Gualtieri A, Kyprianou N, Gregory L, Vignola M, Nicholson J, Tan R, et al. Activating mutations in BRAF disrupt the hypothalamo-pituitary axis leading to hypopituitarism in mice and humans. Nat Commun. 2021;12:2028 pubmed 出版商

Gao Q, Ouyang W, Kang B, Han X, Xiong Y, Ding R, et al. Selective targeting of the oncogenic KRAS G12S mutant allele by CRISPR/Cas9 induces efficient tumor regression. Theranostics. 2020;10:5137-5153 pubmed 出版商

Haag A, Walser M, Henggeler A, Hajnal A. The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells. elife. 2020;9: pubmed 出版商

Kennedy S, Jarboui M, Srihari S, Raso C, Bryan K, Dernayka L, et al. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. Nat Commun. 2020;11:499 pubmed 出版商

Fossati G, Pozzi D, Canzi A, Mirabella F, Valentino S, Morini R, et al. Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin. EMBO J. 2019;38: pubmed 出版商

De Pasquale V, Pezone A, Sarogni P, Tramontano A, Schiattarella G, Avvedimento V, et al. EGFR activation triggers cellular hypertrophy and lysosomal disease in NAGLU-depleted cardiomyoblasts, mimicking the hallmarks of mucopolysaccharidosis IIIB. Cell Death Dis. 2018;9:40 pubmed 出版商

Bostner J, Alayev A, Berman A, Fornander T, Nordenskjold B, Holz M, et al. Raptor localization predicts prognosis and tamoxifen response in estrogen receptor-positive breast cancer. Breast Cancer Res Treat. 2018;168:17-27 pubmed 出版商

Zhao F, Franco H, Rodriguez K, Brown P, Tsai M, Tsai S, et al. Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice. Science. 2017;357:717-720 pubmed 出版商

Olivares O, Mayers J, Gouirand V, Torrence M, Gicquel T, Borge L, et al. Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions. Nat Commun. 2017;8:16031 pubmed 出版商

Szoka L, Karna E, Hlebowicz Sarat K, Karaszewski J, Palka J. Exogenous proline stimulates type I collagen and HIF-1? expression and the process is attenuated by glutamine in human skin fibroblasts. Mol Cell Biochem. 2017;435:197-206 pubmed 出版商

Kozlovskaja GumbrienÄ— A, Yi R, Alexander R, Aman A, Jiskra R, Nagelberg D, et al. Proliferation-independent regulation of organ size by Fgf/Notch signaling. elife. 2017;6: pubmed 出版商

Lopes M, Leal R, Guarnieri R, Schwarzbold M, Hoeller A, Diaz A, et al. A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system. Transl Psychiatry. 2016;6:e986 pubmed 出版商

Bangi E, Murgia C, Teague A, Sansom O, Cagan R. Functional exploration of colorectal cancer genomes using Drosophila. Nat Commun. 2016;7:13615 pubmed 出版商

Alekhina O, Marchese A. ?-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4. J Biol Chem. 2016;291:26083-26097 pubmed

Greenwood E, Maisel S, Ebertz D, Russ A, Pandey R, SCHROEDER J. Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration. Oncotarget. 2016;7:60776-60792 pubmed 出版商

Tadjuidje E, Kofron M, Mir A, Wylie C, Heasman J, Cha S. Nodal signalling in Xenopus: the role of Xnr5 in left/right asymmetry and heart development. Open Biol. 2016;6: pubmed 出版商

Schütz I, López Hernández T, Gao Q, Puchkov D, Jabs S, Nordmeyer D, et al. Lysosomal Dysfunction Caused by Cellular Accumulation of Silica Nanoparticles. J Biol Chem. 2016;291:14170-84 pubmed 出版商

Mendel I, Yacov N, Shoham A, Ishai E, Breitbart E. Treatment with Oxidized Phospholipids Directly Inhibits Nonalcoholic Steatohepatitis and Liver Fibrosis Without Affecting Steatosis. Dig Dis Sci. 2016;61:2545-53 pubmed 出版商

Sakakini N, Turchi L, Bergon A, Holota H, Rekima S, Lopez F, et al. A Positive Feed-forward Loop Associating EGR1 and PDGFA Promotes Proliferation and Self-renewal in Glioblastoma Stem Cells. J Biol Chem. 2016;291:10684-99 pubmed 出版商

Morena D, Maestro N, Bersani F, Forni P, Lingua M, Foglizzo V, et al. Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes. elife. 2016;5: pubmed 出版商

Stefanovic M, Tutusaus A, Martinez Nieto G, Bárcena C, de Gregorio E, Moutinho C, et al. Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma. Oncotarget. 2016;7:8253-67 pubmed 出版商

Shukla P, Vogl C, Wallner B, Rigler D, Müller M, Macho Maschler S. High-throughput mRNA and miRNA profiling of epithelial-mesenchymal transition in MDCK cells. BMC Genomics. 2015;16:944 pubmed 出版商

Sun D, Buttitta L. Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila. Development. 2015;142:3033-45 pubmed 出版商

Patel P, Dutta D, Edgar B. Niche appropriation by Drosophila intestinal stem cell tumours. Nat Cell Biol. 2015;17:1182-92 pubmed 出版商

Brohée L, Demine S, Willems J, Arnould T, Colige A, Deroanne C. Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment. Oncotarget. 2015;6:11264-80 pubmed

Wilson F, Johannessen C, Piccioni F, Tamayo P, Kim J, Van Allen E, et al. A functional landscape of resistance to ALK inhibition in lung cancer. Cancer Cell. 2015;27:397-408 pubmed 出版商

Guillaumond F, Bidaut G, Ouaissi M, Servais S, Gouirand V, Olivares O, et al. Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma. Proc Natl Acad Sci U S A. 2015;112:2473-8 pubmed 出版商

Diesenberg K, Beerbaum M, Fink U, Schmieder P, Krauss M. SEPT9 negatively regulates ubiquitin-dependent downregulation of EGFR. J Cell Sci. 2015;128:397-407 pubmed 出版商

Matsuoka S, Gupta S, Suzuki E, Hiromi Y, Asaoka M. gone early, a novel germline factor, ensures the proper size of the stem cell precursor pool in the Drosophila ovary. PLoS ONE. 2014;9:e113423 pubmed 出版商

Charlaftis N, Suddason T, Wu X, Anwar S, Karin M, Gallagher E. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. EMBO J. 2014;33:2581-96 pubmed 出版商

Zeldich E, Chen C, Colvin T, Bove Fenderson E, Liang J, Tucker Zhou T, et al. The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem. 2014;289:24700-15 pubmed 出版商

Martínez Pinilla E, Reyes Resina I, Oñatibia Astibia A, Zamarbide M, Ricobaraza A, Navarro G, et al. CB1 and GPR55 receptors are co-expressed and form heteromers in rat and monkey striatum. Exp Neurol. 2014;261:44-52 pubmed 出版商

Chen P, Qin L, Zhuang Z, Tellides G, Lax I, Schlessinger J, et al. The docking protein FRS2? is a critical regulator of VEGF receptors signaling. Proc Natl Acad Sci U S A. 2014;111:5514-9 pubmed 出版商

Guerra M, Wauson E, McGlynn K, Cobb M. Muscarinic control of MIN6 pancreatic ? cells is enhanced by impaired amino acid signaling. J Biol Chem. 2014;289:14370-9 pubmed 出版商

Bölck B, Ibrahim M, Steinritz D, Morguet C, Dühr S, Suhr F, et al. Detection of key enzymes, free radical reaction products and activated signaling molecules as biomarkers of cell damage induced by benzo[a]pyrene in human keratinocytes. Toxicol In Vitro. 2014;28:875-84 pubmed 出版商

Fernandez Estevez M, Casarejos M, Lopez Sendon J, Garcia Caldentey J, Ruiz C, Gomez A, et al. Trehalose reverses cell malfunction in fibroblasts from normal and Huntington's disease patients caused by proteosome inhibition. PLoS ONE. 2014;9:e90202 pubmed 出版商

Turner M, Cronin J, Healey G, Sheldon I. Epithelial and stromal cells of bovine endometrium have roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides in vitro via Toll-like receptors TLR2, TLR1, and TLR6. Endocrinology. 2014;155:1453-65 pubmed 出版商

Zaganjor E, Osborne J, Weil L, Díaz Martínez L, Gonzales J, Singel S, et al. Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells. Oncogene. 2014;33:5457-66 pubmed 出版商

Kaur H, Sharma S, Mandal S, Mandal L. Lar maintains the homeostasis of the hematopoietic organ in Drosophila by regulating insulin signaling in the niche. Development. 2019;146: pubmed 出版商

He Q, Shumate L, Matthias J, Aydin C, Wein M, Spatz J, et al. A G protein-coupled, IP3/protein kinase C pathway controlling the synthesis of phosphaturic hormone FGF23. JCI Insight. 2019;4: pubmed 出版商

Wallroth A, Koch P, Marat A, Krause E, Haucke V. Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1. Nat Cell Biol. 2019;21:1093-1101 pubmed 出版商

Kondo T, Hayashi S. Two-step regulation of trachealess ensures tight coupling of cell fate with morphogenesis in the Drosophila trachea. elife. 2019;8: pubmed 出版商

Zingkou E, Pampalakis G, Charla E, Nauroy P, Kiritsi D, Sotiropoulou G. A proinflammatory role of KLK6 protease in Netherton syndrome. J Dermatol Sci. 2019;95:28-35 pubmed 出版商

Ning S, Wang Z, Cao J, Dong Y, Chen Y. Mel1c Mediated Monochromatic Light-Stimulated IGF-I Synthesis through the Intracellular Gαq/PKC/ERK Signaling Pathway. Int J Mol Sci. 2019;20: pubmed 出版商

Stundl J, Pospisilova A, Jandzik D, Fabian P, Dobiášová B, Minarik M, et al. Bichir external gills arise via heterochronic shift that accelerates hyoid arch development. elife. 2019;8: pubmed 出版商

Achache H, Laurent L, Hecker Mimoun Y, Ishtayeh H, Rappaport Y, Kroizer E, et al. Progression of Meiosis Is Coordinated by the Level and Location of MAPK Activation Via OGR-2 in Caenorhabditis elegans. Genetics. 2019;212:213-229 pubmed 出版商

Ishay Ronen D, Diepenbruck M, Kalathur R, Sugiyama N, Tiede S, Ivanek R, et al. Gain Fat-Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis. Cancer Cell. 2019;35:17-32.e6 pubmed 出版商

Packer L, Stehbens S, Bonazzi V, Gunter J, Ju R, Ward M, et al. Bcl-2 inhibitors enhance FGFR inhibitor-induced mitochondrial-dependent cell death in FGFR2-mutant endometrial cancer. Mol Oncol. 2019;13:738-756 pubmed 出版商

Golderman V, Shavit Stein E, Gera O, Chapman J, Eisenkraft A, Maggio N. Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus. J Mol Neurosci. 2019;67:227-234 pubmed 出版商

Colle D, Santos D, de Souza V, Lopes M, Leal R, de Souza Brocardo P, et al. Sodium selenite protects from 3-nitropropionic acid-induced oxidative stress in cultured primary cortical neurons. Mol Biol Rep. 2019;46:751-762 pubmed 出版商

Wang A, Hirose T, Ohsaki Y, Takahashi C, Sato E, Oba Yabana I, et al. Hydrochlorothiazide ameliorates polyuria caused by tolvaptan treatment of polycystic kidney disease in PCK rats. Clin Exp Nephrol. 2019;23:455-464 pubmed 出版商

Beaudry K, Langlois M, Montagne A, Cagnol S, Carrier J, Rivard N. Dual-specificity phosphatase 6 deletion protects the colonic epithelium against inflammation and promotes both proliferation and tumorigenesis. J Cell Physiol. 2019;234:6731-6745 pubmed 出版商

Arbel Rubinstein T, Shahmoon S, Zigmond E, Etan T, Merenbakh Lamin K, Pasmanik Chor M, et al. Klotho suppresses colorectal cancer through modulation of the unfolded protein response. Oncogene. 2019;38:794-807 pubmed 出版商

Shavit Stein E, Sheinberg E, Golderman V, Sharabi S, Wohl A, Gofrit S, et al. A Novel Compound Targeting Protease Receptor 1 Activators for the Treatment of Glioblastoma. Front Neurol. 2018;9:1087 pubmed 出版商

Wong K, Akiyama R, Bessho Y, Matsui T. ERK Activity Dynamics during Zebrafish Embryonic Development. Int J Mol Sci. 2018;20: pubmed 出版商

Zheng S, Qu Z, Zanetti M, Lam B, Chin Sang I. C. elegans PTEN and AMPK block neuroblast divisions by inhibiting a BMP-insulin-PP2A-MAPK pathway. Development. 2018;145: pubmed 出版商

Boulter E, Estrach S, Tissot F, Hennrich M, Tosello L, Cailleteau L, et al. Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway. Nat Commun. 2018;9:4862 pubmed 出版商

Zoranovic T, Manent J, Willoughby L, Matos de Simoes R, La Marca J, Golenkina S, et al. A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer. PLoS Genet. 2018;14:e1007688 pubmed 出版商

Courgeon M, He D, Liu H, Legent K, Treisman J. The Drosophila Epidermal Growth Factor Receptor does not act in the nucleus. J Cell Sci. 2018;131: pubmed 出版商

Taylor E, Heyland A. Thyroid Hormones Accelerate Initiation of Skeletogenesis via MAPK (ERK1/2) in Larval Sea Urchins (Strongylocentrotus purpuratus). Front Endocrinol (Lausanne). 2018;9:439 pubmed 出版商

Raiders S, Eastwood M, Bacher M, Priess J. Binucleate germ cells in Caenorhabditis elegans are removed by physiological apoptosis. PLoS Genet. 2018;14:e1007417 pubmed 出版商

Saydmohammed M, Vollmer L, Onuoha E, Maskrey T, Gibson G, Watkins S, et al. A High-Content Screen Reveals New Small-Molecule Enhancers of Ras/Mapk Signaling as Probes for Zebrafish Heart Development. Molecules. 2018;23: pubmed 出版商

Simsek M, Ozbudak E. Spatial Fold Change of FGF Signaling Encodes Positional Information for Segmental Determination in Zebrafish. Cell Rep. 2018;24:66-78.e8 pubmed 出版商

De Pasquale V, Sarogni P, Pistorio V, Cerulo G, Paladino S, Pavone L. Targeting Heparan Sulfate Proteoglycans as a Novel Therapeutic Strategy for Mucopolysaccharidoses. Mol Ther Methods Clin Dev. 2018;10:8-16 pubmed 出版商

English E, Mahn S, Marchese A. Endocytosis is required for CXC chemokine receptor type 4 (CXCR4)-mediated Akt activation and antiapoptotic signaling. J Biol Chem. 2018;293:11470-11480 pubmed 出版商

Zahavi E, Steinberg N, Altman T, Chein M, Joshi Y, Gradus Pery T, et al. The receptor tyrosine kinase TrkB signals without dimerization at the plasma membrane. Sci Signal. 2018;11: pubmed 出版商

Shiloh R, Gilad Y, Ber Y, Eisenstein M, Aweida D, Bialik S, et al. Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy. Nat Commun. 2018;9:1759 pubmed 出版商

Majorini M, Manenti G, Mano M, De Cecco L, Conti A, Pinciroli P, et al. cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells. Cell Death Differ. 2018;25:2147-2164 pubmed 出版商

Loch C, Haeger J, Pfarrer C. IFNτ mediates chemotaxis, motility, metabolism and CK18 downregulation in bovine trophoblast cells in vitro via STAT1 and MAPK42/44 signaling. Placenta. 2018;64:17-26 pubmed 出版商

Andriani F, Majorini M, Mano M, Landoni E, Miceli R, Facchinetti F, et al. MiR-16 regulates the pro-tumorigenic potential of lung fibroblasts through the inhibition of HGF production in an FGFR-1- and MEK1-dependent manner. J Hematol Oncol. 2018;11:45 pubmed 出版商

Ferrer C, Alders M, Postma A, Park S, Klein M, Cetinbaş M, et al. An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality. Genes Dev. 2018;32:373-388 pubmed 出版商

Yamamoto Fukuda T, Akiyama N, Takahashi M, Kojima H. Keratinocyte Growth Factor (KGF) Modulates Epidermal Progenitor Cell Kinetics through Activation of p63 in Middle Ear Cholesteatoma. J Assoc Res Otolaryngol. 2018;19:223-241 pubmed 出版商

Miskolczi Z, Smith M, Rowling E, Ferguson J, Barriuso J, Wellbrock C. Collagen abundance controls melanoma phenotypes through lineage-specific microenvironment sensing. Oncogene. 2018;37:3166-3182 pubmed 出版商

Sari D, Akiyama R, Naoki H, Ishijima H, Bessho Y, Matsui T. Time-lapse observation of stepwise regression of Erk activity in zebrafish presomitic mesoderm. Sci Rep. 2018;8:4335 pubmed 出版商

van IJzendoorn D, Sleijfer S, Gelderblom H, Eskens F, van Leenders G, Szuhai K, et al. Telatinib Is an Effective Targeted Therapy for Pseudomyogenic Hemangioendothelioma. Clin Cancer Res. 2018;24:2678-2687 pubmed 出版商

Maisel S, Broka D, SCHROEDER J. Intravesicular epidermal growth factor receptor subject to retrograde trafficking drives epidermal growth factor-dependent migration. Oncotarget. 2018;9:6463-6477 pubmed 出版商

Missinato M, Saydmohammed M, Zuppo D, Rao K, Opie G, Kuhn B, et al. Dusp6 attenuates Ras/MAPK signaling to limit zebrafish heart regeneration. Development. 2018;145: pubmed 出版商

Danziger O, Pupko T, Bacharach E, Ehrlich M. Interleukin-6 and Interferon-α Signaling via JAK1-STAT Differentially Regulate Oncolytic versus Cytoprotective Antiviral States. Front Immunol. 2018;9:94 pubmed 出版商

Ando T, Fujiwara H, Kojima T. The pivotal role of aristaless in development and evolution of diverse antennal morphologies in moths and butterflies. BMC Evol Biol. 2018;18:8 pubmed 出版商

Van Boxtel A, Economou A, Heliot C, Hill C. Long-Range Signaling Activation and Local Inhibition Separate the Mesoderm and Endoderm Lineages. Dev Cell. 2018;44:179-191.e5 pubmed 出版商

Završnik J, Butinar M, Prebanda M, Krajnc A, Vidmar R, Fonovic M, et al. Cystatin C deficiency suppresses tumor growth in a breast cancer model through decreased proliferation of tumor cells. Oncotarget. 2017;8:73793-73809 pubmed 出版商

Wolfstetter G, Pfeifer K, van Dijk J, Hugosson F, Lu X, Palmer R. The scaffolding protein Cnk binds to the receptor tyrosine kinase Alk to promote visceral founder cell specification in Drosophila. Sci Signal. 2017;10: pubmed 出版商

Zhao J, Zhao J, Xu G, Wang Z, Gao J, Cui S, et al. Deletion of Spata2 by CRISPR/Cas9n causes increased inhibin alpha expression and attenuated fertility in male mice. Biol Reprod. 2017;97:497-513 pubmed 出版商

Kirsch N, Chang L, Koch S, Glinka A, Dolde C, Colozza G, et al. Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover. Dev Cell. 2017;43:71-82.e6 pubmed 出版商

Neiswender J, Kortum R, Bourque C, Kasheta M, Zon L, Morrison D, et al. KIT Suppresses BRAFV600E-Mutant Melanoma by Attenuating Oncogenic RAS/MAPK Signaling. Cancer Res. 2017;77:5820-5830 pubmed 出版商

Cao J, Heijkants R, Jochemsen A, Dogrusöz M, de Lange M, van der Velden P, et al. Targeting of the MAPK and AKT pathways in conjunctival melanoma shows potential synergy. Oncotarget. 2017;8:58021-58036 pubmed 出版商

Szoka L, Karna E, Hlebowicz Sarat K, Karaszewski J, Boryczka S, Palka J. Acetylenic derivative of betulin induces apoptosis in endometrial adenocarcinoma cell line. Biomed Pharmacother. 2017;95:429-436 pubmed 出版商

Yoon D, Alfhili M, Friend K, Lee M. MPK-1/ERK regulatory network controls the number of sperm by regulating timing of sperm-oocyte switch in C. elegans germline. Biochem Biophys Res Commun. 2017;491:1077-1082 pubmed 出版商

Glennon E, Torrevillas B, Morrissey S, Ejercito J, Luckhart S. Abscisic acid induces a transient shift in signaling that enhances NF-κB-mediated parasite killing in the midgut of Anopheles stephensi without reducing lifespan or fecundity. Parasit Vectors. 2017;10:333 pubmed 出版商

Yoon S, Kovalenko A, Bogdanov K, Wallach D. MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation. Immunity. 2017;47:51-65.e7 pubmed 出版商

Gamage T, Anderson J, Abood M. CB1 allosteric modulator Org27569 is an antagonist/inverse agonist of ERK1/2 signaling. Cannabis Cannabinoid Res. 2016;1:272-280 pubmed 出版商

Suisse A, He D, Legent K, Treisman J. COP9 signalosome subunits protect Capicua from MAPK-dependent and -independent mechanisms of degradation. Development. 2017;144:2673-2682 pubmed 出版商

Rives Quinto N, Franco M, de Torres Jurado A, Carmena A. Synergism between canoe and scribble mutations causes tumor-like overgrowth via Ras activation in neural stem cells and epithelia. Development. 2017;144:2570-2583 pubmed 出版商

Liu W, Cvekl A. Six3 in a small population of progenitors at E8.5 is required for neuroretinal specification via regulating cell signaling and survival in mice. Dev Biol. 2017;428:164-175 pubmed 出版商

Kugita M, Nishii K, Yamaguchi T, Suzuki A, Yuzawa Y, Horie S, et al. Beneficial effect of combined treatment with octreotide and pasireotide in PCK rats, an orthologous model of human autosomal recessive polycystic kidney disease. PLoS ONE. 2017;12:e0177934 pubmed 出版商

Sala V, Gallo S, Gatti S, Vigna E, Ponzetto A, Crepaldi T. Anti-Differentiation Effect of Oncogenic Met Receptor in Terminally-Differentiated Myotubes. Biomedicines. 2015;3:124-137 pubmed 出版商

Dorard C, Estrada C, Barbotin C, Larcher M, Garancher A, Leloup J, et al. RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma. Nat Commun. 2017;8:15262 pubmed 出版商

Budai M, Tozser J, Benko S. Different dynamics of NLRP3 inflammasome-mediated IL?1? production in GM-CSF- and M-CSF-differentiated human macrophages. J Leukoc Biol. 2017;101:1335-1347 pubmed 出版商

Guerra M, Kalwat M, McGlynn K, Cobb M. Sucralose activates an ERK1/2-ribosomal protein S6 signaling axis. FEBS Open Bio. 2017;7:174-186 pubmed 出版商

Schmukler E, Wolfson E, Elazar Z, Kloog Y, Pinkas Kramarski R. Continuous treatment with FTS confers resistance to apoptosis and affects autophagy. PLoS ONE. 2017;12:e0171351 pubmed 出版商

Mendel I, Yacov N, Salem Y, Propheta Meiran O, Ishai E, Breitbart E. Identification of Motile Sperm Domain-Containing Protein 2 as Regulator of Human Monocyte Migration. J Immunol. 2017;198:2125-2132 pubmed 出版商

Kidger A, Rushworth L, Stellzig J, Davidson J, Bryant C, Bayley C, et al. Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling. Proc Natl Acad Sci U S A. 2017;114:E317-E326 pubmed 出版商

Steinhauer J. Co-culture Activation of MAP Kinase in Drosophila S2 Cells. Methods Mol Biol. 2017;1487:235-241 pubmed

Rieger D, Navarro E, Buendia I, Parada E, González Lafuente L, Leon R, et al. ConBr, A Lectin Purified from the Seeds of Canavalia brasiliensis, Protects Against Ischemia in Organotypic Culture of Rat Hippocampus: Potential Implication of Voltage-Gated Calcium Channels. Neurochem Res. 2017;42:347-359 pubmed 出版商

Hoffmann H, Crouzin N, Moreno E, Raivio N, Fuentes S, McCormick P, et al. Long-Lasting Impairment of mGluR5-Activated Intracellular Pathways in the Striatum After Withdrawal of Cocaine Self-Administration. Int J Neuropsychopharmacol. 2017;20:72-82 pubmed 出版商

Levinson S, Cagan R. Drosophila Cancer Models Identify Functional Differences between Ret Fusions. Cell Rep. 2016;16:3052-3061 pubmed 出版商

Peterse E, Cleven A, de Jong Y, Briaire de Bruijn I, Fletcher J, Danen E, et al. No preclinical rationale for IGF1R directed therapy in chondrosarcoma of bone. BMC Cancer. 2016;16:475 pubmed 出版商

Filippi S, Barnes C, Kirk P, Kudo T, Kunida K, McMahon S, et al. Robustness of MEK-ERK Dynamics and Origins of Cell-to-Cell Variability in MAPK Signaling. Cell Rep. 2016;15:2524-35 pubmed 出版商

Jin M, Eblimit A, Pulikkathara M, Corr S, Chen R, Mardon G. Conditional knockout of retinal determination genes in differentiating cells in Drosophila. FEBS J. 2016;283:2754-66 pubmed 出版商

PETRUCCELLI E, Li Q, Rao Y, Kitamoto T. The Unique Dopamine/Ecdysteroid Receptor Modulates Ethanol-Induced Sedation in Drosophila. J Neurosci. 2016;36:4647-57 pubmed 出版商

Ferenczi E, Vierock J, Atsuta Tsunoda K, Tsunoda S, Ramakrishnan C, Gorini C, et al. Optogenetic approaches addressing extracellular modulation of neural excitability. Sci Rep. 2016;6:23947 pubmed 出版商

Waizenegger I, Baum A, Steurer S, Stadtmüller H, Bader G, Schaaf O, et al. A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation. Mol Cancer Ther. 2016;15:354-65 pubmed 出版商

Bhargava A, Anant M, Mack H. Registered report: Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. elife. 2016;5: pubmed 出版商

Winter A, Sigurdardottir A, DiCara D, Valenti G, Blundell T, Gherardi E. Developing Antagonists for the Met-HGF/SF Protein-Protein Interaction Using a Fragment-Based Approach. Mol Cancer Ther. 2016;15:3-14 pubmed 出版商

Keravis T, Favot L, Abusnina A, Anton A, Justiniano H, Soleti R, et al. Delphinidin Inhibits Tumor Growth by Acting on VEGF Signalling in Endothelial Cells. PLoS ONE. 2015;10:e0145291 pubmed 出版商

Mattingly H, Chen J, Arur S, Shvartsman S. A Transport Model for Estimating the Time Course of ERK Activation in the C. elegans Germline. Biophys J. 2015;109:2436-45 pubmed 出版商

Ryu H, Chung M, DobrzyÅ„ski M, Fey D, Blum Y, Lee S, et al. Frequency modulation of ERK activation dynamics rewires cell fate. Mol Syst Biol. 2015;11:838 pubmed 出版商

Van Boxtel A, Chesebro J, Heliot C, Ramel M, Stone R, Hill C. A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain. Dev Cell. 2015;35:175-85 pubmed 出版商

Bridgeman V, Wan E, Foo S, Nathan M, Welti J, Frentzas S, et al. Preclinical Evidence That Trametinib Enhances the Response to Antiangiogenic Tyrosine Kinase Inhibitors in Renal Cell Carcinoma. Mol Cancer Ther. 2016;15:172-83 pubmed 出版商

Lin K, Kao S, Lai C, Chen C, Wu C, Hsu H, et al. Tumor Suppressor Lzap Suppresses Wnt/β-Catenin Signaling to Promote Zebrafish Embryonic Ventral Cell Fates via the Suppression of Inhibitory Phosphorylation of Glycogen Synthase Kinase 3. J Biol Chem. 2015;290:29808-19 pubmed 出版商

Buscà R, Christen R, Lovern M, Clifford A, Yue J, Goss G, et al. ERK1 and ERK2 present functional redundancy in tetrapods despite higher evolution rate of ERK1. BMC Evol Biol. 2015;15:179 pubmed 出版商

Ohmoto T, Nishitsuji K, Yoshitani N, Mizuguchi M, Yanagisawa Y, Saito H, et al. K604, a specific acyl‑CoA:cholesterol acyltransferase 1 inhibitor, suppresses proliferation of U251‑MG glioblastoma cells. Mol Med Rep. 2015;12:6037-42 pubmed 出版商

Wauson E, Guerra M, Dyachok J, McGlynn K, Giles J, Ross E, et al. Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells. Mol Endocrinol. 2015;29:1114-22 pubmed 出版商

Abraham S, Scarcia M, Bagshaw R, McMahon K, Grant G, Harvey T, et al. A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis. Nat Commun. 2015;6:7286 pubmed 出版商

Wijayagunawardane M, Hambruch N, Haeger J, Pfarrer C. Effect of epidermal growth factor (EGF) on the phosphorylation of mitogen-activated protein kinase (MAPK) in the bovine oviduct in vitro: Alteration by heat stress. J Reprod Dev. 2015;61:383-9 pubmed 出版商

Wiemhoefer A, Stargardt A, van der Linden W, Renner M, Van Kesteren R, Stap J, et al. Tripeptidyl Peptidase II Mediates Levels of Nuclear Phosphorylated ERK1 and ERK2. Mol Cell Proteomics. 2015;14:2177-93 pubmed 出版商

Schmid T, Snoek L, Fröhli E, van der Bent M, Kammenga J, Hajnal A. Systemic Regulation of RAS/MAPK Signaling by the Serotonin Metabolite 5-HIAA. PLoS Genet. 2015;11:e1005236 pubmed 出版商

Legent K, Liu H, Treisman J. Drosophila Vps4 promotes Epidermal growth factor receptor signaling independently of its role in receptor degradation. Development. 2015;142:1480-91 pubmed 出版商

Gharbiah M, Nakamoto A, Johnson A, Lambert J, Nagy L. Ilyanassa Notch signaling implicated in dynamic signaling between all three germ layers. Int J Dev Biol. 2014;58:551-62 pubmed 出版商

Verma R, Marchese A. The endosomal sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of rapamycin antagonist DEPTOR. J Biol Chem. 2015;290:6810-24 pubmed 出版商

Preta G, Lotti V, Cronin J, Sheldon I. Protective role of the dynamin inhibitor Dynasore against the cholesterol-dependent cytolysin of Trueperella pyogenes. FASEB J. 2015;29:1516-28 pubmed 出版商

Arnold A, Rahman M, Lee M, Muehlhaeusser S, Katic I, Gaidatzis D, et al. Functional characterization of C. elegans Y-box-binding proteins reveals tissue-specific functions and a critical role in the formation of polysomes. Nucleic Acids Res. 2014;42:13353-69 pubmed 出版商

Tenin G, Clowes C, Wolton K, Krejci E, Wright J, Lovell S, et al. Erbb2 is required for cardiac atrial electrical activity during development. PLoS ONE. 2014;9:e107041 pubmed 出版商

Kim J, Vandamme D, Kim J, Munoz A, Kolch W, Cho K. Robustness and evolvability of the human signaling network. PLoS Comput Biol. 2014;10:e1003763 pubmed 出版商

Truscott M, Islam A, Lightfoot J, Lopez Bigas N, Frolov M. An intronic microRNA links Rb/E2F and EGFR signaling. PLoS Genet. 2014;10:e1004493 pubmed 出版商

Balenga N, Martínez Pinilla E, Kargl J, Schroder R, Peinhaupt M, Platzer W, et al. Heteromerization of GPR55 and cannabinoid CB2 receptors modulates signalling. Br J Pharmacol. 2014;171:5387-406 pubmed 出版商

Zaganjor E, Weil L, Gonzales J, Minna J, Cobb M. Ras transformation uncouples the kinesin-coordinated cellular nutrient response. Proc Natl Acad Sci U S A. 2014;111:10568-73 pubmed 出版商

Brenton A, Souvannaseng L, Cheung K, Anishchenko M, Brault A, Luckhart S. Engineered single nucleotide polymorphisms in the mosquito MEK docking site alter Plasmodium berghei development in Anopheles gambiae. Parasit Vectors. 2014;7:287 pubmed 出版商

Michailovici I, Harrington H, Azogui H, Yahalom Ronen Y, Plotnikov A, Ching S, et al. Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells. Development. 2014;141:2611-20 pubmed 出版商

Minna E, Romeo P, De Cecco L, Dugo M, Cassinelli G, Pilotti S, et al. miR-199a-3p displays tumor suppressor functions in papillary thyroid carcinoma. Oncotarget. 2014;5:2513-28 pubmed

Grepin R, Ambrosetti D, Marsaud A, Gastaud L, Amiel J, Pedeutour F, et al. The relevance of testing the efficacy of anti-angiogenesis treatments on cells derived from primary tumors: a new method for the personalized treatment of renal cell carcinoma. PLoS ONE. 2014;9:e89449 pubmed 出版商

Ashton Beaucage D, Udell C, Gendron P, Sahmi M, Lefrancois M, Baril C, et al. A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila. PLoS Biol. 2014;12:e1001809 pubmed 出版商

Maher K, Završnik J, Jerič Kokelj B, Vasiljeva O, Turk B, Kopitar Jerala N. Decreased IL-10 expression in stefin B-deficient macrophages is regulated by the MAP kinase and STAT-3 signaling pathways. FEBS Lett. 2014;588:720-6 pubmed 出版商

Yoshihara D, Kugita M, Sasaki M, Horie S, Nakanishi K, Abe T, et al. Telmisartan ameliorates fibrocystic liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease. PLoS ONE. 2013;8:e81480 pubmed 出版商

Zorde Khvalevsky E, Gabai R, Rachmut I, Horwitz E, Brunschwig Z, Orbach A, et al. Mutant KRAS is a druggable target for pancreatic cancer. Proc Natl Acad Sci U S A. 2013;110:20723-8 pubmed 出版商

Eberhard R, Stergiou L, Hofmann E, Hofmann J, Haenni S, Teo Y, et al. Ribosome synthesis and MAPK activity modulate ionizing radiation-induced germ cell apoptosis in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003943 pubmed 出版商

Johannessen C, Johnson L, Piccioni F, Townes A, Frederick D, Donahue M, et al. A melanocyte lineage program confers resistance to MAP kinase pathway inhibition. Nature. 2013;504:138-42 pubmed 出版商

Mendel I, Feige E, Yacov N, Salem Y, Levi I, Propheta Meiran O, et al. VB-201, an oxidized phospholipid small molecule, inhibits CD14- and Toll-like receptor-2-dependent innate cell activation and constrains atherosclerosis. Clin Exp Immunol. 2014;175:126-37 pubmed 出版商

Price J, Sheldon I. Granulosa cells from emerged antral follicles of the bovine ovary initiate inflammation in response to bacterial pathogen-associated molecular patterns via Toll-like receptor pathways. Biol Reprod. 2013;89:119 pubmed 出版商

de Souza W, Fortunato Miranda N, Robbs B, de Araujo W, de Freitas Junior J, Bastos L, et al. Claudin-3 overexpression increases the malignant potential of colorectal cancer cells: roles of ERK1/2 and PI3K-Akt as modulators of EGFR signaling. PLoS ONE. 2013;8:e74994 pubmed 出版商

Friedman S, Dani N, Rushton E, Broadie K. Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila. Dis Model Mech. 2013;6:1400-13 pubmed 出版商

Dombrowski C, Helledie T, Ling L, Grunert M, Canning C, Jones C, et al. FGFR1 signaling stimulates proliferation of human mesenchymal stem cells by inhibiting the cyclin-dependent kinase inhibitors p21(Waf1) and p27(Kip1). Stem Cells. 2013;31:2724-36 pubmed 出版商

Neutelings T, Lambert C, Nusgens B, Colige A. Effects of mild cold shock (25°C) followed by warming up at 37°C on the cellular stress response. PLoS ONE. 2013;8:e69687 pubmed 出版商

Guzman Y, Tronson N, Jovasevic V, Sato K, Guedea A, Mizukami H, et al. Fear-enhancing effects of septal oxytocin receptors. Nat Neurosci. 2013;16:1185-7 pubmed 出版商

Svensson K, Christianson H, Wittrup A, Bourseau Guilmain E, Lindqvist E, Svensson L, et al. Exosome uptake depends on ERK1/2-heat shock protein 27 signaling and lipid Raft-mediated endocytosis negatively regulated by caveolin-1. J Biol Chem. 2013;288:17713-24 pubmed 出版商

Sosa L, Gutierrez S, Petiti J, Vaca A, De Paul A, Torres A. Cooperative effect of E? and FGF2 on lactotroph proliferation triggered by signaling initiated at the plasma membrane. Am J Physiol Endocrinol Metab. 2013;305:E41-9 pubmed 出版商

Richani D, Ritter L, Thompson J, Gilchrist R. Mode of oocyte maturation affects EGF-like peptide function and oocyte competence. Mol Hum Reprod. 2013;19:500-9 pubmed 出版商

Gkirtzimanaki K, Gkouskou K, Oleksiewicz U, Nikolaidis G, Vyrla D, Liontos M, et al. TPL2 kinase is a suppressor of lung carcinogenesis. Proc Natl Acad Sci U S A. 2013;110:E1470-9 pubmed 出版商

Ramel M, Hill C. The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands. Dev Biol. 2013;378:170-82 pubmed 出版商

Duncan E, Benton M, Dearden P. Canonical terminal patterning is an evolutionary novelty. Dev Biol. 2013;377:245-61 pubmed 出版商

Zhou L, Luo H. Replication protein a links cell cycle progression and the onset of neurogenesis in Drosophila optic lobe development. J Neurosci. 2013;33:2873-88 pubmed 出版商

Chen P, Qin L, Barnes C, Charisse K, Yi T, Zhang X, et al. FGF regulates TGF-? signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Rep. 2012;2:1684-96 pubmed 出版商

Accornero P, Miretti S, Bersani F, Quaglino E, Martignani E, Baratta M. Met receptor acts uniquely for survival and morphogenesis of EGFR-dependent normal mammary epithelial and cancer cells. PLoS ONE. 2012;7:e44982 pubmed 出版商

Willoughby L, Schlosser T, Manning S, Parisot J, Street I, Richardson H, et al. An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery. Dis Model Mech. 2013;6:521-9 pubmed 出版商

Banton M, Tunnacliffe A. MAPK phosphorylation is implicated in the adaptation to desiccation stress in nematodes. J Exp Biol. 2012;215:4288-98 pubmed 出版商

Nakdimon I, Walser M, Fröhli E, Hajnal A. PTEN negatively regulates MAPK signaling during Caenorhabditis elegans vulval development. PLoS Genet. 2012;8:e1002881 pubmed 出版商

Kabara E, Coussens P. Infection of Primary Bovine Macrophages with Mycobacterium avium Subspecies paratuberculosis Suppresses Host Cell Apoptosis. Front Microbiol. 2012;3:215 pubmed 出版商

Magudia K, Lahoz A, Hall A. K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc. J Cell Biol. 2012;198:185-94 pubmed 出版商

Stulberg M, Lin A, Zhao H, Holley S. Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud. Dev Biol. 2012;369:298-307 pubmed 出版商

Nölting S, Garcia E, Alusi G, Giubellino A, Pacak K, Korbonits M, et al. Combined blockade of signalling pathways shows marked anti-tumour potential in phaeochromocytoma cell lines. J Mol Endocrinol. 2012;49:79-96 pubmed 出版商

Sridharan J, Haremaki T, Jin Y, Teegala S, Weinstein D. Xmab21l3 mediates dorsoventral patterning in Xenopus laevis. Mech Dev. 2012;129:136-46 pubmed 出版商

Suzuki A, Harada H, Nakamura H. Nuclear translocation of FGF8 and its implication to induce Sprouty2. Dev Growth Differ. 2012;54:463-73 pubmed 出版商

Ferguson J, Arozarena I, Ehrhardt M, Wellbrock C. Combination of MEK and SRC inhibition suppresses melanoma cell growth and invasion. Oncogene. 2013;32:86-96 pubmed 出版商

Vergani E, Vallacchi V, Frigerio S, Deho P, Mondellini P, Perego P, et al. Identification of MET and SRC activation in melanoma cell lines showing primary resistance to PLX4032. Neoplasia. 2011;13:1132-42 pubmed

Kanade S, Eckert R. Protein arginine methyltransferase 5 (PRMT5) signaling suppresses protein kinase C?- and p38?-dependent signaling and keratinocyte differentiation. J Biol Chem. 2012;287:7313-23 pubmed 出版商

Ross J, Gherardi E, Mallorquí Fernández N, Bocci M, Sobkowicz A, Rees M, et al. Protein engineered variants of hepatocyte growth factor/scatter factor promote proliferation of primary human hepatocytes and in rodent liver. Gastroenterology. 2012;142:897-906 pubmed 出版商

Spitzer P, Schieb H, Kamrowski Kruck H, Otto M, Chiasserini D, Parnetti L, et al. Evidence for Elevated Cerebrospinal Fluid ERK1/2 Levels in Alzheimer Dementia. Int J Alzheimers Dis. 2011;2011:739847 pubmed 出版商

Cronin J, Turner M, Goetze L, Bryant C, Sheldon I. Toll-like receptor 4 and MYD88-dependent signaling mechanisms of the innate immune system are essential for the response to lipopolysaccharide by epithelial and stromal cells of the bovine endometrium. Biol Reprod. 2012;86:51 pubmed 出版商

Bromfield J, Sheldon I. Lipopolysaccharide initiates inflammation in bovine granulosa cells via the TLR4 pathway and perturbs oocyte meiotic progression in vitro. Endocrinology. 2011;152:5029-40 pubmed 出版商

Giles N, Pavey S, Pinder A, Gabrielli B. Multiple melanoma susceptibility factors function in an ultraviolet radiation response pathway in skin. Br J Dermatol. 2012;166:362-71 pubmed 出版商

Shavit E, Michaelson D, Chapman J. Anatomical localization of protease-activated receptor-1 and protease-mediated neuroglial crosstalk on peri-synaptic astrocytic endfeet. J Neurochem. 2011;119:460-73 pubmed 出版商

Eisenberg S, Beckett A, Prior I, Dekker F, Hedberg C, Waldmann H, et al. Raft protein clustering alters N-Ras membrane interactions and activation pattern. Mol Cell Biol. 2011;31:3938-52 pubmed 出版商

Cooley J, Whitaker S, Sweeney S, Fraser S, Davidson B. Cytoskeletal polarity mediates localized induction of the heart progenitor lineage. Nat Cell Biol. 2011;13:952-7 pubmed 出版商

Amsterdam A, Shezen E, Raanan C, Schreiber L, Prus D, Slilat Y, et al. Nuclear localization of phosphorylated ERK1 and ERK2 as markers for the progression of ovarian cancer. Int J Oncol. 2011;39:649-56 pubmed 出版商

Cagnol S, Mansour A, Van Obberghen Schilling E, Chambard J. Raf-1 activation prevents caspase 9 processing downstream of apoptosome formation. J Signal Transduct. 2011;2011:834948 pubmed 出版商

Gibbens Y, Warren J, Gilbert L, O Connor M. Neuroendocrine regulation of Drosophila metamorphosis requires TGFbeta/Activin signaling. Development. 2011;138:2693-703 pubmed 出版商

Hashimoto H, Enomoto T, Enomoto A, Kumano G, Nishida H. The transcription factor FoxB mediates temporal loss of cellular competence for notochord induction in ascidian embryos. Development. 2011;138:2591-600 pubmed 出版商

Navon H, Bromberg Y, Sperling O, Shani E. Neuroprotection by NMDA preconditioning against glutamate cytotoxicity is mediated through activation of ERK 1/2, inactivation of JNK, and by prevention of glutamate-induced CREB inactivation. J Mol Neurosci. 2012;46:100-8 pubmed 出版商

Al Omari M, Korenbaum E, Ballmaier M, Lehmann U, Jonigk D, Manstein D, et al. Acute-phase protein ?1-antitrypsin inhibits neutrophil calpain I and induces random migration. Mol Med. 2011;17:865-74 pubmed 出版商

Wurm A, Iandiev I, Uhlmann S, Wiedemann P, Reichenbach A, Bringmann A, et al. Effects of ischemia-reperfusion on physiological properties of Müller glial cells in the porcine retina. Invest Ophthalmol Vis Sci. 2011;52:3360-7 pubmed 出版商

Biteau B, Jasper H. EGF signaling regulates the proliferation of intestinal stem cells in Drosophila. Development. 2011;138:1045-55 pubmed 出版商

Mayo L, Levy A, Jacob Hirsch J, Amariglio N, Rechavi G, Stein R. Bid regulates the immunological profile of murine microglia and macrophages. Glia. 2011;59:397-412 pubmed 出版商

Mazot P, Cazes A, Boutterin M, Figueiredo A, Raynal V, Combaret V, et al. The constitutive activity of the ALK mutated at positions F1174 or R1275 impairs receptor trafficking. Oncogene. 2011;30:2017-25 pubmed 出版商

Arozarena I, Sanchez Laorden B, Packer L, Hidalgo Carcedo C, Hayward R, Viros A, et al. Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A. Cancer Cell. 2011;19:45-57 pubmed 出版商

Valluet A, Hmitou I, Davis S, Druillennec S, Larcher M, Laroche S, et al. B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouse. PLoS ONE. 2010;5:e15272 pubmed 出版商

Yoshihara D, Kurahashi H, Morita M, Kugita M, Hiki Y, Aukema H, et al. PPAR-gamma agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease. Am J Physiol Renal Physiol. 2011;300:F465-74 pubmed 出版商

Ludwig A, Otto G, Riento K, Hams E, Fallon P, Nichols B. Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment. J Cell Biol. 2010;191:771-81 pubmed 出版商

Shkreta L, Michelle L, Toutant J, Tremblay M, Chabot B. The DNA damage response pathway regulates the alternative splicing of the apoptotic mediator Bcl-x. J Biol Chem. 2011;286:331-40 pubmed 出版商

Ashton Beaucage D, Udell C, Lavoie H, Baril C, Lefrancois M, Chagnon P, et al. The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila. Cell. 2010;143:251-62 pubmed 出版商

Gutzwiller L, Witt L, Gresser A, Burns K, Cook T, Gebelein B. Proneural and abdominal Hox inputs synergize to promote sensory organ formation in the Drosophila abdomen. Dev Biol. 2010;348:231-43 pubmed 出版商

Rousso T, Lynch J, Yogev S, Roth S, Schejter E, Shilo B. Generation of distinct signaling modes via diversification of the Egfr ligand-processing cassette. Development. 2010;137:3427-37 pubmed 出版商

Sasseville M, Ritter L, Nguyen T, Liu F, Mottershead D, Russell D, et al. Growth differentiation factor 9 signaling requires ERK1/2 activity in mouse granulosa and cumulus cells. J Cell Sci. 2010;123:3166-76 pubmed 出版商

Clary L, Okkema P. The EGR family gene egrh-1 functions non-autonomously in the control of oocyte meiotic maturation and ovulation in C. elegans. Development. 2010;137:3129-37 pubmed 出版商

Ortholan C, Durivault J, Hannoun Levi J, Guyot M, Bourcier C, Ambrosetti D, et al. Bevacizumab/docetaxel association is more efficient than docetaxel alone in reducing breast and prostate cancer cell growth: a new paradigm for understanding the therapeutic effect of combined treatment. Eur J Cancer. 2010;46:3022-36 pubmed 出版商

Danovi D, Cremona C, Machado da Silva G, Basu S, Noon L, Parrinello S, et al. A genetic screen for anchorage-independent proliferation in mammalian cells identifies a membrane-bound neuregulin. PLoS ONE. 2010;5:e11774 pubmed 出版商

Bermudez O, Jouandin P, Rottier J, Bourcier C, Pages G, Gimond C. Post-transcriptional regulation of the DUSP6/MKP-3 phosphatase by MEK/ERK signaling and hypoxia. J Cell Physiol. 2011;226:276-84 pubmed 出版商

Javle M, Shroff R, Xiong H, Varadhachary G, Fogelman D, Reddy S, et al. Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies. BMC Cancer. 2010;10:368 pubmed 出版商

Okuyama T, Inoue H, Ookuma S, Satoh T, Kano K, Honjoh S, et al. The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans. J Biol Chem. 2010;285:30274-81 pubmed 出版商

Leak R, Castro S, Jaumotte J, Smith A, Zigmond M. Assaying multiple biochemical variables from the same tissue sample. J Neurosci Methods. 2010;191:234-8 pubmed 出版商

Dilly M, Hambruch N, Haeger J, Pfarrer C. Epidermal growth factor (EGF) induces motility and upregulates MMP-9 and TIMP-1 in bovine trophoblast cells. Mol Reprod Dev. 2010;77:622-9 pubmed 出版商

Dias E, Matos P, Pereira P, Batoreu M, Silva M, Jordan P. Microcystin-LR activates the ERK1/2 kinases and stimulates the proliferation of the monkey kidney-derived cell line Vero-E6. Toxicol In Vitro. 2010;24:1689-95 pubmed 出版商

Subramaniyam D, Zhou H, Liang M, Welte T, Mahadeva R, Janciauskiene S. Cholesterol rich lipid raft microdomains are gateway for acute phase protein, SERPINA1. Int J Biochem Cell Biol. 2010;42:1562-70 pubmed 出版商

Siekhaus D, Haesemeyer M, Moffitt O, Lehmann R. RhoL controls invasion and Rap1 localization during immune cell transmigration in Drosophila. Nat Cell Biol. 2010;12:605-10 pubmed 出版商

Majumdar N, Paez G, Inamdar S, D Rozario M, Marenda D. MAP kinase phosphorylation is dispensable for cell division, but required for cell growth in Drosophila. Fly (Austin). 2010;4:204-12 pubmed 出版商

Chrétien M, Zhang M, Jackson M, Kapus A, Langille B. Mechanotransduction by endothelial cells is locally generated, direction-dependent, and ligand-specific. J Cell Physiol. 2010;224:352-61 pubmed 出版商

Herr A, Mckenzie L, Suryadinata R, Sadowski M, Parsons L, Sarcevic B, et al. Geminin and Brahma act antagonistically to regulate EGFR-Ras-MAPK signaling in Drosophila. Dev Biol. 2010;344:36-51 pubmed 出版商

Smith E, Cai K, Smedberg J, Ribeiro M, Rula M, Slater C, et al. Nuclear entry of activated MAPK is restricted in primary ovarian and mammary epithelial cells. PLoS ONE. 2010;5:e9295 pubmed 出版商

Rennalls L, Seidl T, Larkin J, Wellbrock C, Gore M, Eisen T, et al. The melanocortin receptor agonist NDP-MSH impairs the allostimulatory function of dendritic cells. Immunology. 2010;129:610-9 pubmed 出版商

Lidke D, Huang F, Post J, Rieger B, Wilsbacher J, Thomas J, et al. ERK nuclear translocation is dimerization-independent but controlled by the rate of phosphorylation. J Biol Chem. 2010;285:3092-102 pubmed 出版商

Hambruch N, Haeger J, Dilly M, Pfarrer C. EGF stimulates proliferation in the bovine placental trophoblast cell line F3 via Ras and MAPK. Placenta. 2010;31:67-74 pubmed 出版商

Schouest K, Kurasawa Y, Furuta T, Hisamoto N, Matsumoto K, Schumacher J. The germinal center kinase GCK-1 is a negative regulator of MAP kinase activation and apoptosis in the C. elegans germline. PLoS ONE. 2009;4:e7450 pubmed 出版商

Nentwich O, Dingwell K, Nordheim A, Smith J. Downstream of FGF during mesoderm formation in Xenopus: the roles of Elk-1 and Egr-1. Dev Biol. 2009;336:313-26 pubmed 出版商

Wilson M, Dearden P. Tailless patterning functions are conserved in the honeybee even in the absence of Torso signaling. Dev Biol. 2009;335:276-87 pubmed 出版商

Argast G, Croy C, Couts K, Zhang Z, Litman E, Chan D, et al. Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells. Oncogene. 2009;28:2697-709 pubmed 出版商

Corl A, Berger K, Ophir Shohat G, Gesch J, Simms J, Bartlett S, et al. Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors. Cell. 2009;137:949-60 pubmed 出版商

Yan H, Chin M, Horvath E, Kane E, Pfleger C. Impairment of ubiquitylation by mutation in Drosophila E1 promotes both cell-autonomous and non-cell-autonomous Ras-ERK activation in vivo. J Cell Sci. 2009;122:1461-70 pubmed 出版商

Martin P, Boulukos K, Poggi M, Pognonec P. Long-term extracellular signal-related kinase activation following cadmium intoxication is negatively regulated by a protein kinase C-dependent pathway affecting cadmium transport. FEBS J. 2009;276:1667-79 pubmed 出版商

Knirsh R, Ben Dror I, Spangler B, Matthews G, Kuphal S, Bosserhoff A, et al. Loss of E-cadherin-mediated cell-cell contacts activates a novel mechanism for up-regulation of the proto-oncogene c-Jun. Mol Biol Cell. 2009;20:2121-9 pubmed 出版商

Azhar M, Runyan R, Gard C, Sanford L, Miller M, Andringa A, et al. Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development. Dev Dyn. 2009;238:431-42 pubmed 出版商

Wairkar Y, Toda H, Mochizuki H, Furukubo Tokunaga K, Tomoda T, DiAntonio A. Unc-51 controls active zone density and protein composition by downregulating ERK signaling. J Neurosci. 2009;29:517-28 pubmed 出版商

Marchi M, D Antoni A, Formentini I, Parra R, Brambilla R, Ratto G, et al. The N-terminal domain of ERK1 accounts for the functional differences with ERK2. PLoS ONE. 2008;3:e3873 pubmed 出版商

Young J, Becker A, Medeiros J, Shapiro V, Wang A, Farrar J, et al. The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions. Mol Immunol. 2008;45:3756-66 pubmed 出版商

Hilberg F, Roth G, Krssak M, Kautschitsch S, Sommergruber W, Tontsch Grunt U, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res. 2008;68:4774-82 pubmed 出版商

Yin Y, White A, Huh S, Hilton M, Kanazawa H, Long F, et al. An FGF-WNT gene regulatory network controls lung mesenchyme development. Dev Biol. 2008;319:426-36 pubmed 出版商

Kilic U, Kilic E, Matter C, Bassetti C, Hermann D. TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration. Neurobiol Dis. 2008;31:33-40 pubmed 出版商

Nakamura T, Mito T, Miyawaki K, Ohuchi H, Noji S. EGFR signaling is required for re-establishing the proximodistal axis during distal leg regeneration in the cricket Gryllus bimaculatus nymph. Dev Biol. 2008;319:46-55 pubmed 出版商

Lahne M, Gale J. Damage-induced activation of ERK1/2 in cochlear supporting cells is a hair cell death-promoting signal that depends on extracellular ATP and calcium. J Neurosci. 2008;28:4918-28 pubmed 出版商

Zhao H, Tanegashima K, Ro H, Dawid I. Lrig3 regulates neural crest formation in Xenopus by modulating Fgf and Wnt signaling pathways. Development. 2008;135:1283-93 pubmed 出版商

Mazurkiewicz P, Thomas J, Thompson J, Liu M, Arbibe L, Sansonetti P, et al. SpvC is a Salmonella effector with phosphothreonine lyase activity on host mitogen-activated protein kinases. Mol Microbiol. 2008;67:1371-83 pubmed 出版商

Mayshar Y, Rom E, Chumakov I, Kronman A, Yayon A, Benvenisty N. Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of human embryonic stem cell self-renewal. Stem Cells. 2008;26:767-74 pubmed 出版商

Hédou G, Koshibu K, Farinelli M, Kilic E, Gee C, Kilic U, et al. Protein phosphatase 1-dependent bidirectional synaptic plasticity controls ischemic recovery in the adult brain. J Neurosci. 2008;28:154-62 pubmed 出版商

Sampaio C, Dance M, Montagner A, Edouard T, Malet N, Perret B, et al. Signal strength dictates phosphoinositide 3-kinase contribution to Ras/extracellular signal-regulated kinase 1 and 2 activation via differential Gab1/Shp2 recruitment: consequences for resistance to epidermal growth factor receptor inhibition. Mol Cell Biol. 2008;28:587-600 pubmed

Hayashi M, Chin G, Villeneuve A. C. elegans germ cells switch between distinct modes of double-strand break repair during meiotic prophase progression. PLoS Genet. 2007;3:e191 pubmed

Lefloch R, Pouyssegur J, Lenormand P. Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels. Mol Cell Biol. 2008;28:511-27 pubmed

Kourakis M, Smith W. A conserved role for FGF signaling in chordate otic/atrial placode formation. Dev Biol. 2007;312:245-57 pubmed

Koop D, Richards G, Wanninger A, Gunter H, Degnan B. The role of MAPK signaling in patterning and establishing axial symmetry in the gastropod Haliotis asinina. Dev Biol. 2007;311:200-12 pubmed

Hall J, Kurdi Y, Hsu S, Cuozzo J, Liu J, Telliez J, et al. Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood. J Biol Chem. 2007;282:33295-304 pubmed

Moniz S, Verissimo F, Matos P, Brazão R, Silva E, Kotelevets L, et al. Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2. Oncogene. 2007;26:6071-81 pubmed

Niemann H, J ger V, Butler P, van den Heuvel J, Schmidt S, Ferraris D, et al. Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB. Cell. 2007;130:235-46 pubmed 出版商

Doroquez D, Orr Weaver T, Rebay I. Split ends antagonizes the Notch and potentiates the EGFR signaling pathways during Drosophila eye development. Mech Dev. 2007;124:792-806 pubmed

Hurtado C, De Robertis E. Neural induction in the absence of organizer in salamanders is mediated by MAPK. Dev Biol. 2007;307:282-9 pubmed

Prickett T, Brautigan D. Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3. Mol Cell Biol. 2007;27:4217-27 pubmed

Canning C, Lee L, Irving C, Mason I, Jones C. Sustained interactive Wnt and FGF signaling is required to maintain isthmic identity. Dev Biol. 2007;305:276-86 pubmed

Kim G, Kumano G, Nishida H. Cell fate polarization in ascidian mesenchyme/muscle precursors by directed FGF signaling and role for an additional ectodermal FGF antagonizing signal in notochord/nerve cord precursors. Development. 2007;134:1509-18 pubmed

Matsubara Y, Kawasaki I, Urushiyama S, Yasuda T, Shirakata M, Iino Y, et al. The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans. Genes Cells. 2007;12:407-20 pubmed

Szewczyk N, Peterson B, Barmada S, Parkinson L, Jacobson L. Opposed growth factor signals control protein degradation in muscles of Caenorhabditis elegans. EMBO J. 2007;26:935-43 pubmed

Crepaldi T, Bersani F, Scuoppo C, Accornero P, Prunotto C, Taulli R, et al. Conditional activation of MET in differentiated skeletal muscle induces atrophy. J Biol Chem. 2007;282:6812-22 pubmed

Sasagawa Y, Sato S, Ogura T, Higashitani A. C. elegans RBX-2-CUL-5- and RBX-1-CUL-2-based complexes are redundant for oogenesis and activation of the MAP kinase MPK-1. FEBS Lett. 2007;581:145-50 pubmed

Kilic U, Kilic E, Järve A, Guo Z, Spudich A, Bieber K, et al. Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways. J Neurosci. 2006;26:12439-46 pubmed

Walker J, Tchoudakova A, McKenney P, Brill S, Wu D, Cowley G, et al. Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons. Genes Dev. 2006;20:3311-23 pubmed

Röttinger E, Croce J, Lhomond G, Besnardeau L, Gache C, Lepage T. Nemo-like kinase (NLK) acts downstream of Notch/Delta signalling to downregulate TCF during mesoderm induction in the sea urchin embryo. Development. 2006;133:4341-53 pubmed

Whitten S, Miller M. The role of gap junctions in Caenorhabditis elegans oocyte maturation and fertilization. Dev Biol. 2007;301:432-46 pubmed

Eisenberg S, Shvartsman D, Ehrlich M, Henis Y. Clustering of raft-associated proteins in the external membrane leaflet modulates internal leaflet H-ras diffusion and signaling. Mol Cell Biol. 2006;26:7190-200 pubmed

Cadd V, Hogg P, Harris A, Feller S. Molecular profiling of signalling proteins for effects induced by the anti-cancer compound GSAO with 400 antibodies. BMC Cancer. 2006;6:155 pubmed

Kim M, Lee J, Koh H, Lee S, Jang C, Chung C, et al. Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development. EMBO J. 2006;25:3056-67 pubmed

Germano S, Barberis D, Santoro M, Penengo L, Citri A, Yarden Y, et al. Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling. J Biol Chem. 2006;281:21710-9 pubmed

Croft D, Olson M. The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms. Mol Cell Biol. 2006;26:4612-27 pubmed

Berger I, Stahl S, Rychkova N, Felbor U. VEGF receptors on PC12 cells mediate transient activation of ERK1/2 and Akt: comparison of nerve growth factor and vascular endothelial growth factor. J Negat Results Biomed. 2006;5:8 pubmed

Kilic E, Kilic U, Wang Y, Bassetti C, Marti H, Hermann D. The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia. FASEB J. 2006;20:1185-7 pubmed

Maitra S, Kulikauskas R, Gavilan H, Fehon R. The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling. Curr Biol. 2006;16:702-9 pubmed

You Y, Kim J, Cobb M, Avery L. Starvation activates MAP kinase through the muscarinic acetylcholine pathway in Caenorhabditis elegans pharynx. Cell Metab. 2006;3:237-45 pubmed

Raines K, Cao G, Lee E, Rosen G, Shapiro P. Neuronal nitric oxide synthase-induced S-nitrosylation of H-Ras inhibits calcium ionophore-mediated extracellular-signal-regulated kinase activity. Biochem J. 2006;397:329-36 pubmed

Morotti A, Cilloni D, Messa F, Arruga F, Defilippi I, Carturan S, et al. Valproate enhances imatinib-induced growth arrest and apoptosis in chronic myeloid leukemia cells. Cancer. 2006;106:1188-96 pubmed

Reversade B, De Robertis E. Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field. Cell. 2005;123:1147-60 pubmed

Ozaki K, Miyazaki S, Tanimura S, Kohno M. Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms. J Cell Sci. 2005;118:5861-71 pubmed

Lours C, Dietrich S. The dissociation of the Fgf-feedback loop controls the limbless state of the neck. Development. 2005;132:5553-64 pubmed

Marenda D, Vrailas A, Rodrigues A, Cook S, Powers M, Lorenzen J, et al. MAP kinase subcellular localization controls both pattern and proliferation in the developing Drosophila wing. Development. 2006;133:43-51 pubmed

Kfir S, Ehrlich M, Goldshmid A, Liu X, Kloog Y, Henis Y. Pathway- and expression level-dependent effects of oncogenic N-Ras: p27(Kip1) mislocalization by the Ral-GEF pathway and Erk-mediated interference with Smad signaling. Mol Cell Biol. 2005;25:8239-50 pubmed

Wellbrock C, Marais R. Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation. J Cell Biol. 2005;170:703-8 pubmed

Walters J, Munoz C, Paaby A, Dinardo S. Serrate-Notch signaling defines the scope of the initial denticle field by modulating EGFR activation. Dev Biol. 2005;286:415-26 pubmed

Perlson E, Hanz S, Ben Yaakov K, Segal Ruder Y, Seger R, Fainzilber M. Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve. Neuron. 2005;45:715-26 pubmed

MacKinnon A, Tufail Hanif U, Lucas C, Jodrell D, Haslett C, Sethi T. Expression of V1A and GRP receptors leads to cellular transformation and increased sensitivity to substance-P analogue-induced growth inhibition. Br J Cancer. 2005;92:522-31 pubmed

Hancock C, Dangi S, Shapiro P. Protein phosphatase 2A activity associated with Golgi membranes during the G2/M phase may regulate phosphorylation of ERK2. J Biol Chem. 2005;280:11590-8 pubmed

Wilson R, Vogelsang E, Leptin M. FGF signalling and the mechanism of mesoderm spreading in Drosophila embryos. Development. 2005;132:491-501 pubmed

Kilic E, Kilic U, Matter C, Luscher T, Bassetti C, Hermann D. Aggravation of focal cerebral ischemia by tissue plasminogen activator is reversed by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor but does not depend on endothelial NO synthase. Stroke. 2005;36:332-6 pubmed

Macias A, Romero N, Martin F, Suárez L, Rosa A, Morata G. PVF1/PVR signaling and apoptosis promotes the rotation and dorsal closure of the Drosophila male terminalia. Int J Dev Biol. 2004;48:1087-94 pubmed

Brockbank E, Bridges J, Marshall C, Sahai E. Integrin beta1 is required for the invasive behaviour but not proliferation of squamous cell carcinoma cells in vivo. Br J Cancer. 2005;92:102-12 pubmed

Plumb Rudewiez N, Clotman F, Strick Marchand H, Pierreux C, Weiss M, Rousseau G, et al. Transcription factor HNF-6/OC-1 inhibits the stimulation of the HNF-3alpha/Foxa1 gene by TGF-beta in mouse liver. Hepatology. 2004;40:1266-74 pubmed

Kilic U, Kilic E, Soliz J, Bassetti C, Gassmann M, Hermann D. Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2. FASEB J. 2005;19:249-51 pubmed

Liu J, Puscheck E, Wang F, Trostinskaia A, Barisic D, Maniere G, et al. Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells. Reproduction. 2004;128:643-54 pubmed

Wang Y, Wang F, Sun T, Trostinskaia A, Wygle D, Puscheck E, et al. Entire mitogen activated protein kinase (MAPK) pathway is present in preimplantation mouse embryos. Dev Dyn. 2004;231:72-87 pubmed

Schroeder J, Masri A, Adriance M, Tessier J, Kotlarczyk K, Thompson M, et al. MUC1 overexpression results in mammary gland tumorigenesis and prolonged alveolar differentiation. Oncogene. 2004;23:5739-47 pubmed

Salvatore M, Zhang J, Large D, Wilson P, Gash C, Thomas T, et al. Striatal GDNF administration increases tyrosine hydroxylase phosphorylation in the rat striatum and substantia nigra. J Neurochem. 2004;90:245-54 pubmed

Darash Yahana M, Pikarsky E, Abramovitch R, Zeira E, Pal B, Karplus R, et al. Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis. FASEB J. 2004;18:1240-2 pubmed

Marchetti A, Cecchinelli B, D ANGELO M, D Orazi G, Crescenzi M, Sacchi A, et al. p53 can inhibit cell proliferation through caspase-mediated cleavage of ERK2/MAPK. Cell Death Differ. 2004;11:596-607 pubmed

Liu Y, Porta A, Peng X, Gengaro K, Cunningham E, Li H, et al. Prevention of glucocorticoid-induced apoptosis in osteocytes and osteoblasts by calbindin-D28k. J Bone Miner Res. 2004;19:479-90 pubmed

Röttinger E, Besnardeau L, Lepage T. A Raf/MEK/ERK signaling pathway is required for development of the sea urchin embryo micromere lineage through phosphorylation of the transcription factor Ets. Development. 2004;131:1075-87 pubmed

Le Gallic L, Virgilio L, Cohen P, Biteau B, Mavrothalassitis G. ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression. Mol Cell Biol. 2004;24:1206-18 pubmed

Vial E, Marshall C. Elevated ERK-MAP kinase activity protects the FOS family member FRA-1 against proteasomal degradation in colon carcinoma cells. J Cell Sci. 2003;116:4957-63 pubmed

Raines K, Cao G, Porsuphatana S, Tsai P, Rosen G, Shapiro P. Nitric oxide inhibition of ERK1/2 activity in cells expressing neuronal nitric-oxide synthase. J Biol Chem. 2004;279:3933-40 pubmed

Fujita H, Omori S, Ishikura K, Hida M, Awazu M. ERK and p38 mediate high-glucose-induced hypertrophy and TGF-beta expression in renal tubular cells. Am J Physiol Renal Physiol. 2004;286:F120-6 pubmed

Corson L, Yamanaka Y, Lai K, Rossant J. Spatial and temporal patterns of ERK signaling during mouse embryogenesis. Development. 2003;130:4527-37 pubmed

Coleman M, Marshall C, Olson M. Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation. EMBO J. 2003;22:2036-46 pubmed

Nagao S, Yamaguchi T, Kusaka M, Maser R, Takahashi H, Cowley B, et al. Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease. Kidney Int. 2003;63:427-37 pubmed

Kovalenko D, Yang X, Nadeau R, Harkins L, Friesel R. Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation. J Biol Chem. 2003;278:14087-91 pubmed

Black E, Walker M, Clark W, MacLaren A, Gillespie D. Cell transformation by v-Jun deactivates ERK MAP kinase signalling. Oncogene. 2002;21:6540-8 pubmed

Light Y, Paterson H, Marais R. 14-3-3 antagonizes Ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity. Mol Cell Biol. 2002;22:4984-96 pubmed

Sullivan K, Rubin G. The Ca(2+)-calmodulin-activated protein phosphatase calcineurin negatively regulates EGF receptor signaling in Drosophila development. Genetics. 2002;161:183-93 pubmed

Dumaz N, Light Y, Marais R. Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms. Mol Cell Biol. 2002;22:3717-28 pubmed

Magne N, Fischel J, Dubreuil A, Formento P, Poupon M, Laurent Puig P, et al. Influence of epidermal growth factor receptor (EGFR), p53 and intrinsic MAP kinase pathway status of tumour cells on the antiproliferative effect of ZD1839 ("Iressa"). Br J Cancer. 2002;86:1518-23 pubmed

Zhao M, Pu J, Forrester J, McCaig C. Membrane lipids, EGF receptors, and intracellular signals colocalize and are polarized in epithelial cells moving directionally in a physiological electric field. FASEB J. 2002;16:857-9 pubmed

Muller M, Morotti A, Ponzetto C. Activation of NF-kappaB is essential for hepatocyte growth factor-mediated proliferation and tubulogenesis. Mol Cell Biol. 2002;22:1060-72 pubmed

Erdman R, Stahl R, Rothblum K, Chernousov M, Carey D. Schwann cell adhesion to a novel heparan sulfate binding site in the N-terminal domain of alpha 4 type V collagen is mediated by syndecan-3. J Biol Chem. 2002;277:7619-25 pubmed

Anselmo A, Bumeister R, Thomas J, White M. Critical contribution of linker proteins to Raf kinase activation. J Biol Chem. 2002;277:5940-3 pubmed

Haase I, Hobbs R, Romero M, Broad S, Watt F. A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis. J Clin Invest. 2001;108:527-36 pubmed

Cha H, Shapiro P. Tyrosine-phosphorylated extracellular signal--regulated kinase associates with the Golgi complex during G2/M phase of the cell cycle: evidence for regulation of Golgi structure. J Cell Biol. 2001;153:1355-67 pubmed

Nutt S, Dingwell K, Holt C, Amaya E. Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterning. Genes Dev. 2001;15:1152-66 pubmed

Pearson G, Robinson F, Beers Gibson T, Xu B, Karandikar M, Berman K, et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev. 2001;22:153-83 pubmed

Chiloeches A, Mason C, Marais R. S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3. Mol Cell Biol. 2001;21:2423-34 pubmed

Hoshino R, Tanimura S, Watanabe K, Kataoka T, Kohno M. Blockade of the extracellular signal-regulated kinase pathway induces marked G1 cell cycle arrest and apoptosis in tumor cells in which the pathway is constitutively activated: up-regulation of p27(Kip1). J Biol Chem. 2001;276:2686-92 pubmed

Vuong H, Patterson T, Shapiro P, Kalvakolanu D, Wu R, Ma W, et al. Phorbol ester-induced expression of airway squamous cell differentiation marker, SPRR1B, is regulated by protein kinase Cdelta /Ras/MEKK1/MKK1-dependent/AP-1 signal transduction pathway. J Biol Chem. 2000;275:32250-9 pubmed

Kulkarni S, Gish G, van der Geer P, Henkemeyer M, Pawson T. Role of p120 Ras-GAP in directed cell movement. J Cell Biol. 2000;149:457-70 pubmed

Nobes C, Hall A. Rho GTPases control polarity, protrusion, and adhesion during cell movement. J Cell Biol. 1999;144:1235-44 pubmed

Schnepp B, Donaldson T, Grumbling G, Ostrowski S, Schweitzer R, Shilo B, et al. EGF domain swap converts a drosophila EGF receptor activator into an inhibitor. Genes Dev. 1998;12:908-13 pubmed