubmed 出版商
Pekmezci M, Rice T, Molinaro A, Walsh K, Decker P, Hansen H, et al. Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT. Acta Neuropathol. 2017;133:1001-1016 pubmed 出版商
Kim J, Brosnan Cashman J, An S, Kim S, Song K, Kim M, et al. Alternative Lengthening of Telomeres in Primary Pancreatic Neuroendocrine Tumors Is Associated with Aggressive Clinical Behavior and Poor Survival. Clin Cancer Res. 2017;23:1598-1606 pubmed 出版商
Li Y, Shi Z, Aibaidula A, Chen H, Tang Q, Li K, et al. Not all 1p/19q non-codeleted oligodendroglial tumors are astrocytic. Oncotarget. 2016;7:64615-64630 pubmed 出版商
Slatter T, Hsia H, Samaranayaka A, Sykes P, Clow W, Devenish C, et al. Loss of ATRX and DAXX expression identifies poor prognosis for smooth muscle tumours of uncertain malignant potential and early stage uterine leiomyosarcoma. J Pathol Clin Res. 2015;1:95-105 pubmed 出版商
Vinagre J, Nabais J, Pinheiro J, Batista R, Oliveira R, Gonçalves A, et al. TERT promoter mutations in pancreatic endocrine tumours are rare and mainly found in tumours from patients with hereditary syndromes. Sci Rep. 2016;6:29714 pubmed 出版商
Singhi A, Liu T, Roncaioli J, Cao D, Zeh H, Zureikat A, et al. Alternative Lengthening of Telomeres and Loss of DAXX/ATRX Expression Predicts Metastatic Disease and Poor Survival in Patients with Pancreatic Neuroendocrine Tumors. Clin Cancer Res. 2017;23:600-609 pubmed 出版商
Oktay Y, Ãœlgen E, Can Ã, Akyerli C, Yüksel Å, Erdemgil Y, et al. IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation. Sci Rep. 2016;6:27569 pubmed 出版商
Solomon D, Wood M, Tihan T, Bollen A, Gupta N, Phillips J, et al. Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations. Brain Pathol. 2016;26:569-80 pubmed 出版商
Oh J, Ohta T, Nonoguchi N, Satomi K, Capper D, Pierscianek D, et al. Genetic Alterations in Gliosarcoma and Giant Cell Glioblastoma. Brain Pathol. 2016;26:517-22 pubmed 出版商
Yoshida M, Ogawa R, Yoshida H, Maeshima A, Kanai Y, Kinoshita T, et al. TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast. Br J Cancer. 2015;113:1244-8 pubmed 出版商
Koelsche C, Renner M, Johann P, Leiss I, Sahm F, Schimmack S, et al. Differential nuclear ATRX expression in sarcomas. Histopathology. 2016;68:738-45 pubmed 出版商
Napier C, Huschtscha L, Harvey A, Bower K, Noble J, Hendrickson E, et al. ATRX represses alternative lengthening of telomeres. Oncotarget. 2015;6:16543-58 pubmed
Hayashi S, Sasaki H, Kimura T, Abe T, Nakamura T, Kitamura Y, et al. Molecular-genetic and clinical characteristics of gliomas with astrocytic appearance and total 1p19q loss in a single institutional consecutive cohort. Oncotarget. 2015;6:15871-81 pubmed
Reis G, Pekmezci M, Hansen H, Rice T, Marshall R, Molinaro A, et al. CDKN2A loss is associated with shortened overall survival in lower-grade (World Health Organization Grades II-III) astrocytomas. J Neuropathol Exp Neurol. 2015;74:442-52 pubmed 出版商
Fishbein L, Khare S, Wubbenhorst B, Desloover D, D Andrea K, Merrill S, et al. Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas. Nat Commun. 2015;6:6140 pubmed 出版商
Howitt B, Sholl L, Dal Cin P, Jia Y, Yuan L, MacConaill L, et al. Targeted genomic analysis of Müllerian adenosarcoma. J Pathol. 2015;235:37-49 pubmed 出版商
产品信息
Product No. :
HPA001906
产品名称 :
抗ATRX在兔生产的抗体
宿主 :
共轭标签 :
未共轭
抗体类型 :
多克隆
应用/描述 :
Suitable for immunoblotting: 0.04-0.4 μg/mL; immunohistochemistry: 1:500-1:1000; immunofluorescence: 0.25-2 μg/mL
物种活性 :
人类
储存 :
存放在-20°C
更多信息或购买 :
公司信息
西格玛奥德里奇
上海市徐汇区淮海中路1010号嘉华中心41楼
techservCN@sial.com
http://www.sigmaaldrich.com/china-mainland.html
800-819-3336 400-620-3333 86-21-6141 5566
公司总部: 美国
Sigma-Aldrich是一家在生命科学领域领先的且拥有高科技产品的公司,致力于为生命科学、制药化工等领域提供高质量的服务和产品。