产品简要
公司名称 :
西格玛奥德里奇
其他品牌 :
FLUKA, Sigma-Aldrich, Roche Applied Science
产品类型 :
抗体
产品名称 :
抗MCU在兔生产的抗体
目录 :
HPA016480
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
文章摘录数: 65
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 1c
Paggio A, Checchetto V, Campo A, Menabò R, Di Marco G, Di Lisa F, et al. Identification of an ATP-sensitive potassium channel in mitochondria. Nature. 2019;572:609-613 pubmed 出版商
  • 免疫组化; 小鼠; 图 s1a
Wang X, Zhu Y, Long H, Pan S, Xiong H, Fang Q, et al. Mitochondrial Calcium Transporters Mediate Sensitivity to Noise-Induced Losses of Hair Cells and Cochlear Synapses. Front Mol Neurosci. 2018;11:469 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1b
Luongo T, Lambert J, Gross P, Nwokedi M, Lombardi A, Shanmughapriya S, et al. The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability. Nature. 2017;545:93-97 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 1d
  • 免疫沉淀; 小鼠; 图 3a
Tsai C, Wu Y, Pao P, Phillips C, Williams C, Miller C, et al. Proteolytic control of the mitochondrial calcium uniporter complex. Proc Natl Acad Sci U S A. 2017;114:4388-4393 pubmed 出版商
  • 免疫印迹; 人类; 图 1b
Sugiura A, Mattie S, Prudent J, McBride H. Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes. Nature. 2017;542:251-254 pubmed 出版商
  • 免疫印迹; 大鼠; 图 3b
Kim T, Terentyeva R, Roder K, Li W, Liu M, Greener I, et al. SK channel enhancers attenuate Ca2+-dependent arrhythmia in hypertrophic hearts by regulating mito-ROS-dependent oxidation and activity of RyR. Cardiovasc Res. 2017;113:343-353 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1e
Liu J, Liu J, Holmström K, Menazza S, Parks R, Fergusson M, et al. MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload. Cell Rep. 2016;16:1561-1573 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 s2
Vais H, Mallilankaraman K, Mak D, Hoff H, Payne R, Tanis J, et al. EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter. Cell Rep. 2016;14:403-410 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Marland J, Hasel P, Bonnycastle K, Cousin M. Mitochondrial Calcium Uptake Modulates Synaptic Vesicle Endocytosis in Central Nerve Terminals. J Biol Chem. 2016;291:2080-6 pubmed 出版商
Calvo Rodríguez M, Hou S, Snyder A, Kharitonova E, Russ A, Das S, et al. Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease. Nat Commun. 2020;11:2146 pubmed 出版商
Di Marco G, Vallese F, Jourde B, Bergsdorf C, Sturlese M, De Mario A, et al. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020;30:2321-2331.e6 pubmed 出版商
N Belosludtsev K, V Dubinin M, Yu Talanov E, S Starinets V, S Tenkov K, M Zakharova N, et al. Transport of Ca2+ and Ca2+-Dependent Permeability Transition in the Liver and Heart Mitochondria of Rats with Different Tolerance to Acute Hypoxia. Biomolecules. 2020;10: pubmed 出版商
Debattisti V, Horn A, Singh R, Seifert E, Hogarth M, Mazala D, et al. Dysregulation of Mitochondrial Ca2+ Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1. Cell Rep. 2019;29:1274-1286.e6 pubmed 出版商
Norante R, Peggion C, Rossi D, Martorana F, De Mario A, Lia A, et al. ALS-Associated SOD1(G93A) Decreases SERCA Pump Levels and Increases Store-Operated Ca2+ Entry in Primary Spinal Cord Astrocytes from a Transgenic Mouse Model. Int J Mol Sci. 2019;20: pubmed 出版商
Wiersma M, van Marion D, Wüst R, Houtkooper R, Zhang D, Groot N, et al. Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation. Cells. 2019;8: pubmed 出版商
Lombardi A, Gibb A, Arif E, Kolmetzky D, Tomar D, Luongo T, et al. Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation. Nat Commun. 2019;10:4509 pubmed 出版商
Gherardi G, Di Marco G, Rizzuto R, Mammucari C. Crosstalk between Mitochondrial Ca2+ Uptake and Autophagy in Skeletal Muscle. Oxid Med Cell Longev. 2019;2019:1845321 pubmed 出版商
Kowaltowski A, Menezes Filho S, Assali E, Gonçalves I, Cabral Costa J, Abreu P, et al. Mitochondrial morphology regulates organellar Ca2+ uptake and changes cellular Ca2+ homeostasis. FASEB J. 2019;33:13176-13188 pubmed 出版商
Niemann J, Zehm C, Waterstradt R, Tiedge M, Baltrusch S. Cytosolic and mitochondrial Ca2+ concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation. Cell Calcium. 2019;82:102055 pubmed 出版商
Pulli I, Lof C, Blom T, Asghar M, Lassila T, Back N, et al. Sphingosine kinase 1 overexpression induces MFN2 fragmentation and alters mitochondrial matrix Ca2+ handling in HeLa cells. Biochim Biophys Acta Mol Cell Res. 2019;: pubmed 出版商
Carreras Sureda A, Jaña F, Urra H, Durand S, Mortenson D, Sagredo A, et al. Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics. Nat Cell Biol. 2019;: pubmed 出版商
Wang Y, Nguyen N, She J, Zeng W, Yang Y, Bai X, et al. Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter. Cell. 2019;: pubmed 出版商
Bækkerud F, Salerno S, Ceriotti P, Morland C, Storm Mathisen J, Bergersen L, et al. High Intensity Interval Training Ameliorates Mitochondrial Dysfunction in the Left Ventricle of Mice with Type 2 Diabetes. Cardiovasc Toxicol. 2019;: pubmed 出版商
Tomar D, Jaña F, Dong Z, Quinn W, Jadiya P, Breves S, et al. Blockade of MCU-Mediated Ca2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation. Cell Rep. 2019;26:3709-3725.e7 pubmed 出版商
Fedeli C, Filadi R, Rossi A, Mammucari C, Pizzo P. PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis. Autophagy. 2019;15:2044-2062 pubmed 出版商
Wei LaPierre L, Ainbinder A, Tylock K, Dirksen R. Substrate-dependent and cyclophilin D-independent regulation of mitochondrial flashes in skeletal and cardiac muscle. Arch Biochem Biophys. 2019;665:122-131 pubmed 出版商
Miller B, Wang J, Song J, Zhang X, Hirschler Laszkiewicz I, Shanmughapriya S, et al. Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation. J Cell Physiol. 2019;: pubmed 出版商
Liu M, Jeong E, Liu H, Xie A, So E, Shi G, et al. Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function. JCI Insight. 2019;4: pubmed 出版商
Zhao M, Chen J, Mao K, She H, Ren Y, Gui C, et al. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP+ via AMPK pathway. Biochem Biophys Res Commun. 2019;509:390-394 pubmed 出版商
Marchi S, Corricelli M, Branchini A, Vitto V, Missiroli S, Morciano G, et al. Akt-mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth. EMBO J. 2019;38: pubmed 出版商
Chen Q, Tang L, Xin G, Li S, Ma L, Xu Y, et al. Oxidative stress mediated by lipid metabolism contributes to high glucose-induced senescence in retinal pigment epithelium. Free Radic Biol Med. 2019;130:48-58 pubmed 出版商
Roest G, Hesemans E, Welkenhuyzen K, Luyten T, Engedal N, Bultynck G, et al. The ER Stress Inducer l-Azetidine-2-Carboxylic Acid Elevates the Levels of Phospho-eIF2α and of LC3-II in a Ca2+-Dependent Manner. Cells. 2018;7: pubmed 出版商
Wettmarshausen J, Goh V, Huang K, Arduino D, Tripathi U, Leimpek A, et al. MICU1 Confers Protection from MCU-Dependent Manganese Toxicity. Cell Rep. 2018;25:1425-1435.e7 pubmed 出版商
Angebault C, Fauconnier J, Patergnani S, Rieusset J, Danese A, Affortit C, et al. ER-mitochondria cross-talk is regulated by the Ca2+ sensor NCS1 and is impaired in Wolfram syndrome. Sci Signal. 2018;11: pubmed 出版商
Shanmughapriya S, Tomar D, Dong Z, Slovik K, Nemani N, Natarajaseenivasan K, et al. FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation. Nat Commun. 2018;9:3449 pubmed 出版商
Kamer K, Sancak Y, Fomina Y, Meisel J, Chaudhuri D, Grabarek Z, et al. MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2+. Proc Natl Acad Sci U S A. 2018;115:E7960-E7969 pubmed 出版商
Xu H, Guan N, Ren Y, Wei Q, Tao Y, Yang G, et al. IP3R-Grp75-VDAC1-MCU calcium regulation axis antagonists protect podocytes from apoptosis and decrease proteinuria in an Adriamycin nephropathy rat model. BMC Nephrol. 2018;19:140 pubmed 出版商
Yu Z, Chen R, Li M, Yu Y, Liang Y, Han F, et al. Mitochondrial calcium uniporter inhibition provides cardioprotection in pressure overload-induced heart failure through autophagy enhancement. Int J Cardiol. 2018;271:161-168 pubmed 出版商
Xie A, Song Z, Liu H, Zhou A, Shi G, Wang Q, et al. Mitochondrial Ca2+ Influx Contributes to Arrhythmic Risk in Nonischemic Cardiomyopathy. J Am Heart Assoc. 2018;7: pubmed 出版商
Suarez J, Cividini F, Scott B, Lehmann K, Díaz Juárez J, Diemer T, et al. Restoring mitochondrial calcium uniporter expression in diabetic mouse heart improves mitochondrial calcium handling and cardiac function. J Biol Chem. 2018;293:8182-8195 pubmed 出版商
Zeng F, Chen X, Cui W, Wen W, Lu F, Sun X, et al. RIPK1 Binds MCU to Mediate Induction of Mitochondrial Ca2+ Uptake and Promotes Colorectal Oncogenesis. Cancer Res. 2018;78:2876-2885 pubmed 出版商
Pan M, Han Y, Basu A, Dai A, Si R, Willson C, et al. Overexpression of hexokinase 2 reduces mitochondrial calcium overload in coronary endothelial cells of type 2 diabetic mice. Am J Physiol Cell Physiol. 2018;314:C732-C740 pubmed 出版商
Sebag S, Koval O, Paschke J, Winters C, Comellas A, Grumbach I. Inhibition of the mitochondrial calcium uniporter prevents IL-13 and allergen-mediated airway epithelial apoptosis and loss of barrier function. Exp Cell Res. 2018;362:400-411 pubmed 出版商
Chakrabarti R, Ji W, Stan R, de Juan Sanz J, Ryan T, Higgs H. INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division. J Cell Biol. 2018;217:251-268 pubmed 出版商
Yu C, Wang Y, Peng J, Shen Q, Chen M, Tang W, et al. Mitochondrial calcium uniporter as a target of microRNA-340 and promoter of metastasis via enhancing the Warburg effect. Oncotarget. 2017;8:83831-83844 pubmed 出版商
Huang E, Qu D, Huang T, Rizzi N, Boonying W, Krolak D, et al. PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress. Nat Commun. 2017;8:1399 pubmed 出版商
Verma M, Callio J, Otero P, Sekler I, Wills Z, Chu C. Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD/LBD-Associated LRRK2 Mutants. J Neurosci. 2017;37:11151-11165 pubmed 出版商
Hernández Morales M, Sobradillo D, Valero R, Munoz E, Ubierna D, Moyer M, et al. Mitochondria sustain store-operated currents in colon cancer cells but not in normal colonic cells: reversal by non-steroidal anti-inflammatory drugs. Oncotarget. 2017;8:55332-55352 pubmed 出版商
Kiefmann M, Tank S, Keller P, Börnchen C, Rinnenthal J, Tritt M, et al. IDH3 mediates apoptosis of alveolar epithelial cells type 2 due to mitochondrial Ca2+ uptake during hypocapnia. Cell Death Dis. 2017;8:e3005 pubmed 出版商
Arduino D, Wettmarshausen J, Vais H, Navas Navarro P, Cheng Y, Leimpek A, et al. Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening. Mol Cell. 2017;67:711-723.e7 pubmed 出版商
Chen W, Yang J, Chen S, Xiang H, Liu H, Lin D, et al. Importance of mitochondrial calcium uniporter in high glucose-induced endothelial cell dysfunction. Diab Vasc Dis Res. 2017;14:494-501 pubmed 出版商
Kamer K, Grabarek Z, Mootha V. High-affinity cooperative Ca2+ binding by MICU1-MICU2 serves as an on-off switch for the uniporter. EMBO Rep. 2017;18:1397-1411 pubmed 出版商
Cho B, Cho H, Jo Y, Kim H, Song M, Moon C, et al. Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division. Nat Commun. 2017;8:15754 pubmed 出版商
Eshima H, Miura S, Senoo N, Hatakeyama K, Poole D, Kano Y. Improved skeletal muscle Ca2+ regulation in vivo following contractions in mice overexpressing PGC-1α. Am J Physiol Regul Integr Comp Physiol. 2017;312:R1017-R1028 pubmed 出版商
Qiao X, Jia S, Ye J, Fang X, Zhang C, Cao Y, et al. PTPIP51 regulates mouse cardiac ischemia/reperfusion through mediating the mitochondria-SR junction. Sci Rep. 2017;7:45379 pubmed 出版商
Zampieri S, Mammucari C, Romanello V, Barberi L, Pietrangelo L, Fusella A, et al. Physical exercise in aging human skeletal muscle increases mitochondrial calcium uniporter expression levels and affects mitochondria dynamics. Physiol Rep. 2016;4: pubmed 出版商
Naon D, Zaninello M, Giacomello M, Varanita T, Grespi F, Lakshminaranayan S, et al. Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether. Proc Natl Acad Sci U S A. 2016;113:11249-11254 pubmed
de la Fuente S, Fernandez Sanz C, Vail C, Agra E, Holmström K, Sun J, et al. Strategic Positioning and Biased Activity of the Mitochondrial Calcium Uniporter in Cardiac Muscle. J Biol Chem. 2016;291:23343-23362 pubmed
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Zhang J, Wang C, Chen X, Takada M, Fan C, Zheng X, et al. EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer. EMBO J. 2015;34:2953-70 pubmed 出版商
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Quan X, Nguyen T, Choi S, Xu S, Das R, Cha S, et al. Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells. J Biol Chem. 2015;290:4086-96 pubmed 出版商
产品信息
Product No. :
HPA016480
产品名称 :
抗MCU在兔生产的抗体
宿主 :
共轭标签 :
未共轭
抗体类型 :
多克隆
应用/描述 :
Suitable for immunoblotting: 0.04-0.4 μg/mL; immunohistochemistry: 1:50-1:200; immunofluorescence: 0.25-2 μg/mL
物种活性 :
人类
储存 :
存放在-20°C
更多信息或购买 :
公司信息
西格玛奥德里奇
上海市徐汇区淮海中路1010号嘉华中心41楼
techservCN@sial.com
http://www.sigmaaldrich.com/china-mainland.html
800-819-3336 400-620-3333 86-21-6141 5566
公司总部: 美国
Sigma-Aldrich是一家在生命科学领域领先的且拥有高科技产品的公司,致力于为生命科学、制药化工等领域提供高质量的服务和产品。