产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
兔BAD(磷酸化Ser91/128)抗体
目录 :
MBS004216
规格 :
0.05毫升
价格 :
270美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS004216
产品类型 :
抗体
产品全称 :
兔BAD(磷酸化Ser91/128)抗体
产品简称 :
BAD(磷酸化Ser91/128)
其他名称 :
bcl2 antagonist of cell death; Bcl2 antagonist of cell death; bcl2 antagonist of cell death; bcl2-L-8; BCL2-binding protein; bcl-2-like protein 8; BCL2-binding component 6; bcl-2-binding component 6; BCL-X/BCL-2 binding protein; BCL2-antagonist of cell death protein; bcl-XL/Bcl-2-associated death promoter; BCL2-associated agonist of cell death; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-XL/Bcl-2-associated death promoter
产品基因名称 :
BAD
其他基因名称 :
BAD;BAD;BBC2;BCL2L8;BBC6;BCL2L8;BAD;Bcl2-L-8
UniProt数据库进入名 :
BAD_HUMAN
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
168
特异性 :
BAD (Phospho-Ser91/128) antibody detects endogenous levels of BAD only when phosphorylated at serine 91/ serine 128.
纯度 :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation
形式 :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
浓度 :
1毫克/毫升
储存稳定性 :
Store at -20 degree C
检测过的应用 :
酶联免疫吸附测定(EIA), 免疫组化(免疫组化), 免疫印迹(免疫印迹)
应用笔记 :
WB: 1:500~1:3000。 IHC: 1:50~1:100。 ELISA: 1:10000
其它信息1 :
All Sites: Human: Ser91; Mouse: Ser128; Rat: Ser129. Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human BAD around the phosphorylation site of serine 91/ serine 128 (E-L-SP-P-F).
NCBI GI登录号 :
10835069
NCBI登录号 :
NP_004313.1
NCBI基因登录号 :
NM_004322.3
UniProt数据库登录号 :
Q92934
NCBI分子量 :
18,392 Da
NCBI信号通路 :
AKT Phosphorylates Targets In The Cytosol Pathway (106475); Activation Of BAD And Translocation To Mitochondria Pathway (105659); Activation Of BH3-only Proteins Pathway (105658); Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adaptive Immune System Pathway (366160); Alpha-synuclein Signaling Pathway (137913); Alpha6-Beta4 Integrin Signaling Pathway (198807); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509)
NCBI总结 :
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
BAD: a proapoptotic member of the Bcl-2 family. Displaces Bax from binding to Bcl-2 and Bcl-xL, resulting in cell death. Survival factors such as IL-3 can inhibit the apoptotic activity of Bad inducing the phosphorylation of Bad by Akt and p90RSK. 14-3-3 proteins bind phosphorylated Bad, inhibiting its binding to Bcl-2 and Bcl-xL. Phosphorylation by mitochondria-anchored PKA in the BH3 domain can block the dimerization of Bad and Bcl-xL. Protein type: Apoptosis. Chromosomal Location of Human Ortholog: 11q13.1. Cellular Component: mitochondrial outer membrane; mitochondrion; cytosol. Molecular Function: protein kinase B binding; protein binding; protein heterodimerization activity; phospholipid binding; caspase activator activity; lipid binding; protein kinase binding; protein phosphatase 2B binding. Biological Process: response to oleate; nerve growth factor receptor signaling pathway; positive regulation of proteolysis; apoptosis; positive regulation of apoptosis; response to glucocorticoid stimulus; positive regulation of caspase activity; glucose homeostasis; cellular process regulating host cell cycle in response to virus; positive regulation of apoptosis by virus; response to estradiol stimulus; response to glucose stimulus; pore complex biogenesis; positive regulation of autophagy; positive regulation of glucokinase activity; response to drug; caspase activation; epidermal growth factor receptor signaling pathway; release of cytochrome c from mitochondria; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; cytokine and chemokine mediated signaling pathway; suppression by virus of host apoptosis; positive regulation of insulin secretion; ADP metabolic process; response to testosterone stimulus; response to amino acid stimulus; ATP metabolic process; glucose catabolic process; response to ethanol; induction of apoptosis via death domain receptors; positive regulation of T cell differentiation; response to hydrogen peroxide; DNA damage response, signal transduction resulting in induction of apoptosis; innate immune response; positive regulation of B cell differentiation; regulation of mitochondrial membrane permeability; response to progesterone stimulus; response to calcium ion; positive regulation of epithelial cell proliferation
尺寸1 :
0.05毫升
价格1 :
270美元
尺寸2 :
0.1毫升
价格2 :
445
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。