产品简要
公司名称 :
美天旎
产品类型 :
抗体
产品名称 :
AKT pS473 Antibody, anti-human/mouse, PE-Vio® 770, REAfinity™
目录 :
130-105-343
规格 :
100试验在1毫升
价格 :
315, 00美元
克隆性 :
单克隆
宿主 :
人类
共轭标签 :
PE
克隆名称 :
REA359
反应物种 :
人类, 小鼠
应用 :
流式细胞仪
更多信息或购买 :
文章摘录数: 3
参考文献
Arranz A, Doxaki C, Vergadi E, Martinez de la Torre Y, Vaporidi K, Lagoudaki E, et al. Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc Natl Acad Sci U S A. 2012;109:9517-22 pubmed 出版商
Calamito M, Juntilla M, Thomas M, Northrup D, Rathmell J, Birnbaum M, et al. Akt1 and Akt2 promote peripheral B-cell maturation and survival. Blood. 2010;115:4043-50 pubmed 出版商
Santi S, Lee H. The Akt isoforms are present at distinct subcellular locations. Am J Physiol Cell Physiol. 2010;298:C580-91 pubmed 出版商
产品信息
目录代码 :
130-105-343
产品名称 :
AKT pS473 Antibody, anti-human/mouse, PE-Vio® 770, REAfinity™
产品类型 :
抗体
宿主物种 :
细胞系
克隆性 :
单克隆
共轭 :
PE-Vio 770
抗原修饰 :
AKT pS473
克隆名称 :
REA359
抗体亚型 :
重组人类IgG1
照明链 :
kappa light chain
规格 :
100试验在1毫升
美国标价 :
315, 00美元
产品描述 :
Clone REA359 recognizes the human and mouse Akt antigen phosphorylated at serine 473 (pS473). Akt is a family of serine/threonine kinases which is also known as protein kinase B (PKB) or related to the A and C kinases (RAC-PK). Akt intricately regulates many cellular functions such as cell growth and proliferation, cell survival, apoptosis, energy metabolism, and resistance to anticancer therapeutics. It consists of three isoforms, Akt1, Akt2, and Akt3 (or PKBα, β, and γ). Although these three isoforms are encoded by separate genes, they share a common NH2-terminal pleckstrin homology (PH) domain, a catalytic domain in the middle, and a COOH terminus. The identity of the overall amino acid sequence of the three isoforms is very high (about 80%), however, the COOH terminus and the PH-linker region are more diverse. All three isoforms contain similar phosphorylation/activation sites: threonine 308 (Akt1), 309 (Akt2), and 305 (Akt3) and serine 473 (Akt1), 474 (Akt2), and 472 (Akt3). Phosphorylated or activated Akt regulates many of its cellular functions through the phosphorylation of a series of downstream players. Additional information: Clone REA359 displays negligible binding to Fc receptors.
别名 :
Akt1, CWS6, PKB, PKB-甲, RAC, RAC-甲, PKBγ, PKBβ, STK-2
特异性 :
人类, 小鼠
浓度 :
1:11
用途 :
For research use only
应用摘要 :
流式细胞仪
储存 :
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
更多信息或购买 :
公司信息
美天旎
Friedrich-Ebert-Strae 68
51429 Bergisch Gladbach
macs@miltenyibiotec.com
https://www.miltenyibiotec.com
1 800 FOR MACS
公司总部: 德国