产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
兔肌动蛋白甲抗体
目录 :
MBS001201
规格 :
0.05毫升
价格 :
270美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS001201
产品类型 :
抗体
产品全称 :
兔肌动蛋白甲抗体
产品简称 :
肌动蛋白甲
产品名称同义词 :
肌动蛋白a
其他名称 :
肌动蛋白, 甲骨骼肌;肌动蛋白, 甲骨骼肌;肌动蛋白, 甲骨骼肌;杆状体肌病类型3;肌动蛋白, 甲1, 骨骼肌;阿尔法肌动蛋白
其他基因名称 :
ACTA1;ACTA1;ACTA;ASMA;CFTD;MPFD;NEM1;NEM2;NEM3;CFTD1;CFTDM;ACTA
UniProt数据库进入名 :
ACTS_HUMAN
宿主 :
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
377
形式 :
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
浓度 :
1毫克/毫升
检测过的应用 :
酶联免疫吸附测定(EIA), 免疫组化(免疫组化), 免疫印迹(免疫印迹)
NCBI GI登录号 :
4501881
NCBI登录号 :
NP_001091.1
NCBI基因登录号 :
NM_001100.3
UniProt数据库登录号 :
P68133
NCBI分子量 :
42,051 Da
NCBI信号通路 :
Caspase Cascade In Apoptosis Pathway 137974!!Hypothetical Network For Drug Addiction Pathway 198776!!Myometrial Relaxation And Contraction Pathways 198759!!RhoA Signaling Pathway 169356!!Signaling Events Mediated By Focal Adhesion Kinase Pathway 169348!!Striated Muscle Contraction Pathway 198903
NCBI总结 :
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Subunit structure: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X . By similarity. Interacts with TTID. Interacts (via its C-terminus) with USP25; the interaction occurs for all USP25 isoforms but is strongest for isoform USP25m in muscle differentiating cells. Ref.8 Ref.9. Subcellular location: Cytoplasm cytoskeleton. Post-translational modification: Oxidation of Met-46 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced . By similarity. Involvement in disease: Nemaline myopathy 3 (NEM3) [MIM:161800]: A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. Some patients present areas devoid of oxidative activity containg (cores) within myofibers. Core lesions are unstructured and poorly circumscribed.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.3 Ref.11 Ref.13 Ref.14 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.22Myopathy, actin, congenital, with excess of thin myofilaments (MPCETM) [MIM:161800]: A congenital muscular disorder characterized at histological level by areas of sarcoplasm devoid of normal myofibrils and mitochondria, and replaced with dense masses of thin filaments. Central cores, rods, ragged red fibers, and necrosis are absent.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.3Congenital myopathy with fiber-type disproportion (CFTD) [MIM:255310]: Genetically heterogeneous disorder in which there is relative hypotrophy of type 1 muscle fibers compared to type 2 fibers on skeletal muscle biopsy. However, these findings are not specific and can be found in many different myopathic and neuropathic conditions.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.15 Ref.21. Miscellaneous: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Sequence similarities: Belongs to the actin family.
规格 :
0.05毫升
价格 :
270美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。