产品简要
公司名称 :
西格玛奥德里奇
其他品牌 :
FLUKA, Sigma-Aldrich, Roche Applied Science
产品类型 :
抗体
产品名称 :
Anti-α-Synuclein antibody, Mouse monoclonal
目录 :
S5566
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
syn211
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
文章摘录数: 30
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 小鼠; 1:1000; 图 2
Feng L, Federoff H, Vicini S, Maguire Zeiss K. Alpha-synuclein mediates alterations in membrane conductance: a potential role for alpha-synuclein oligomers in cell vulnerability. Eur J Neurosci. 2010;32:10-7 pubmed 出版商
Cariulo C, Martufi P, Verani M, Azzollini L, Bruni G, Weiss A, et al. Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay. Front Neurosci. 2019;13:889 pubmed 出版商
Anisimov S, Takahashi M, Kakihana T, Katsuragi Y, Kitaura H, Zhang L, et al. G3BP1 inhibits ubiquitinated protein aggregations induced by p62 and USP10. Sci Rep. 2019;9:12896 pubmed 出版商
Hu D, Niu J, Xiong J, Nie S, Zeng F, Zhang Z. LRRK2 G2019S Mutation Inhibits Degradation of α-Synuclein in an In Vitro Model of Parkinson's Disease. Curr Med Sci. 2018;38:1012-1017 pubmed 出版商
Takahashi M, Kitaura H, Kakita A, Kakihana T, Katsuragi Y, Nameta M, et al. USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis. iScience. 2018;9:433-450 pubmed 出版商
Ugras S, Daniels M, Fazelinia H, Gould N, Yocum A, Luk K, et al. Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders. EBioMedicine. 2018;31:307-319 pubmed 出版商
Kim D, Hwang H, Choi S, Kwon S, Lee S, Park J, et al. D409H GBA1 mutation accelerates the progression of pathology in A53T α-synuclein transgenic mouse model. Acta Neuropathol Commun. 2018;6:32 pubmed 出版商
Sethi R, Tripathi N, Pallapati A, Gaikar A, Bharatam P, Roy I. Does N-terminal huntingtin function as a 'holdase' for inhibiting cellular protein aggregation?. FEBS J. 2018;285:1791-1811 pubmed 出版商
Morabito G, Giannelli S, Ordazzo G, Bido S, Castoldi V, Indrigo M, et al. AAV-PHP.B-Mediated Global-Scale Expression in the Mouse Nervous System Enables GBA1 Gene Therapy for Wide Protection from Synucleinopathy. Mol Ther. 2017;25:2727-2742 pubmed 出版商
Cox D, Ecroyd H. The small heat shock proteins αB-crystallin (HSPB5) and Hsp27 (HSPB1) inhibit the intracellular aggregation of α-synuclein. Cell Stress Chaperones. 2017;22:589-600 pubmed 出版商
Pierdominici M, Maselli A, Cecchetti S, Tinari A, Mastrofrancesco A, Alfè M, et al. Diesel exhaust particle exposure in vitro impacts T lymphocyte phenotype and function. Part Fibre Toxicol. 2014;11:74 pubmed 出版商
Fernandez E, García Moreno J, Martín de Pablos A, Chacon J. May the thyroid gland and thyroperoxidase participate in nitrosylation of serum proteins and sporadic Parkinson's disease?. Antioxid Redox Signal. 2014;21:2143-8 pubmed 出版商
Overk C, Cartier A, Shaked G, Rockenstein E, Ubhi K, Spencer B, et al. Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies. Mol Neurodegener. 2014;9:18 pubmed 出版商
Colasanti T, Vomero M, Alessandri C, Barbati C, Maselli A, Camperio C, et al. Role of alpha-synuclein in autophagy modulation of primary human T lymphocytes. Cell Death Dis. 2014;5:e1265 pubmed 出版商
Sugeno N, Hasegawa T, Tanaka N, Fukuda M, Wakabayashi K, Oshima R, et al. Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized ?-synuclein. J Biol Chem. 2014;289:18137-51 pubmed 出版商
Rockenstein E, Nuber S, Overk C, Ubhi K, Mante M, Patrick C, et al. Accumulation of oligomer-prone ?-synuclein exacerbates synaptic and neuronal degeneration in vivo. Brain. 2014;137:1496-513 pubmed 出版商
Gelpi E, Navarro Otano J, Tolosa E, Gaig C, Compta Y, Rey M, et al. Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders. Mov Disord. 2014;29:1010-8 pubmed 出版商
B ttner S, Habernig L, Broeskamp F, Ruli D, V gtle F, Vlachos M, et al. Endonuclease G mediates ?-synuclein cytotoxicity during Parkinson's disease. EMBO J. 2013;32:3041-54 pubmed 出版商
Marxreiter F, Ettle B, May V, Esmer H, Patrick C, Kragh C, et al. Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice. Neurobiol Dis. 2013;59:38-51 pubmed 出版商
Koehler N, Stransky E, Shing M, Gaertner S, Meyer M, Schreitmüller B, et al. Altered serum IgG levels to α-synuclein in dementia with Lewy bodies and Alzheimer's disease. PLoS ONE. 2013;8:e64649 pubmed 出版商
Harms A, Cao S, Rowse A, Thome A, Li X, Mangieri L, et al. MHCII is required for ?-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration. J Neurosci. 2013;33:9592-600 pubmed 出版商
Fernandez E, García Moreno J, Martín de Pablos A, Chacon J. May the evaluation of nitrosative stress through selective increase of 3-nitrotyrosine proteins other than nitroalbumin and dominant tyrosine-125/136 nitrosylation of serum α-synuclein serve for diagnosis of sporadic Parkinson's disease?. Antioxid Redox Signal. 2013;19:912-8 pubmed 出版商
Cartier A, Ubhi K, Spencer B, Vázquez Roque R, Kosberg K, Fourgeaud L, et al. Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy. PLoS ONE. 2012;7:e34713 pubmed 出版商
Prasad K, Beach T, Hedreen J, Richfield E. Critical role of truncated ?-synuclein and aggregates in Parkinson's disease and incidental Lewy body disease. Brain Pathol. 2012;22:811-25 pubmed 出版商
Malkus K, Ischiropoulos H. Regional deficiencies in chaperone-mediated autophagy underlie ?-synuclein aggregation and neurodegeneration. Neurobiol Dis. 2012;46:732-44 pubmed 出版商
Olah J, Vincze O, Virok D, Simon D, Bozso Z, Tökési N, et al. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. J Biol Chem. 2011;286:34088-100 pubmed 出版商
Ubhi K, Rockenstein E, Mante M, Inglis C, Adame A, Patrick C, et al. Alpha-synuclein deficient mice are resistant to toxin-induced multiple system atrophy. Neuroreport. 2010;21:457-62 pubmed 出版商
Crews L, Spencer B, Desplats P, Patrick C, Paulino A, Rockenstein E, et al. Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. PLoS ONE. 2010;5:e9313 pubmed 出版商
Martin L, Pan Y, Price A, Sterling W, Copeland N, Jenkins N, et al. Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J Neurosci. 2006;26:41-50 pubmed
Giasson B, Jakes R, Goedert M, Duda J, Leight S, Trojanowski J, et al. A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease. J Neurosci Res. 2000;59:528-33 pubmed
产品信息
Product No. :
S5566
产品名称 :
Anti-α-Synuclein antibody, Mouse monoclonal
宿主 :
小鼠
共轭标签 :
未共轭
抗体类型 :
单克隆
Clone Number (if monoclonal) :
Syn211
应用/描述 :
Suitable for immunohistochemistry; western blot: 0.25 μg/mL using recombinant human α·-synuclein.; immunoprecipitation (IP)
物种活性 :
mouse, rat human, zebra finch
抗体亚型 :
IgG1
浓度 :
~1 mg/毫升
储存 :
存放在-20°C
更多信息或购买 :
公司信息
西格玛奥德里奇
上海市徐汇区淮海中路1010号嘉华中心41楼
techservCN@sial.com
http://www.sigmaaldrich.com/china-mainland.html
800-819-3336 400-620-3333 86-21-6141 5566
公司总部: 美国
Sigma-Aldrich是一家在生命科学领域领先的且拥有高科技产品的公司,致力于为生命科学、制药化工等领域提供高质量的服务和产品。