公司名称 :
其他品牌 :
FLUKA, Sigma-Aldrich, Roche Applied Science
产品类型 :
产品名称 :
Anti-MAP Kinase, Activated (Diphosphorylated ERK-1&2) antibody, Mouse monoclonal
目录 :
克隆性 :
宿主 :
共轭标签 :
克隆名称 :
反应物种 :
人类, 小鼠, 大鼠, , pigs , 斑马鱼, roundworm
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-冰冻切片, reverse phase protein lysate microarray
更多信息或购买 :
文章摘录数: 90
  • 免疫印迹; 人类; 图 3b
Gomes A, Ilter D, Low V, Rosenzweig A, Shen Z, Schild T, et al. Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Cancer Cell. 2019;36:402-417.e13 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 1a
  • 免疫印迹; 小鼠; 图 1c
Kidger A, Rushworth L, Stellzig J, Davidson J, Bryant C, Bayley C, et al. Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling. Proc Natl Acad Sci U S A. 2017;114:E317-E326 pubmed 出版商
  • 免疫印迹; pigs ; 图 1b
Ismail H, Didangelos A, Vincent T, Saklatvala J. Rapid Activation of Transforming Growth Factor ?-Activated Kinase 1 in Chondrocytes by Phosphorylation and K63 -Linked Polyubiquitination Upon Injury to Animal Articular Cartilage. Arthritis Rheumatol. 2017;69:565-575 pubmed 出版商
  • 免疫印迹; 人类; 图 7e
Schütz I, López Hernández T, Gao Q, Puchkov D, Jabs S, Nordmeyer D, et al. Lysosomal Dysfunction Caused by Cellular Accumulation of Silica Nanoparticles. J Biol Chem. 2016;291:14170-84 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:500; 图 1
  • 免疫印迹; 小鼠; 1:2000; 图 2
Sipieter F, Cappe B, Gonzalez Pisfil M, Spriet C, Bodart J, Cailliau Maggio K, et al. Novel Reporter for Faithful Monitoring of ERK2 Dynamics in Living Cells and Model Organisms. PLoS ONE. 2015;10:e0140924 pubmed 出版商
  • 免疫组化-冰冻切片; 斑马鱼; 1:50; 图 s5
Westcot S, Hatzold J, Urban M, Richetti S, Skuster K, Harm R, et al. Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Required during Median Fin Fold Morphogenesis. PLoS ONE. 2015;10:e0130688 pubmed 出版商
  • 免疫印迹; 人类; 图 s5
Nan X, Tamgüney T, Collisson E, Lin L, Pitt C, Galeas J, et al. Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway. Proc Natl Acad Sci U S A. 2015;112:7996-8001 pubmed 出版商
  • 免疫印迹; 人类
Pastor Clerigues A, Martí Bonmatí E, Milara J, Almudever P, Cortijo J. Anti-inflammatory and anti-fibrotic profile of fish oil emulsions used in parenteral nutrition-associated liver disease. PLoS ONE. 2014;9:e115404 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Doughton G, Wei J, Tapon N, Welham M, Chalmers A. Formation of a polarised primitive endoderm layer in embryoid bodies requires fgfr/erk signalling. PLoS ONE. 2014;9:e95434 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:250; 图 3
Maier P, Zemoura K, Acu a M, Y venes G, Zeilhofer H, Benke D. Ischemia-like oxygen and glucose deprivation mediates down-regulation of cell surface ?-aminobutyric acidB receptors via the endoplasmic reticulum (ER) stress-induced transcription factor CCAAT/enhancer-binding protein (C/EBP)-homologous protein (CH. J Biol Chem. 2014;289:12896-907 pubmed 出版商
  • 免疫印迹; 人类
Chapnick D, Liu X. Leader cell positioning drives wound-directed collective migration in TGF?-stimulated epithelial sheets. Mol Biol Cell. 2014;25:1586-93 pubmed 出版商
  • reverse phase protein lysate microarray; 人类; 1:500
Milara J, Peiró T, Serrano A, Guijarro R, Zaragozá C, Tenor H, et al. Roflumilast N-oxide inhibits bronchial epithelial to mesenchymal transition induced by cigarette smoke in smokers with COPD. Pulm Pharmacol Ther. 2014;28:138-48 pubmed 出版商
Dunipace L, Akos Z, Stathopoulos A. Coacting enhancers can have complementary functions within gene regulatory networks and promote canalization. PLoS Genet. 2019;15:e1008525 pubmed 出版商
Liu B, Satou Y. Foxg specifies sensory neurons in the anterior neural plate border of the ascidian embryo. Nat Commun. 2019;10:4911 pubmed 出版商
Doll M, Soltanmohammadi N, Schumacher B. ALG-2/AGO-Dependent mir-35 Family Regulates DNA Damage-Induced Apoptosis Through MPK-1/ERK MAPK Signaling Downstream of the Core Apoptotic Machinery in Caenorhabditis elegans. Genetics. 2019;213:173-194 pubmed 出版商
Inamdar V, Reddy H, Dangelmaier C, Kostyak J, Kunapuli S. The protein tyrosine phosphatase PTPN7 is a negative regulator of ERK activation and thromboxane generation in platelets. J Biol Chem. 2019;294:12547-12554 pubmed 出版商
Samson S, Elliott A, Mueller B, Kim Y, Carney K, Bergman J, et al. p90 ribosomal S6 kinase (RSK) phosphorylates myosin phosphatase and thereby controls edge dynamics during cell migration. J Biol Chem. 2019;: pubmed 出版商
Kalfon R, Friedman T, Eliachar S, Shofti R, Haas T, Koren L, et al. JDP2 and ATF3 deficiencies dampen maladaptive cardiac remodeling and preserve cardiac function. PLoS ONE. 2019;14:e0213081 pubmed 出版商
Li Y, Peng R, Gao W, Liu P, Chen L, Zhang X, et al. The ubiquitin ligase KBTBD8 regulates PKM1 levels via Erk1/2 and Aurora A to ensure oocyte quality. Aging (Albany NY). 2019;11:1110-1128 pubmed 出版商
Iavarone C, Zervantonakis I, Selfors L, Palakurthi S, Liu J, Drapkin R, et al. Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness. Mol Cancer Ther. 2019;18:642-655 pubmed 出版商
Zhou Y, Popadowski S, Deutschman E, Halfon M. Distinct roles and requirements for Ras pathway signaling in visceral versus somatic muscle founder specification. Development. 2019;146: pubmed 出版商
Hey F, Andreadi C, Noble C, Patel B, Jin H, Kamata T, et al. Over-expressed, N-terminally truncated BRAF is detected in the nucleus of cells with nuclear phosphorylated MEK and ERK. Heliyon. 2018;4:e01065 pubmed 出版商
Milara J, Díaz Platas L, Contreras S, Ribera P, Roger I, Ballester B, et al. MUC1 deficiency mediates corticosteroid resistance in chronic obstructive pulmonary disease. Respir Res. 2018;19:226 pubmed 出版商
Tokuoka M, Kobayashi K, Satou Y. Distinct regulation of Snail in two muscle lineages of the ascidian embryo achieves temporal coordination of muscle development. Development. 2018;145: pubmed 出版商
Garner K, Voliotis M, Alobaid H, Perrett R, Pham T, Tsaneva Atanasova K, et al. Information Transfer via Gonadotropin-Releasing Hormone Receptors to ERK and NFAT: Sensing GnRH and Sensing Dynamics. J Endocr Soc. 2017;1:260-277 pubmed 出版商
Zhang X, Liu P, Yang Z, Zhao J, Gao L, Yuan B, et al. Pnma5 is essential to the progression of meiosis in mouse oocytes through a chain of phosphorylation. Oncotarget. 2017;8:96809-96825 pubmed 出版商
Zega K, Jovanovic V, Vitic Z, Niedzielska M, Knaapi L, Jukic M, et al. Dusp16 Deficiency Causes Congenital Obstructive Hydrocephalus and Brain Overgrowth by Expansion of the Neural Progenitor Pool. Front Mol Neurosci. 2017;10:372 pubmed 出版商
Jin T, Lavoie H, Sahmi M, David M, Hilt C, Hammell A, et al. RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition. Nat Commun. 2017;8:1211 pubmed 出版商
Wilson C, Nimick M, Nehoff H, Ashton J. ALK and IGF-1R as independent targets in crizotinib resistant lung cancer. Sci Rep. 2017;7:13955 pubmed 出版商
Wang Z, Zhang F, He J, Wu P, Tay L, Cai M, et al. Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells. Dev Cell. 2017;43:186-197.e7 pubmed 出版商
Bluemn E, Coleman I, Lucas J, Coleman R, Hernández López S, Tharakan R, et al. Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling. Cancer Cell. 2017;32:474-489.e6 pubmed 出版商
Bao H, Guo C, Qiu P, Zhang X, Dong Q, Wang Y. Long non-coding RNA Igf2as controls hepatocellular carcinoma progression through the ERK/MAPK signaling pathway. Oncol Lett. 2017;14:2831-2837 pubmed 出版商
Kalfon R, Haas T, Shofti R, Moskovitz J, Schwartz O, Suss Toby E, et al. c-Jun dimerization protein 2 (JDP2) deficiency promotes cardiac hypertrophy and dysfunction in response to pressure overload. Int J Cardiol. 2017;249:357-363 pubmed 出版商
Yoon D, Alfhili M, Friend K, Lee M. MPK-1/ERK regulatory network controls the number of sperm by regulating timing of sperm-oocyte switch in C. elegans germline. Biochem Biophys Res Commun. 2017;491:1077-1082 pubmed 出版商
Tang H, Han M. Fatty Acids Regulate Germline Sex Determination through ACS-4-Dependent Myristoylation. Cell. 2017;169:457-469.e13 pubmed 出版商
Altmüller F, Pothula S, Annamneedi A, Nakhaei Rad S, Montenegro Venegas C, Pina Fernández E, et al. Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy. PLoS Genet. 2017;13:e1006684 pubmed 出版商
Xiao X, Yang L, Pang X, Zhang R, Zhu Y, Wang P, et al. A Mesh-Duox pathway regulates homeostasis in the insect gut. Nat Microbiol. 2017;2:17020 pubmed 出版商
Kwon S, An S, Kim M, Kim K, Choi Y, Ahn K, et al. Phytosphingosine-1-phosphate and epidermal growth factor synergistically restore extracellular matrix in human dermal fibroblasts in vitro and in vivo. Int J Mol Med. 2017;39:741-748 pubmed 出版商
Davaapil H, Brockes J, Yun M. Conserved and novel functions of programmed cellular senescence during vertebrate development. Development. 2017;144:106-114 pubmed 出版商
Miao G, Hayashi S. Escargot controls the sequential specification of two tracheal tip cell types by suppressing FGF signaling in Drosophila. Development. 2016;143:4261-4271 pubmed
Lee J, Park S, Kim K, Ko J, Lee S, Kim K, et al. Novel Function of Sprouty4 as a Regulator of Stemness and Differentiation of Embryonic Stem Cells. Dev Reprod. 2016;20:171-7 pubmed 出版商
Milara J, Morell A, Ballester B, Armengot M, Morcillo E, Cortijo J. MUC4 impairs the anti-inflammatory effects of corticosteroids in patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2017;139:855-862.e13 pubmed 出版商
Abramovitch Dahan C, Asraf H, Bogdanovic M, Sekler I, Bush A, Hershfinkel M. Amyloid ? attenuates metabotropic zinc sensing receptor, mZnR/GPR39, dependent Ca2+ , ERK1/2 and Clusterin signaling in neurons. J Neurochem. 2016;139:221-233 pubmed 出版商
Li Q, Davila J, Kannan A, Flaws J, Bagchi M, Bagchi I. Chronic Exposure to Bisphenol A Affects Uterine Function During Early Pregnancy in Mice. Endocrinology. 2016;157:1764-74 pubmed 出版商
Stragier E, Martin V, Davenas E, Poilbout C, Mongeau R, Corradetti R, et al. Brain plasticity and cognitive functions after ethanol consumption in C57BL/6J mice. Transl Psychiatry. 2015;5:e696 pubmed 出版商
Schroter C, Rué P, Mackenzie J, Martinez Arias A. FGF/MAPK signaling sets the switching threshold of a bistable circuit controlling cell fate decisions in embryonic stem cells. Development. 2015;142:4205-16 pubmed 出版商
Bar Lev T, Harris D, Tomić M, Stojilkovic S, Blumenfeld Z, Brown P, et al. Role of PI4K and PI3K-AKT in ERK1/2 activation by GnRH in the pituitary gonadotropes. Mol Cell Endocrinol. 2015;415:12-23 pubmed 出版商
Maillard A, Ruef A, Pizzagalli F, Migliavacca E, Hippolyte L, Adaszewski S, et al. The 16p11.2 locus modulates brain structures common to autism, schizophrenia and obesity. Mol Psychiatry. 2015;20:140-7 pubmed 出版商
Lerner N, Beit Yannai E. Cross-talk between ciliary epithelium and trabecular meshwork cells in-vitro: a new insight into glaucoma. PLoS ONE. 2014;9:e112259 pubmed 出版商
Tsuzuki S, Matsumoto H, Furihata S, Ryuda M, Tanaka H, Sung E, et al. Switching between humoral and cellular immune responses in Drosophila is guided by the cytokine GBP. Nat Commun. 2014;5:4628 pubmed 出版商
Gonzalez Garcia J, Bradley J, Nomikos M, Paul L, Machaty Z, Lai F, et al. The dynamics of MAPK inactivation at fertilization in mouse eggs. J Cell Sci. 2014;127:2749-60 pubmed 出版商
Leibovich Rivkin T, Liubomirski Y, Meshel T, Abashidze A, Brisker D, Solomon H, et al. The inflammatory cytokine TNF? cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells. BMC Cancer. 2014;14:158 pubmed 出版商
Eberhard R, Stergiou L, Hofmann E, Hofmann J, Haenni S, Teo Y, et al. Ribosome synthesis and MAPK activity modulate ionizing radiation-induced germ cell apoptosis in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003943 pubmed 出版商
Ohta N, Satou Y. Multiple signaling pathways coordinate to induce a threshold response in a chordate embryo. PLoS Genet. 2013;9:e1003818 pubmed 出版商
Haupaix N, Stolfi A, Sirour C, Picco V, Levine M, Christiaen L, et al. p120RasGAP mediates ephrin/Eph-dependent attenuation of FGF/ERK signals during cell fate specification in ascidian embryos. Development. 2013;140:4347-52 pubmed 出版商
Bickel R, Cleveland H, Barkas J, Jeschke C, Raz A, Stern D, et al. The pea aphid uses a version of the terminal system during oviparous, but not viviparous, development. Evodevo. 2013;4:10 pubmed 出版商
Bluemn E, Spencer E, Mecham B, Gordon R, Coleman I, Lewinshtein D, et al. PPP2R2C loss promotes castration-resistance and is associated with increased prostate cancer-specific mortality. Mol Cancer Res. 2013;11:568-78 pubmed 出版商
Norton J, Cooley J, Islam A, Cota C, Davidson B. Matrix adhesion polarizes heart progenitor induction in the invertebrate chordate Ciona intestinalis. Development. 2013;140:1301-11 pubmed 出版商
Shi L, Ko M, Abbott L, Ko G. Identification of Peptide lv, a novel putative neuropeptide that regulates the expression of L-type voltage-gated calcium channels in photoreceptors. PLoS ONE. 2012;7:e43091 pubmed 出版商
Wagner E, Levine M. FGF signaling establishes the anterior border of the Ciona neural tube. Development. 2012;139:2351-9 pubmed 出版商
Kohno M, Tanimura S, Ozaki K. Targeting the extracellular signal-regulated kinase pathway in cancer therapy. Biol Pharm Bull. 2011;34:1781-4 pubmed
Stolfi A, Wagner E, Taliaferro J, Chou S, Levine M. Neural tube patterning by Ephrin, FGF and Notch signaling relays. Development. 2011;138:5429-39 pubmed 出版商
Cheng S, Yin P, Hsu Y, Chang Y, Huang S, Lee J, et al. Leptin enhances migration of human papillary thyroid cancer cells through the PI3K/AKT and MEK/ERK signaling pathways. Oncol Rep. 2011;26:1265-71 pubmed 出版商
Jung J, Moon S, Kim D, Choi C, Song J, Park K. Sprouty1 regulates neural and endothelial differentiation of mouse embryonic stem cells. Stem Cells Dev. 2012;21:554-61 pubmed 出版商
Prabakaran S, Everley R, Landrieu I, Wieruszeski J, Lippens G, Steen H, et al. Comparative analysis of Erk phosphorylation suggests a mixed strategy for measuring phospho-form distributions. Mol Syst Biol. 2011;7:482 pubmed 出版商
Steelman L, Chappell W, Abrams S, Kempf R, Long J, Laidler P, et al. Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. Aging (Albany NY). 2011;3:192-222 pubmed
Stark F, Pfannstiel J, Klaiber I, Raabe T. Protein kinase CK2 links polyamine metabolism to MAPK signalling in Drosophila. Cell Signal. 2011;23:876-82 pubmed 出版商
Hasin T, Elhanani O, Abassi Z, Hai T, Aronheim A. Angiotensin II signaling up-regulates the immediate early transcription factor ATF3 in the left but not the right atrium. Basic Res Cardiol. 2011;106:175-87 pubmed 出版商
Guidi M, Muiños Gimeno M, Kagerbauer B, Marti E, Estivill X, Espinosa Parrilla Y. Overexpression of miR-128 specifically inhibits the truncated isoform of NTRK3 and upregulates BCL2 in SH-SY5Y neuroblastoma cells. BMC Mol Biol. 2010;11:95 pubmed 出版商
Sugden P, Markou T, Fuller S, Tham E, Molkentin J, Paterson H, et al. Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active. Cell Signal. 2011;23:468-77 pubmed 出版商
Burkhard K, Shapiro P. Use of inhibitors in the study of MAP kinases. Methods Mol Biol. 2010;661:107-22 pubmed 出版商
Heger P, Kroiher M, Ndifon N, Schierenberg E. Conservation of MAP kinase activity and MSP genes in parthenogenetic nematodes. BMC Dev Biol. 2010;10:51 pubmed 出版商
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Hoffman G, Moerke N, Hsia M, Shamu C, Blenis J. A high-throughput, cell-based screening method for siRNA and small molecule inhibitors of mTORC1 signaling using the In Cell Western technique. Assay Drug Dev Technol. 2010;8:186-99 pubmed 出版商
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Reischauer S, Levesque M, NUSSLEIN VOLHARD C, Sonawane M. Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis. PLoS Genet. 2009;5:e1000720 pubmed 出版商
Chen P, Simons M, Friesel R. FRS2 via fibroblast growth factor receptor 1 is required for platelet-derived growth factor receptor beta-mediated regulation of vascular smooth muscle marker gene expression. J Biol Chem. 2009;284:15980-92 pubmed 出版商
Shi W, Levine M. Ephrin signaling establishes asymmetric cell fates in an endomesoderm lineage of the Ciona embryo. Development. 2008;135:931-40 pubmed 出版商
Le X, Langenau D, Keefe M, Kutok J, Neuberg D, Zon L. Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish. Proc Natl Acad Sci U S A. 2007;104:9410-5 pubmed
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Product No. :
产品名称 :
Anti-MAP Kinase, Activated (Diphosphorylated ERK-1&2) antibody, Mouse monoclonal
宿主 :
共轭标签 :
抗体类型 :
Clone Number (if monoclonal) :
应用/描述 :
Suitable for immunocytochemistry; western blot: 0.5-1 μg/mL using a whole cell extract of RAT-1 cells treated with vanadate and H 2 O 2 .; microarray; indirect ELISA; immunoprecipitation (IP); immunohistochemistry
物种活性 :
小鼠, 蛙, 果蝇, 秀丽隐杆线虫, 大鼠, 酵母, 仓鼠, 牛, 人类
抗体亚型 :
浓度 :
1.5-2 mg/毫升
储存 :
更多信息或购买 :
800-819-3336 400-620-3333 86-21-6141 5566
公司总部: 美国