产品简要
公司名称 :
西格玛奥德里奇
其他品牌 :
FLUKA, Sigma-Aldrich, Roche Applied Science
产品类型 :
抗体
产品名称 :
Anti-Parkin antibody, Mouse monoclonal
目录 :
P6248
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
PRK8
反应物种 :
African green monkey, 人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
文章摘录数: 23
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 人类; 图 6
  • 免疫印迹; 人类; 1:2000; 图 7
Okatsu K, Koyano F, Kimura M, Kosako H, Saeki Y, Tanaka K, et al. Phosphorylated ubiquitin chain is the genuine Parkin receptor. J Cell Biol. 2015;209:111-28 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 3b
  • 免疫印迹; 小鼠; 图 2c
Corsetti V, Florenzano F, Atlante A, Bobba A, Ciotti M, Natale F, et al. NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease. Hum Mol Genet. 2015;24:3058-81 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 1
Zhang C, Lee S, Peng Y, Bunker E, Shen C, Giaime E, et al. A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics. Cell Res. 2015;25:394-7 pubmed 出版商
  • 免疫沉淀; 人类; 1:6000; 图 2
  • 免疫印迹; 人类; 1:6000; 图 2
  • 免疫沉淀; 小鼠; 1:6000; 图 2
  • 免疫印迹; 小鼠; 1:6000; 图 2
Maraschi A, Ciammola A, Folci A, Sassone F, Ronzitti G, Cappelletti G, et al. Parkin regulates kainate receptors by interacting with the GluK2 subunit. Nat Commun. 2014;5:5182 pubmed 出版商
  • 免疫印迹; 人类; 1:2000
Koyano F, Okatsu K, Kosako H, Tamura Y, Go E, Kimura M, et al. Ubiquitin is phosphorylated by PINK1 to activate parkin. Nature. 2014;510:162-6 pubmed 出版商
  • 免疫细胞化学; African green monkey
  • 免疫印迹; 小鼠
Brot S, Auger C, Bentata R, Rogemond V, Ménigoz S, Chounlamountri N, et al. Collapsin response mediator protein 5 (CRMP5) induces mitophagy, thereby regulating mitochondrion numbers in dendrites. J Biol Chem. 2014;289:2261-76 pubmed 出版商
Okatsu K, Sato Y, Yamano K, Matsuda N, Negishi L, Takahashi A, et al. Structural insights into ubiquitin phosphorylation by PINK1. Sci Rep. 2018;8:10382 pubmed 出版商
Gouspillou G, Godin R, Piquereau J, Picard M, Mofarrahi M, Mathew J, et al. Protective role of Parkin in skeletal muscle contractile and mitochondrial function. J Physiol. 2018;596:2565-2579 pubmed 出版商
Callegari S, Oeljeklaus S, Warscheid B, Dennerlein S, Thumm M, Rehling P, et al. Phospho-ubiquitin-PARK2 complex as a marker for mitophagy defects. Autophagy. 2017;13:201-211 pubmed 出版商
Tang J, Hu Z, Tan J, Yang S, Zeng L. Parkin Protects against Oxygen-Glucose Deprivation/Reperfusion Insult by Promoting Drp1 Degradation. Oxid Med Cell Longev. 2016;2016:8474303 pubmed 出版商
Aversa Z, Pin F, Lucia S, Penna F, Verzaro R, Fazi M, et al. Autophagy is induced in the skeletal muscle of cachectic cancer patients. Sci Rep. 2016;6:30340 pubmed 出版商
Yamano K, Queliconi B, Koyano F, Saeki Y, Hirokawa T, Tanaka K, et al. Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation. J Biol Chem. 2015;290:25199-211 pubmed 出版商
Okatsu K, Kimura M, Oka T, Tanaka K, Matsuda N. Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment. J Cell Sci. 2015;128:964-78 pubmed 出版商
Ishihara T, Ban Ishihara R, Maeda M, Matsunaga Y, Ichimura A, Kyogoku S, et al. Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development. Mol Cell Biol. 2015;35:211-23 pubmed 出版商
Piquereau J, Godin R, Deschênes S, Bessi V, Mofarrahi M, Hussain S, et al. Protective role of PARK2/Parkin in sepsis-induced cardiac contractile and mitochondrial dysfunction. Autophagy. 2013;9:1837-51 pubmed 出版商
Koyano F, Okatsu K, Ishigaki S, Fujioka Y, Kimura M, Sobue G, et al. The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons. Genes Cells. 2013;18:672-81 pubmed 出版商
Okatsu K, Oka T, Iguchi M, Imamura K, Kosako H, Tani N, et al. PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria. Nat Commun. 2012;3:1016 pubmed 出版商
Fett M, Pilsl A, Paquet D, van Bebber F, Haass C, Tatzelt J, et al. Parkin is protective against proteotoxic stress in a transgenic zebrafish model. PLoS ONE. 2010;5:e11783 pubmed 出版商
Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, Gautier C, et al. PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol. 2010;189:211-21 pubmed 出版商
Pawlyk A, Giasson B, Sampathu D, Perez F, Lim K, Dawson V, et al. Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age. J Biol Chem. 2003;278:48120-8 pubmed
Imai Y, Soda M, Takahashi R. Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity. J Biol Chem. 2000;275:35661-4 pubmed
Gu W, Abbas N, Lagunes M, Parent A, Pradier L, Bohme G, et al. Cloning of rat parkin cDNA and distribution of parkin in rat brain. J Neurochem. 2000;74:1773-6 pubmed
Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature. 1998;392:605-8 pubmed
产品信息
Product No. :
P6248
产品名称 :
Anti-Parkin antibody, Mouse monoclonal
宿主 :
小鼠
共轭标签 :
未共轭
抗体类型 :
单克隆
Clone Number (if monoclonal) :
PRK8
应用/描述 :
Suitable for microarray; western blot: 0.25-0.5 μg/mL using using rat brain cytosolic S1 extract
物种活性 :
人类, 仓鼠, 小鼠, 大鼠
抗体亚型 :
IgG2b
浓度 :
~2 mg/毫升
储存 :
存放在-20°C
更多信息或购买 :
公司信息
西格玛奥德里奇
上海市徐汇区淮海中路1010号嘉华中心41楼
techservCN@sial.com
http://www.sigmaaldrich.com/china-mainland.html
800-819-3336 400-620-3333 86-21-6141 5566
公司总部: 美国
Sigma-Aldrich是一家在生命科学领域领先的且拥有高科技产品的公司,致力于为生命科学、制药化工等领域提供高质量的服务和产品。