产品简要
公司名称 :
西格玛奥德里奇
其他品牌 :
FLUKA, Sigma-Aldrich, Roche Applied Science
产品类型 :
抗体
产品名称 :
抗p53抗体, 小鼠单克隆
目录 :
P6874
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
DO-1
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫沉淀, 染色质免疫沉淀 , ChIP-Seq, 核糖核酸免疫沉淀
更多信息或购买 :
文章摘录数: 65
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 6d
  • 核糖核酸免疫沉淀; 人类; 图 3b
  • ChIP-Seq; 人类; 图 1a
  • 免疫沉淀; 人类; 图 3d
  • 免疫印迹; 人类; 图 1d
Schmitt A, Garcia J, Hung T, Flynn R, Shen Y, Qu K, et al. An inducible long noncoding RNA amplifies DNA damage signaling. Nat Genet. 2016;48:1370-1376 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2
Shang R, Zhang F, Xu B, Xi H, Zhang X, Wang W, et al. Ribozyme-enhanced single-stranded Ago2-processed interfering RNA triggers efficient gene silencing with fewer off-target effects. Nat Commun. 2015;6:8430 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 2
  • 免疫印迹; 人类; 图 1
Kirschner K, Samarajiwa S, Cairns J, Menon S, Perez Mancera P, Tomimatsu K, et al. Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53. PLoS Genet. 2015;11:e1005053 pubmed 出版商
McDonnell S, Spiller D, White M, Prior I, Paraoan L. ER stress-linked autophagy stabilizes apoptosis effector PERP and triggers its co-localization with SERCA2b at ER-plasma membrane junctions. Cell Death Discov. 2019;5:132 pubmed 出版商
Steels A, Vannevel L, Zwaenepoel O, Gettemans J. Nb-induced stabilisation of p53 in HPV-infected cells. Sci Rep. 2019;9:12680 pubmed 出版商
Miao H, Wang L, Zhan H, Dai J, Chang Y, Wu F, et al. A long noncoding RNA distributed in both nucleus and cytoplasm operates in the PYCARD-regulated apoptosis by coordinating the epigenetic and translational regulation. PLoS Genet. 2019;15:e1008144 pubmed 出版商
Chen H, Huang H, Zhao J, Wang Z, Chang M, Xue L, et al. Age-dependent copy number variations of TP53 tumour suppressor gene associated with altered phosphorylation status of p53 protein in sporadic schwannomas. J Neurooncol. 2019;143:369-379 pubmed 出版商
Chen H, Xue L, Huang H, Wang H, Zhang X, Zhu W, et al. Synergistic effect of Nutlin-3 combined with MG-132 on schwannoma cells through restoration of merlin and p53 tumour suppressors. EBioMedicine. 2018;36:252-265 pubmed 出版商
Yusenko M, Jakobs A, Klempnauer K. A novel cell-based screening assay for small-molecule MYB inhibitors identifies podophyllotoxins teniposide and etoposide as inhibitors of MYB activity. Sci Rep. 2018;8:13159 pubmed 出版商
Wiesmann N, Strozynski J, Beck C, Zimmermann N, Mendler S, Gieringer R, et al. Knockdown of hnRNPK leads to increased DNA damage after irradiation and reduces survival of tumor cells. Carcinogenesis. 2017;38:321-328 pubmed 出版商
Rizzo A, Iachettini S, Salvati E, Zizza P, Maresca C, D Angelo C, et al. SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage. Nucleic Acids Res. 2017;45:1820-1834 pubmed 出版商
Pfister N, Fomin V, Regunath K, Zhou J, Zhou W, Silwal Pandit L, et al. Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells. Genes Dev. 2015;29:1298-315 pubmed 出版商
Minamino M, Oka T, Kanouchi H. Growth suppression and cell death by pyridoxal is dependent on p53 in the human breast cancer cell line MCF-7. Biosci Biotechnol Biochem. 2015;79:124-9 pubmed 出版商
Cook G, Caudell D, Elford H, Pardee T. The efficacy of the ribonucleotide reductase inhibitor Didox in preclinical models of AML. PLoS ONE. 2014;9:e112619 pubmed 出版商
Xie D, Lan L, Huang K, Chen L, Xu C, Wang R, et al. Association of p53/p21 expression and cigarette smoking with tumor progression and poor prognosis in non-small cell lung cancer patients. Oncol Rep. 2014;32:2517-26 pubmed 出版商
Yu H, Yue X, Zhao Y, Li X, Wu L, Zhang C, et al. LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers. Nat Commun. 2014;5:5218 pubmed 出版商
Mohamed M, Mohamed M, Fathi M, Shouman S, Abdelhamid I. Chalcones incorporated pyrazole ring inhibit proliferation, cell cycle progression, angiogenesis and induce apoptosis of MCF7 cell line. Anticancer Agents Med Chem. 2014;14:1282-92 pubmed
Sun Y, Chen C, Zhang P, Xie H, Hou L, Hui Z, et al. Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway. Sci Rep. 2014;4:6527 pubmed 出版商
Ivanov V, Hei T. Radiation-induced glioblastoma signaling cascade regulates viability, apoptosis and differentiation of neural stem cells (NSC). Apoptosis. 2014;19:1736-54 pubmed 出版商
Jiao F, Hu H, Yuan C, Wang L, Jiang W, Jin Z, et al. Elevated expression level of long noncoding RNA MALAT-1 facilitates cell growth, migration and invasion in pancreatic cancer. Oncol Rep. 2014;32:2485-92 pubmed 出版商
Vizioli M, Santos J, Pilotti S, Mazzoni M, Anania M, Miranda C, et al. Oncogenic RAS-induced senescence in human primary thyrocytes: molecular effectors and inflammatory secretome involved. Oncotarget. 2014;5:8270-83 pubmed
Williams R, Hubberstey A. Benzo(a)pyrene exposure causes adaptive changes in p53 and CYP1A gene expression in Brown bullhead (Ameiurus nebulosus). Aquat Toxicol. 2014;156:201-10 pubmed 出版商
van der Ent W, Burrello C, Teunisse A, Ksander B, van der Velden P, Jager M, et al. Modeling of human uveal melanoma in zebrafish xenograft embryos. Invest Ophthalmol Vis Sci. 2014;55:6612-22 pubmed 出版商
Ma Y, Gong Y, Cheng Z, Loganathan S, Kao C, Sarkaria J, et al. Critical functions of RhoB in support of glioblastoma tumorigenesis. Neuro Oncol. 2015;17:516-25 pubmed 出版商
Murao K, Yoshioka R, Kubo Y. Human papillomavirus infection in Bowen disease: negative p53 expression, not p16(INK4a) overexpression, is correlated with human papillomavirus-associated Bowen disease. J Dermatol. 2014;41:878-84 pubmed 出版商
Chen H, Guo S, Li Z, Lu Y, Jiang D, Zhang R, et al. A critical role for interferon regulatory factor 9 in cerebral ischemic stroke. J Neurosci. 2014;34:11897-912 pubmed 出版商
Forini F, Kusmic C, Nicolini G, Mariani L, Zucchi R, Matteucci M, et al. Triiodothyronine prevents cardiac ischemia/reperfusion mitochondrial impairment and cell loss by regulating miR30a/p53 axis. Endocrinology. 2014;155:4581-90 pubmed 出版商
Raoof M, Zhu C, Cisneros B, Liu H, Corr S, Wilson L, et al. Hyperthermia inhibits recombination repair of gemcitabine-stalled replication forks. J Natl Cancer Inst. 2014;106: pubmed 出版商
Tomicic M, Aasland D, Naumann S, Meise R, Barckhausen C, Kaina B, et al. Translesion polymerase ? is upregulated by cancer therapeutics and confers anticancer drug resistance. Cancer Res. 2014;74:5585-96 pubmed 出版商
Xin Y, Zhang H, Tang T, Liu G, Wang J, Jiang G, et al. Low‑dose radiation‑induced apoptosis in human leukemia K562 cells through mitochondrial pathways. Mol Med Rep. 2014;10:1569-75 pubmed 出版商
Okadome M, Saito T, Nishiyama N, Ariyoshi K, Shimamoto K, Shimada T, et al. Prediction of histological types of endometrial cancer by endometrial cytology. J Obstet Gynaecol Res. 2014;40:1931-9 pubmed 出版商
Yamaguchi T, Ikehara S, Nakanishi H, Ikehara Y. A genetically engineered mouse model developing rapid progressive pancreatic ductal adenocarcinoma. J Pathol. 2014;234:228-38 pubmed 出版商
Su L, Zheng H, Li Z, Qiu J, Chen S, Liu J, et al. Mechanistic studies on the anticancer activity of 2,4-disubstituted quinazoline derivative. Biochim Biophys Acta. 2014;1840:3123-30 pubmed 出版商
van der Ent W, Jochemsen A, Teunisse A, Krens S, Szuhai K, Spaink H, et al. Ewing sarcoma inhibition by disruption of EWSR1-FLI1 transcriptional activity and reactivation of p53. J Pathol. 2014;233:415-24 pubmed 出版商
Pardee T, Stadelman K, Jennings Gee J, Caudell D, Gmeiner W. The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cells. Oncotarget. 2014;5:4170-9 pubmed
Mylona E, Melissaris S, Nomikos A, Theohari I, Giannopoulou I, Tzelepis K, et al. Effect of BRCA1 immunohistochemical localizations on prognosis of patients with sporadic breast carcinomas. Pathol Res Pract. 2014;210:533-40 pubmed 出版商
Yeh C, Yen C, Chen Y, Cheng C, Huang S, Chang T, et al. Identification of aurora kinase A as an unfavorable prognostic factor and potential treatment target for metastatic gastrointestinal stromal tumors. Oncotarget. 2014;5:4071-86 pubmed
Shoji K, Teishima J, Hayashi T, Ohara S, McKeehan W, Matsubara A. Restoration of fibroblast growth factor receptor 2IIIb enhances the chemosensitivity of human prostate cancer cells. Oncol Rep. 2014;32:65-70 pubmed 出版商
van Miltenburg M, van Nimwegen M, Tijdens I, Lalai R, Kuiper R, Klarenbeek S, et al. Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation. Br J Cancer. 2014;110:2747-55 pubmed 出版商
Iqbal N, Xu L, Devitt C, Skapek S. Isolation and characterization of mammalian cells expressing the Arf promoter during eye development. Biotechniques. 2014;56:239-49 pubmed 出版商
Kitamura Y, Ito M, Matsuo T, Boda T, Oka S, Yoshihara M, et al. Characteristic epithelium with low-grade atypia appears on the surface of gastric cancer after successful Helicobacter pylori eradication therapy. Helicobacter. 2014;19:289-95 pubmed 出版商
Guo X, Sesaki H, Qi X. Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo. Biochem J. 2014;461:137-46 pubmed 出版商
Bohanon F, Wang X, Ding C, Ding Y, Radhakrishnan G, Rastellini C, et al. Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis. J Surg Res. 2014;190:55-63 pubmed 出版商
Ke R, Wang Y, Mao Y, Zhang J, Xiong J. Decreased expression of LASS2 is associated with worse prognosis in meningiomas. J Neurooncol. 2014;118:369-376 pubmed 出版商
Yu Z, Xu Z, Disante G, Wright J, Wang M, Li Y, et al. miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1. Oncotarget. 2014;5:1083-90 pubmed
Sin T, Yu A, Yung B, Yip S, Chan L, Wong C, et al. Modulating effect of SIRT1 activation induced by resveratrol on Foxo1-associated apoptotic signalling in senescent heart. J Physiol. 2014;592:2535-48 pubmed 出版商
Li Q, Zhang Y, El Naggar A, Xiong S, Yang P, Jackson J, et al. Therapeutic efficacy of p53 restoration in Mdm2-overexpressing tumors. Mol Cancer Res. 2014;12:901-11 pubmed 出版商
Laget S, Miotto B, Chin H, Esteve P, Roberts R, Pradhan S, et al. MBD4 cooperates with DNMT1 to mediate methyl-DNA repression and protects mammalian cells from oxidative stress. Epigenetics. 2014;9:546-56 pubmed 出版商
Barbieri E, De Preter K, Capasso M, Chen Z, Hsu D, Tonini G, et al. Histone chaperone CHAF1A inhibits differentiation and promotes aggressive neuroblastoma. Cancer Res. 2014;74:765-74 pubmed 出版商
Karabulut S, Demiroglu Zergeroglu A, Yilmaz E, Sagir F, Delikara N. p53 and mitogen-activated protein kinase pathway protein profiles in fresh and frozen spermatozoa. Andrologia. 2014;46:1113-7 pubmed 出版商
Park H, Park J, Park S, Cho J, Kim S, Park B. Subcellular localization of Mdm2 expression and prognosis of breast cancer. Int J Clin Oncol. 2014;19:842-51 pubmed 出版商
Benbrook D, Nammalwar B, Long A, Matsumoto H, Singh A, Bunce R, et al. SHetA2 interference with mortalin binding to p66shc and p53 identified using drug-conjugated magnetic microspheres. Invest New Drugs. 2014;32:412-23 pubmed 出版商
Leufke C, Leykauf J, Krunic D, Jauch A, Holtgreve Grez H, Böhm Steuer B, et al. The telomere profile distinguishes two classes of genetically distinct cutaneous squamous cell carcinomas. Oncogene. 2014;33:3506-18 pubmed 出版商
Sangar F, Schreurs A, Umana Diaz C, Claperon A, Desbois Mouthon C, Calmel C, et al. Involvement of small ArfGAP1 (SMAP1), a novel Arf6-specific GTPase-activating protein, in microsatellite instability oncogenesis. Oncogene. 2014;33:2758-67 pubmed 出版商
You B, Park W. Zebularine inhibits the growth of A549 lung cancer cells via cell cycle arrest and apoptosis. Mol Carcinog. 2014;53:847-57 pubmed 出版商
Wedeken L, Singh P, Klempnauer K. Tumor suppressor protein Pdcd4 inhibits translation of p53 mRNA. J Biol Chem. 2011;286:42855-62 pubmed 出版商
Ng K, Ebrahem Q, Negrotto S, Mahfouz R, Link K, Hu Z, et al. p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia. Leukemia. 2011;25:1739-50 pubmed 出版商
Vilas Zornoza A, Agirre X, Martín Palanco V, Martin Subero J, San Jose Eneriz E, Garate L, et al. Frequent and simultaneous epigenetic inactivation of TP53 pathway genes in acute lymphoblastic leukemia. PLoS ONE. 2011;6:e17012 pubmed 出版商
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Yu W, Qiu Z, Gao N, Wang L, Cui H, Qian Y, et al. PAK1IP1, a ribosomal stress-induced nucleolar protein, regulates cell proliferation via the p53-MDM2 loop. Nucleic Acids Res. 2011;39:2234-48 pubmed 出版商
Lindström M, Nister M. Silencing of ribosomal protein S9 elicits a multitude of cellular responses inhibiting the growth of cancer cells subsequent to p53 activation. PLoS ONE. 2010;5:e9578 pubmed 出版商
Hubbard K, Catalano J, Puri R, Gnatt A. Knockdown of TFIIS by RNA silencing inhibits cancer cell proliferation and induces apoptosis. BMC Cancer. 2008;8:133 pubmed 出版商
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产品信息
目录代码 :
P6874
产品名称 :
抗p53抗体, 小鼠单克隆
产品类型 :
ANTIBODIES - SIAL
Product Group :
蛋白&通路技术
克隆性 :
单克隆
共轭 :
未共轭
克隆名称 :
DO-1
抗体亚型 :
IgG2a
产品描述 :
克隆DO-1, 纯化来自杂交瘤细胞细胞培养
更多信息或购买 :
公司信息
西格玛奥德里奇
上海市徐汇区淮海中路1010号嘉华中心41楼
techservCN@sial.com
http://www.sigmaaldrich.com/china-mainland.html
800-819-3336 400-620-3333 86-21-6141 5566
公司总部: 美国
Sigma-Aldrich是一家在生命科学领域领先的且拥有高科技产品的公司,致力于为生命科学、制药化工等领域提供高质量的服务和产品。