产品简要
公司名称 :
西格玛奥德里奇
其他品牌 :
FLUKA, Sigma-Aldrich, Roche Applied Science
产品类型 :
抗体
产品名称 :
抗MICU1在兔生产的抗体
目录 :
HPA037480
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 24
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 e1a
Paggio A, Checchetto V, Campo A, Menabò R, Di Marco G, Di Lisa F, et al. Identification of an ATP-sensitive potassium channel in mitochondria. Nature. 2019;572:609-613 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6
Phillips C, Tsai C, Tsai M. The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex. elife. 2019;8: pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 1e
Liu J, Liu J, Holmström K, Menazza S, Parks R, Fergusson M, et al. MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload. Cell Rep. 2016;16:1561-1573 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1:400; 图 1
Antony A, Paillard M, Moffat C, Juskeviciute E, Correnti J, Bolon B, et al. MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration. Nat Commun. 2016;7:10955 pubmed 出版商
  • 免疫印迹; 人类; 1:300; 图 s2
Vais H, Mallilankaraman K, Mak D, Hoff H, Payne R, Tanis J, et al. EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter. Cell Rep. 2016;14:403-410 pubmed 出版商
Calvo Rodríguez M, Hou S, Snyder A, Kharitonova E, Russ A, Das S, et al. Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease. Nat Commun. 2020;11:2146 pubmed 出版商
Di Marco G, Vallese F, Jourde B, Bergsdorf C, Sturlese M, De Mario A, et al. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020;30:2321-2331.e6 pubmed 出版商
Gottschalk B, Klec C, Leitinger G, Bernhart E, Rost R, Bischof H, et al. MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex. Nat Commun. 2019;10:3732 pubmed 出版商
Niemann J, Zehm C, Waterstradt R, Tiedge M, Baltrusch S. Cytosolic and mitochondrial Ca2+ concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation. Cell Calcium. 2019;82:102055 pubmed 出版商
Koval O, Nguyen E, Santhana V, Fidler T, Sebag S, Rasmussen T, et al. Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation. Sci Signal. 2019;12: pubmed 出版商
Tomar D, Jaña F, Dong Z, Quinn W, Jadiya P, Breves S, et al. Blockade of MCU-Mediated Ca2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation. Cell Rep. 2019;26:3709-3725.e7 pubmed 出版商
Xing Y, Wang M, Wang J, Nie Z, Wu G, Yang X, et al. Dimerization of MICU Proteins Controls Ca2+ Influx through the Mitochondrial Ca2+ Uniporter. Cell Rep. 2019;26:1203-1212.e4 pubmed 出版商
Marchi S, Corricelli M, Branchini A, Vitto V, Missiroli S, Morciano G, et al. Akt-mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth. EMBO J. 2019;38: pubmed 出版商
Morra E, Rodrigues P, Jesus I, Do Val Lima P, Ávila R, Zanardo T, et al. Endurance training restores spatially distinct cardiac mitochondrial function and myocardial contractility in ovariectomized rats. Free Radic Biol Med. 2019;130:174-188 pubmed 出版商
Wettmarshausen J, Goh V, Huang K, Arduino D, Tripathi U, Leimpek A, et al. MICU1 Confers Protection from MCU-Dependent Manganese Toxicity. Cell Rep. 2018;25:1425-1435.e7 pubmed 出版商
Kamer K, Sancak Y, Fomina Y, Meisel J, Chaudhuri D, Grabarek Z, et al. MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2+. Proc Natl Acad Sci U S A. 2018;115:E7960-E7969 pubmed 出版商
Suarez J, Cividini F, Scott B, Lehmann K, Díaz Juárez J, Diemer T, et al. Restoring mitochondrial calcium uniporter expression in diabetic mouse heart improves mitochondrial calcium handling and cardiac function. J Biol Chem. 2018;293:8182-8195 pubmed 出版商
Zeng F, Chen X, Cui W, Wen W, Lu F, Sun X, et al. RIPK1 Binds MCU to Mediate Induction of Mitochondrial Ca2+ Uptake and Promotes Colorectal Oncogenesis. Cancer Res. 2018;78:2876-2885 pubmed 出版商
Saita S, Tatsuta T, Lampe P, König T, Ohba Y, Langer T. PARL partitions the lipid transfer protein STARD7 between the cytosol and mitochondria. EMBO J. 2018;37: pubmed 出版商
Verma M, Callio J, Otero P, Sekler I, Wills Z, Chu C. Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD/LBD-Associated LRRK2 Mutants. J Neurosci. 2017;37:11151-11165 pubmed 出版商
Kamer K, Grabarek Z, Mootha V. High-affinity cooperative Ca2+ binding by MICU1-MICU2 serves as an on-off switch for the uniporter. EMBO Rep. 2017;18:1397-1411 pubmed 出版商
Naon D, Zaninello M, Giacomello M, Varanita T, Grespi F, Lakshminaranayan S, et al. Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether. Proc Natl Acad Sci U S A. 2016;113:11249-11254 pubmed
de la Fuente S, Fernandez Sanz C, Vail C, Agra E, Holmström K, Sun J, et al. Strategic Positioning and Biased Activity of the Mitochondrial Calcium Uniporter in Cardiac Muscle. J Biol Chem. 2016;291:23343-23362 pubmed
Lee Y, Min C, Kim T, Song H, Lim Y, Kim D, et al. Structure and function of the N-terminal domain of the human mitochondrial calcium uniporter. EMBO Rep. 2015;16:1318-33 pubmed 出版商
产品信息
Product No. :
HPA037480
产品名称 :
抗MICU1在兔生产的抗体
宿主 :
共轭标签 :
未共轭
抗体类型 :
多克隆
应用/描述 :
Suitable for immunohistochemistry: 1:50-1:200; western blot: 0.04-0.4 μg/mL
物种活性 :
人类
储存 :
存放在-20°C
更多信息或购买 :
公司信息
西格玛奥德里奇
上海市徐汇区淮海中路1010号嘉华中心41楼
techservCN@sial.com
http://www.sigmaaldrich.com/china-mainland.html
800-819-3336 400-620-3333 86-21-6141 5566
公司总部: 美国
Sigma-Aldrich是一家在生命科学领域领先的且拥有高科技产品的公司,致力于为生命科学、制药化工等领域提供高质量的服务和产品。