抗体

兔snail 1锌指蛋白(Ab-246)抗体

MBS000031

0.05毫升

270美元

多克隆

兔

未共轭

人类, 小鼠

免疫印迹, 酶联免疫吸附测定, 酶免疫法

抗体

兔snail 1锌指蛋白(Ab-246)抗体

snail 1锌指蛋白(Ab-246)

zinc finger protein SNAI1; Zinc finger protein SNAI1; zinc finger protein SNAI1; protein sna; snail 1 homolog; snail homolog 1; protein snail homolog 1; snail 1 zinc finger protein; snail 1, zinc finger protein; snail family zinc finger 1; Protein snail homolog 1

snail 1锌指蛋白

SNAI1; SNAI1; SNA; SNAH; SNAIL; SLUGH2; SNAIL1; dJ710H13.1; SNAH; Protein sna

SNAI1_HUMAN

兔

人类, 小鼠

264

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

1毫克/毫升

酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

18765741

NP_005976.2

NM_005985.3

O95863

29,083 Da

Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Neural Crest Differentiation Pathway (672460); Signaling Events Mediated By Hepatocyte Growth Factor Receptor (c-Met) Pathway (137930); Validated Targets Of C-MYC Transcriptional Activation Pathway (169351)

The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008]

Snail1: a protein of the C2H2-type zinc-finger family that regulates transcription. Involved in embryonic mesoderm formation. Plays a role in the epithelial to mesenchymal transition (EMT). EMT is characterized by decreased levels of the epithelial markers E-cadherin and alpha- and beta-catenin, and increased cellular migration and expression of the mesenchymal markers fibronectin, vimentin, N-cadherin and smooth muscle alpha-actin.E Snail binds to 3 E-boxes of the E-cadherin gene promoter and represses its transcription. NF-kappaB binds and regulates the snail promoter and is critical for EMT, and inhibition of NF-kappaB activity lowered snail levels and morphologically reversed the EMT. Protein type: Transcription factor; C2H2-type zinc finger protein. Chromosomal Location of Human Ortholog: 20q13.2. Cellular Component: cytoplasm; nucleus. Molecular Function: protein binding; metal ion binding; kinase binding. Biological Process: osteoblast differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; cell migration; hair follicle morphogenesis; mesoderm formation; positive regulation of transcription, DNA-dependent; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; palate development; positive regulation of cell migration

0.05毫升

270美元

0.1毫升

445